The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival von Ohguchi, Hiroto, Hideshima, Teru, Bhasin, Manoj K., Gorgun, Gullu T., Santo, Loredana, Cea, Michele, Samur, Mehmet K., Mimura, Naoya, Suzuki, Rikio, Tai, Yu-Tzu, Carrasco, Ruben D., Raje, Noopur, Richardson, Paul G., Munshi, Nikhil C., Harigae, Hideo, Sanda, Takaomi, Sakai, Juro, Anderson, Kenneth C.

Volltext

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug von Ramsay, Alan G, Johnson, Amy J, Lee, Abigail M, Gorgün, Güllü, Le Dieu, Rifca, Blum, William, Byrd, John C, Gribben, John G

Volltext

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition von MIMURA, Naoya, HIDESHIMA, Teru, CIRSTEA, Diana, GORGUN, Gullu, MINAMI, Jiro, TAI, Yu-Tzu, RICHARDSON, Paul G, UTSUGI, Teruhiro, IWAMA, Atsushi, ANDERSON, Kenneth C, SHIMOMURA, Toshiyasu, SUZUKI, Rikio, OHGUCHI, Hiroto, RIZQ, Ola, KIKUCHI, Shohei, YOSHIDA, Yasuhiro, COTTINI, Francesca, JAKUBIKOVA, Jana

Volltext

Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma von Cirstea, Diana, Hideshima, Teru, Rodig, Scott, Santo, Loredana, Pozzi, Samantha, Vallet, Sonia, Ikeda, Hiroshi, Perrone, Giulia, Gorgun, Gullu, Patel, Kishan, Desai, Neil, Sportelli, Peter, Kapoor, Shweta, Vali, Shireen, Mukherjee, Siddhartha, Munshi, Nikhil C, Anderson, Kenneth C, Raje, Noopur

Volltext

Eμ-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction von Gorgun, Gullu, Ramsay, Alan G, Holderried, Tobias A.W, Zahrieh, David, Le Dieu, Rifca, Liu, Fenglong, Quackenbush, John, Croce, Carlo M, Gribben, John G

Volltext

Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells von Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Mimura, Naoya, Minami, Jiro, Ohguchi, Hiroto, Yoshida, Yasuhiro, Sagawa, Morihiko, Gorgun, Gullu, Cirstea, Diana, Cottini, Francesca, Jakubikova, Jana, Tai, Yu-Tzu, Chauhan, Dharminder, Richardson, Paul G, Munshi, Nikhil, Ando, Kiyoshi, Utsugi, Teruhiro, Hideshima, Teru, Anderson, Kenneth C

Volltext

Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma von Cirstea, Diana, Santo, Loredana, Hideshima, Teru, Eda, Homare, Mishima, Yuko, Nemani, Neeharika, Mahindra, Anuj, Yee, Andrew, Gorgun, Gullu, Hu, Yiguo, Ohguchi, Hiroto, Suzuki, Rikio, Cottini, Francesca, Guichard, Sylvie M, Anderson, Kenneth C, Raje, Noopur

Volltext

A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells von Hideshima, Teru, Mitsiades, Constantine, Ikeda, Hiroshi, Chauhan, Dharminder, Raje, Noopur, Gorgun, Gullu, Hideshima, Hiromasa, Munshi, Nikhil C., Richardson, Paul G., Carrasco, Daniel R., Anderson, Kenneth C.

Volltext

Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease von Gorgun, Gullu, Miller, Kenneth B., Foss, Francine M.

Volltext

P1098: A PHASE II, OPEN‐LABEL, MULTICENTER STUDY OF CAPIVASERTIB, A POTENT, ORAL PAN‐AKT INHIBITOR, IN PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN LYMPHOMA (CAPITAL)... von Hodson, Daniel, Shouse, Geoffrey, Shin, Ho‐Jin, Salar Silvestre, Antonio, Bobillo Varela, Sabela, Ribrag, Vincent, Macpherson, Nicol, Cordoba, Raul, Seok Kim, Jin, Radford, John, Guidez, Stephanie, Herrera, Alex F., Morschhauser, Franck, Johnson, Dachelle, Izuzquiza, Macarena, Sambamurthy, Nisha, Forcina, Alessandra, Gorgun, Gullu, Chen, Robert, Younes, Anas, Wang, Michael, Seog Kim, Wong

Volltext

A community‐based lung cancer rapid tissue donation protocol provides high‐quality drug‐resistant specimens for proteogenomic analyses von Boyle, Theresa A., Quinn, Gwendolyn P., Schabath, Matthew B., Muñoz‐Antonia, Teresita, Saller, James J., Duarte, Luisa F., Hair, Laura S., Teer, Jamie K., Chiang, Derek Y., Leary, Rebecca, Wong, Connie C., Savchenko, Alexander, Singh, Angad P., Charette, LaSalette, Mendell, Kate, Gorgun, Gullu, Antonia, Scott J., Chiappori, Alberto A., Creelan, Benjamin C., Gray, Jhanelle E., Haura, Eric B.

