Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma von Singhania, Akul, Rupani, Hitasha, Jayasekera, Nivenka, Lumb, Simon, Hales, Paul, Gozzard, Neil, Davies, Donna E, Woelk, Christopher H, Howarth, Peter H

Volltext

Efficacy of an Inhaled IL-13 Antibody Fragment in a Model of Chronic Asthma von Lightwood, Daniel, Tservistas, Markus, Zehentleitner, Monique, Sarkar, Kaushik, Turner, Alison, Bracher, Marguerite, Smith, Bryan, Lamour, Sabrina, Bourne, Tim, Shaw, Stevan, Gozzard, Neil, Palframan, Roger T

Volltext

TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation von Hardyman, Michelle A., PhD, Wilkinson, Emily, BSc, Martin, Emma, BMedSci, Jayasekera, Nivenka P., MD, Blume, Cornelia, PhD, Swindle, Emily J., PhD, Gozzard, Neil, PhD, Holgate, Stephen T., MD, DSc, Howarth, Peter H., MD, DM, Davies, Donna E., PhD, Collins, Jane E., PhD

Volltext

Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity von Hayes, Alan J, Rane, Sanket, Scales, Hannah E, Meehan, Gavin R, Benson, Robert A, Maroof, Asher, Schroeder, Juliane, Tomura, Michio, Gozzard, Neil, Yates, Andrew J, Garside, Paul, Brewer, James M

Volltext

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum -omics von Lefaudeux, Diane, MSc, De Meulder, Bertrand, PhD, Loza, Matthew J., PhD, Peffer, Nancy, BS, Rowe, Anthony, PhD, Baribaud, Frédéric, PhD, Bansal, Aruna T., PhD, Lutter, Rene, PhD, Sousa, Ana R., PhD, Corfield, Julie, MSc, Pandis, Ioannis, PhD, Bakke, Per S., MD, Caruso, Massimo, MD, Chanez, Pascal, MD, Dahlén, Sven-Erik, MD, Fleming, Louise J., MD, Fowler, Stephen J., MD, Horvath, Ildiko, MD, Krug, Norbert, MD, Montuschi, Paolo, MD, Sanak, Marek, MD, Sandstrom, Thomas, MD, Shaw, Dominic E., MD, Singer, Florian, MD, Sterk, Peter J., MD, PhD, Roberts, Graham, MD, Adcock, Ian M., PhD, Djukanovic, Ratko, MD, Auffray, Charles, PhD, Chung, Kian. F., MD

Volltext

IL-17–high asthma with features of a psoriasis immunophenotype von Schofield, James P.R., Ward, Jonathan, Montuschi, Paolo, Auffray, Charles, Adcock, Ian M., Howarth, Peter, Vaarala, Outi, Bates, S., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Bucchioni, E., Burg, D., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., Fichtner, K., Fitch, N., Fowler, S.J., Frey, U., Gahlemann, M., Hashimoto, S., Hedlin, G., Knox, A.J., Lutter, R., Middelveld, R.J.M., Mores, N., Myles, D., Pavlidis, S., Rao, M. Puig N., Rowe, A., Sandström, T., Sigmund, R., Singer, F., Sousa, A.R., Sun, K., Thornton, B., van Aalderen, W.M., Vestbo, J., Wilson, S.J., Badorrek, P., Barber, Clair, Batuwitage, Manohara Kanangana, Berton, A., Bochenek, Grazyna, Dahlén, B., De Alba, Jorge, Dekker, Tamara, Dennison, P., Dodson, Paul, Edwards, Jessica, Emma, Rosalia, Flood, Breda, Guillmant-Farry, E., Hewitt, Lorraine, Hu, X., Johnson, K., Klüglich, M., Kots, Maxim, Kuo, Scott, Lambrecht, Bart, Lantz, A.-S., Latzin, P., Lemonnier, N., Lone-Latif, Saeeda, Manta, Alexander, Martin, Jane, Metcalf, Leanne, Mikus, Maria, Monk, Philip, Nething, K., Nicholas, Ben, Niven, R., Nordlund, B., Nsubuga, S., Palkonen, Susanna, Pellet, J., Pennazza, Giorgio, Petrén, Anne, Pink, Sandy, Rahman-Amin, Malayka, Reynolds, Leanne, Robberechts, Martine, Russell, Kirsty, Rutgers, Michael, Santini, G., Saqi, M., Scott, S., Smith, Katherine M., Stephan, S., Strandberg, K., Szentkereszty, M., Tariq, K., Thorsen, Jonathan, van Drunen, C.M., Wetzel, Kristiane, Wiegman, Coen, Yeyasingham, Elizabeth, Zetterquist, W.

