Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target von Henley, Zoë A, Amour, Augustin, Barton, Nick, Bantscheff, Marcus, Bergamini, Giovanna, Bertrand, Sophie M, Convery, Máire, Down, Kenneth, Dümpelfeld, Birgit, Edwards, Chris D, Grandi, Paola, Gore, Paul M, Keeling, Steve, Livia, Stefano, Mallett, David, Maxwell, Aoife, Price, Mark, Rau, Christina, Reinhard, Friedrich B. M, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Thomas, Daniel A, Hessel, Edith M, Hamblin, J. Nicole

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The discovery of quinoline based single-ligand human H 1 and H 3 receptor antagonists von Procopiou, Panayiotis A, Ancliff, Rachael A, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Keeling, Steven P, Looker, Brian E, Parr, Nigel A, Rowedder, James E, Slack, Robert J

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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H 1 receptor antagonists for use in allergic rhinitis von Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Watts, Clarissa J

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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis von Procopiou, Panayiotis A., Ford, Alison J., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Vile, Sadie, Clark, Kenneth L., Saunders, Ken A., Slack, Robert J., Watts, Clarissa J.

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The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists von Procopiou, Panayiotis A., Ancliff, Rachael A., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Keeling, Steven P., Looker, Brian E., Parr, Nigel A., Rowedder, James E., Slack, Robert J.

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Design of Phthalazinone Amide Histamine H 1 Receptor Antagonists for Use in Rhinitis von Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

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Synthesis and pharmacological investigation of azaphthalazinone human histamine H1 receptor antagonists von Procopiou, Panayiotis A., Browning, Christopher, Gore, Paul M., Lynn, Sean M., Richards, Stephen A., Slack, Robert J., Sollis, Steven L.

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The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis von Procopiou, Panayiotis A, Browning, Christopher, Buckley, Jennifer M, Clark, Kenneth L, Fechner, Lise, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Kranz, Michael, Looker, Brian E, Morriss, Karen M. L, Parton, Daniel L, Russell, Linda J, Slack, Robert J, Sollis, Steven L, Vile, Sadie, Watts, Clarissa J

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Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis von Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

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Divergent approach to imino sugar C-glycosides using imino glycals: application to the stereocontrolled synthesis of (+)-deoxoprosophylline von Dransfield, Paul J, Gore, Paul M, Shipman, Michael, Slawin, Alexandra M Z

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Preparation and reactivity of imino glycals: stereocontrolled, divergent approach to imino sugars von Dransfield, Paul J, Gore, Paul M, Prokes, Ivan, Shipman, Michael, Slawin, Alexandra M Z

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The Discovery of Phthalazinone-Based Human H 1 and H 3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis von Procopiou, Panayiotis A., Browning, Christopher, Buckley, Jennifer M., Clark, Kenneth L., Fechner, Lise, Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Kranz, Michael, Looker, Brian E., Morriss, Karen M. L., Parton, Daniel L., Russell, Linda J., Slack, Robert J., Sollis, Steven L., Vile, Sadie, Watts, Clarissa J.

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New Spiropiperidines as Potent and Selective Non-Peptide Tachykinin NK2 Receptor Antagonists von Smith, Paul W, Cooper, Anthony W. J, Bell, Richard, Beresford, Isabel J. M, Gore, Paul M, McElroy, Andrew B, Pritchard, John M, Saez, Victoria, Taylor, Neil R

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Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists von Procopiou, Panayiotis A, Browning, Christopher, Gore, Paul M, Lynn, Sean M, Richards, Stephen A, Slack, Robert J, Sollis, Steven L

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Chemistry of Imino Glycals: Preparation and Application to the Synthesis of (+)-Fagomine von Désiré, Jérôme, Dransfield, Paul J., Gore, Paul M., Shipman, Michael

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Intermediates for the synthesis of linear chains of 1,2:4,5-fused cyclohexa-1,4-diene rings and beltenes by repeated Diels–Alder reactions von Alder, Roger W., Allen, Paul R., Edwards, Lee S., Fray, Gordon I., Fuller, Katy E., Gore, Paul M., Hext, Nicholas M., Perry, Martin H., Thomas, Alex R., Turner, Kevin S.

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Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate character von Bamford, Mark J., Bird, Michael, Gore, Paul M., Holmes, Duncan S., Priest, Richard, Prodger, Jeremy C., Saez, Victoria

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Synthesis of a novel analogue of sialyl Lewis X von Prodger, Jeremy C., Bamford, Mark J., Gore, Paul M., Holmes, Duncan S., Saez, Victoria, Ward, Peter

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Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-Acetylglucosamine sugar with simple C2-symmetric 1,2-diols von Prodger, Jeremy C., Bamford, Mark J., Bird, Michael I., Gore, Paul M., Holmes, Duncan S., Priest, Richard, Saez, Victoria

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GR159897 and related analogues as highly potent, orally active non-peptide neurokinin NK2 receptor antagonists von Cooper, Anthony W.J., Adams, Hilary S., Bell, Richard, Gore, Paul M., McElroy, Andrew B., Pritchard, John M., Smith, Paul W., Ward, Peter

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