Volltext

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma von Minami, J, Suzuki, R, Mazitschek, R, Gorgun, G, Ghosh, B, Cirstea, D, Hu, Y, Mimura, N, Ohguchi, H, Cottini, F, Jakubikova, J, Munshi, N C, Haggarty, S J, Richardson, P G, Hideshima, T, Anderson, K C

Volltext

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma von Mimura, Naoya, Fulciniti, Mariateresa, Gorgun, Gullu, Tai, Yu-Tzu, Cirstea, Diana, Santo, Loredana, Hu, Yiguo, Fabre, Claire, Minami, Jiro, Ohguchi, Hiroto, Kiziltepe, Tanyel, Ikeda, Hiroshi, Kawano, Yutaka, French, Maureen, Blumenthal, Martina, Tam, Victor, Kertesz, Nathalie L., Malyankar, Uriel M., Hokenson, Mark, Pham, Tuan, Zeng, Qingping, Patterson, John B., Richardson, Paul G., Munshi, Nikhil C., Anderson, Kenneth C.

Volltext

First Disclosure of AZD9829, a TOP1i-ADC Targeting CD123: Promising Preclinical Activity in AML Models with Minimal Effect on Healthy Progenitors von Dutta, Dipannita, Pan, Pan, Fleming, Ryan, Andrade-Campos, Marcio, Belova, Elena, Wheeler, Jennifer, Cheung, Patricia, Santacroce, Paul, Daniels, Casey, Sabol, Darrin, Jakubison, Brad, Recolin, Benedicte, Dippel, Andrew, Wey, Margaret, Shaffer, Arthur, Rosfjord, Edward, Hurt, Elaine, Gorgun, Gullu, Younes, Anas, Sapra, Puja

Volltext

PI3K/p110δ is a novel therapeutic target in multiple myeloma von Ikeda, Hiroshi, Hideshima, Teru, Fulciniti, Mariateresa, Perrone, Giulia, Miura, Naoya, Yasui, Hiroshi, Okawa, Yutaka, Kiziltepe, Tanyel, Santo, Loredana, Vallet, Sonia, Cristea, Diana, Calabrese, Elisabetta, Gorgun, Gullu, Raje, Noopur S., Richardson, Paul, Munshi, Nikhil C., Lannutti, Brian J., Puri, Kamal D., Giese, Neill A., Anderson, Kenneth C.

Volltext

Targeting the bone marrow microenvironment in multiple myeloma von Kawano, Yawara, Moschetta, Michele, Manier, Salomon, Glavey, Siobhan, Görgün, Güllü T., Roccaro, Aldo M., Anderson, Kenneth C., Ghobrial, Irene M.

Volltext

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition von Santo, L, Vallet, S, Hideshima, T, Cirstea, D, Ikeda, H, Pozzi, S, Patel, K, Okawa, Y, Gorgun, G, Perrone, G, Calabrese, E, Yule, M, Squires, M, Ladetto, M, Boccadoro, M, Richardson, P G, Munshi, N C, Anderson, K C, Raje, N

Volltext

Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs von Cirstea, D, Hideshima, T, Santo, L, Eda, H, Mishima, Y, Nemani, N, Hu, Y, Mimura, N, Cottini, F, Gorgun, G, Ohguchi, H, Suzuki, R, Loferer, H, Munshi, N C, Anderson, K C, Raje, N

Volltext

Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans von Görgün, Güllü Topal, Whitehill, Gregory, Anderson, Jennifer L., Hideshima, Teru, Maguire, Craig, Laubach, Jacob, Raje, Noopur, Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C.

Volltext

Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma von Görgün, Güllü, Samur, Mehmet K, Cowens, Kristen B, Paula, Steven, Bianchi, Giada, Anderson, Julie E, White, Randie E, Singh, Ahaana, Ohguchi, Hiroto, Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Hideshima, Teru, Tai, Yu-Tzu, Laubach, Jacob P, Raje, Noopur, Magrangeas, Florence, Minvielle, Stephane, Avet-Loiseau, Herve, Munshi, Nikhil C, Dorfman, David M, Richardson, Paul G, Anderson, Kenneth C

Volltext