Volltext

Stratification of asthma phenotypes by airway proteomic signatures von Burg, Dominic, Nicholas, Ben, Strazzeri, Fabio, Staykova, Doroteya, Bansal, Aruna T., Xian, Yang, Corfield, Julie, Wilson, Susan, Ward, Jonathan, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sandström, Thomas, Sun, Kai, Riley, John, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Sterk, Peter J., Djukanović, Ratko, Ahmed, H., Badorrek, P., Ballereau, S., Baribaud, F., Behndig, A.F., Berglind, A., Berton, A., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bush, A., Casaulta, C., Chaiboonchoe, A., Davison, T., De Meulder, B., Delin, I., El Hadjam, L., Erzen, D., Faulenbach, C., Fitch, N., Formaggio, E., Gahlemann, M., Garissi, D., Garret, T., Gent, J., Guillmant-Farry, E., Henriksson, E., James, A., Johnson, K., Jullian, N., Kerry, G., Klüglich, M., Knowles, R., Konradsen, J.R., Kretsos, K., Lantz, A.-S., Larminie, C., Latzin, P., Lefaudeux, D., Lemonnier, N., Lowe, L.A., Lutter, R., Mazein, A., McEvoy, L., Mores, N., Murray, C.S., Nething, K., Nordlund, B., Nsubuga, S., Pellet, J., Pison, C., Praticò, G., Valls, M. Puig, Rossios, C., Santini, G., Saqi, M., Sehgal, N., Söderman, P., Sogbesan, A., Spycher, F., Stephan, S., Stokholm, J., Sunther, M., Szentkereszty, M., Tamasi, L., Valente, S., van Aalderen, W.M., van Drunen, C.M., Van Eyll, J., Vyas, A., Yu, W., Zwinderman, A.H.

Volltext

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study von Loza, Matthew J, Djukanovic, Ratko, Chung, Kian Fan, Horowitz, Daniel, Ma, Keying, Branigan, Patrick, Barnathan, Elliot S, Susulic, Vedrana S, Silkoff, Philip E, Sterk, Peter J, Baribaud, Frédéric

Volltext

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux von Perotin, Jeanne-Marie, Schofield, James P R, Wilson, Susan J, Ward, Jonathan, Brandsma, Joost, Strazzeri, Fabio, Bansal, Aruna, Yang, Xian, Rowe, Anthony, Corfield, Julie, Lutter, Rene, Shaw, Dominick E, Bakke, Per S, Caruso, Massimo, Dahlén, Barbro, Fowler, Stephen J, Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Riley, John H, Sousa, Ana R, Dahlen, Sven-Erik, Adcock, Ian M, Chung, Kian Fan, Sterk, Peter J, Skipp, Paul J, Collins, Jane E, Davies, Donna E, Djukanović, Ratko

Volltext

The RA-MAP Consortium: a working model for academia–industry collaboration von Cope, Andrew P., Barnes, Michael R., Belson, Alexandra, Binks, Michael, Brockbank, Sarah, Bonachela-Capdevila, Francisco, Carini, Claudio, Fisher, Benjamin A., Goodyear, Carl S., Emery, Paul, Ehrenstein, Michael R., Gozzard, Neil, Harris, Ray, Hollis, Sally, Keidel, Sarah, Levesque, Marc, Lindholm, Catharina, McDermott, Michael F., McInnes, Iain B., Mela, Christopher M., Parker, Gerry, Read, Simon, Pedersen, Ayako Wakatsuki, Ponchel, Frederique, Porter, Duncan, Rao, Ravi, Rowe, Anthony, Schulz-Knappe, Peter, Sleeman, Matthew A., Symmons, Deborah, Taylor, Peter C., Tom, Brian, Tsuji, Wayne, Verbeeck, Denny, Isaacs, John D.

Volltext

Certolizumab Pegol and Adalimumab Accumulation in the Inflammed Paws of Mice with Collagen-induced Arthritis Compared to Noninflammed Tissue In Vivo Biofluorescence Imaging of Alex... von Palframan, Roger, Senior Group Leader, UCB Celltech, Pharmacology, Slough, UK, Vugler, Alex, Research Scientist, UCB Celltech, Pharmacology, Slough, UK, Moore, Adrian, Senior Group Leader, UCB Celltech, Pharmacology, Slough, UK, Baker, Mark, Research Scientist, UCB Celltech, Clinical Pharmacology and Experimental Medicine, Slough, UK, Lightwood, Daniel, Group Leader, UCB Celltech, Antibody Biology, Slough, UK, Nesbitt, Andrew, Senior Group Leader, UCB Celltech, Inflammation Discovery, Slough, UK, Foulkes, Roly, Director, UCB Celltech, Non-clinical Development/Inflammation Therapeutic Area, Slough, UK, Gozzard, Neil, Director, UCB Celltech, Pharmacology, Slough, UK

Volltext

The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation von Lightwood, Daniel, O'Dowd, Victoria, Carrington, Bruce, Veverka, Vaclav, Carr, Mark D., Tservistas, Markus, Henry, Alistair J., Smith, Bryan, Tyson, Kerry, Lamour, Sabrina, Sarkar, Kaushik, Turner, Alison, Lawson, Alastair D., Bourne, Tim, Gozzard, Neil, Palframan, Roger

Volltext

Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration von Cope, Andrew P., Barnes, Michael R., Belson, Alexandra, Binks, Michael, Brockbank, Sarah, Bonachela-Capdevila, Francisco, Carini, Claudio, Fisher, Benjamin A., Goodyear, Carl S., Emery, Paul, Ehrenstein, Michael R., Gozzard, Neil, Harris, Ray, Hollis, Sally, Keidel, Sarah, Levesque, Marc, Lindholm, Catharina, McDermott, Michael F., McInnes, Iain B., Mela, Christopher M., Parker, Gerry, Read, Simon, Pedersen, Ayako Wakatsuki, Ponchel, Frederique, Porter, Duncan, Rao, Ravi, Rowe, Anthony, Schulze-Knappe, Peter, Sleeman, Matthew A., Symmons, Deborah, Taylor, Peter C., Tom, Brian, Tsuji, Wayne, Verbeeck, Denny, Isaacs, John D.

Volltext

Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration von Cope, Andrew P, Barnes, Michael R, Belson, Alexandra, Binks, Michael, Brockbank, Sarah, Bonachela-Capdevila, Francisco, Carini, Claudio, Fisher, Benjamin A, Goodyear, Carl S, Emery, Paul, Ehrenstein, Michael R, Gozzard, Neil, Harris, Ray, Hollis, Sally, Keidel, Sarah, Levesque, Marc, Lindholm, Catharina, McDermott, Michael F, McInnes, Iain B, Mela, Christopher M, Parker, Gerry, Read, Simon, Pedersen, Ayako Wakatsuki, Ponchel, Frederique, Porter, Duncan, Rao, Ravi, Rowe, Anthony, Schulze-Knappe, Peter, Sleeman, Matthew A, Symmons, Deborah, Taylor, Peter C, Tom, Brian, Tsuji, Wayne, Verbeeck, Denny, Isaacs, John D

Volltext

TNF-[alpha]-mediated bronchial barrier disruption and regulation by src-family kinase activation von Hardyman, Michelle A, Wilkinson, Emily, Martin, Emma, Jayasekera, Nivenka P, Blume, Cornelia, Swindle, Emily J, Gozzard, Neil, Holgate, Stephen T, Howarth, Peter H, Davies, Donna E, Collins, Jane E

Volltext

Poly I:C causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund's complete adjuvant von De Alba, Jorge, Otal, Raquel, Calama, Elena, Gil, Félix, Gozzard, Neil, Miralpeix, Montserrat

Volltext

Immunological characterisation of an acute murine model of lung inflammation and airway hyperreactivity von Dixon, Kate L, Ching, Yee-Man, Coote, Julie, Gozzard, Neil

Volltext

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma von Babu, Suresh K, Puddicombe, Sarah M, Arshad, Hasan H, Wilson, Susan J, Ward, John, Gozzard, Neil, Higgs, Gerry, Holgate, Stephen T, Davies, Donna E

Volltext

Corrigendum to “The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation” [J. Mol. Biol. 425 (2013... von Lightwood, Daniel, O'Dowd, Victoria, Carrington, Bruce, Veverka, Vaclav, Carr, Mark D., Tservistas, Markus, Henry, Alistair J., Smith, Bryan, Tyson, Kerry, Lamour, Sabrina, Bracher, Marguerite, Sarkar, Kaushik, Turner, Alison, Lawson, Alastair D., Bourne, Tim, Gozzard, Neil, Palframan, Roger

Volltext

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Volltext