Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes von Goodwin, Nicole C, Ding, Zhi-Ming, Harrison, Bryce A, Strobel, Eric D, Harris, Angela L, Smith, Melinda, Thompson, Andrea Y, Xiong, Wendy, Mseeh, Faika, Bruce, Debra J, Diaz, Damaris, Gopinathan, Suma, Li, Ling, O’Neill, Emily, Thiel, Mary, Wilson, Alan G. E, Carson, Kenneth G, Powell, David R, Rawlins, David B

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LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice von Powell, David R., Smith, Melinda G., Doree, Deon D., Harris, Angela L., Greer, Jennifer, DaCosta, Christopher M., Thompson, Andrea, Jeter-Jones, Sabrina, Xiong, Wendy, Carson, Kenneth G., Goodwin, Nicole C., Harrison, Bryce A., Rawlins, David B., Strobel, Eric D., Gopinathan, Suma, Wilson, Alan, Mseeh, Faika, Zambrowicz, Brian, Ding, Zhi-Ming

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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity von Salojin, Konstantin V, Hamman, Brian D, Chang, Wei Chun, Jhaver, Kanchan G, Al-Shami, Amin, Crisostomo, Jeannette, Wilkins, Carrie, Digeorge-Foushee, Ann Marie, Allen, Jason, Patel, Nita, Gopinathan, Suma, Zhou, Julia, Nouraldeen, Amr, Jessop, Theodore C, Bagdanoff, Jeffrey T, Augeri, David J, Read, Robert, Vogel, Peter, Swaffield, Jonathan, Wilson, Alan, Platt, Kenneth A, Carson, Kenneth G, Main, Alan, Zambrowicz, Brian P, Oravecz, Tamas

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A naturalistic observation study of medication counseling practices at retail chain pharmacies von Yande, Soham D., Masurkar, Prajakta P., Gopinathan, Suma, Sansgiry, Sujit

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma von Harrison, Bryce A, Almstead, Zheng Y, Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C, Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R, Whitlock, N. Andrew, Gopinathan, Suma, McKnight, Beth, Wang, Shuli, Patel, Nita, Wilson, Alan G. E, Hamman, Brian D, Rice, Dennis S, Rawlins, David B

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Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma von Harrison, Bryce A, Whitlock, N. Andrew, Voronkov, Michael V, Almstead, Zheng Y, Gu, Kun-jian, Mabon, Ross, Gardyan, Michael, Hamman, Brian D, Allen, Jason, Gopinathan, Suma, McKnight, Beth, Crist, Mike, Zhang, Yulian, Liu, Ying, Courtney, Lawrence F, Key, Billie, Zhou, Julia, Patel, Nita, Yates, Phil W, Liu, Qingyun, Wilson, Alan G. E, Kimball, S. David, Crosson, Craig E, Rice, Dennis S, Rawlins, David B

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In vivo toxicology of excipients commonly employed in drug discovery in rats von Gopinathan, Suma, O’Neill, Emily, Rodriguez, Lawrence A., Champ, Rose, Phillips, Megan, Nouraldeen, Amr, Wendt, Mary, Wilson, Alan G.E., Kramer, Jeffrey A.

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484-P: Patient-Reported Burden of Disease in Diabetic Peripheral Neuropathic Pain-Learnings from In-depth Patient Interviews-Substudy of RELIEF-DPN 1 von Gaudiani, Linda M, Sikirica, Slaven, Hardin, Marquette B, Ervin, Claire M, Goss, Diana S, Kosa, Katherine M, Gopinathan, Suma

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Abstract P2-11-09: Comparing the effects of various beta blockers on cardiovascular-related mortality in breast cancer patients von Abdulkareem, Noor M, Chikermane, Soumya G, Gopinathan, Suma, Johnson, Michael L, Trivedi, Meghana V

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Early Toxicology Signal Generation in the Mouse von Kramer, Jeffrey A., O’Neill, Emily, Phillips, Megan E., Bruce, Debra, Smith, Traci, Albright, Melinda M., Bellum, Sairam, Gopinathan, Suma, Heydorn, William E., Liu, Xuemei, Nouraldeen, Amr, Payne, Bobby Joe, Read, Robert, Vogel, Peter, Yu, Xiang-Qing, Wilson, Alan G. E.

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103-OR: LX9211, an Orally-Administered, Non-opioid, AAK1 Inhibitor for Painful Diabetic Peripheral Neuropathy—Results from a Randomized, Double-Blind, Placebo-Controlled, Parallel-... von BUSUI, RODICA, PATEL, ANAND, SANG, CHRISTINE N., GRANOWITZ, CRAIG B., BANKS, PHILLIP L., PIERCE, PHILLIP, SUN, FRANKLIN W., GOPINATHAN, SUMA

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Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacok... von Bundrant, LuAnn, Hunt, Thomas L., Banks, Phil, Gopinathan, Suma, Boehm, Kristi A., Kassler-Taub, Kenneth, Tyle, Praveen, Wilson, Alan, Warner, Chris, Wason, Suman

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Clinical Outcomes Associated with Drug–Drug Interactions of Oral Chemotherapeutic Agents: A Comprehensive Evidence-Based Literature Review von Sharma, Manvi, Vadhariya, Aisha, Chikermane, Soumya, Gopinathan, Suma, Chavez-MacGregor, Mariana, Giordano, Sharon H., Johnson, Michael L., Holmes, Holly M.

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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adap... von Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime... von Bagdanoff, Jeffrey T, Donoviel, Michael S, Nouraldeen, Amr, Carlsen, Marianne, Jessop, Theodore C, Tarver, James, Aleem, Saadat, Dong, Li, Zhang, Haiming, Boteju, Lakmal, Hazelwood, Jill, Yan, Jack, Bednarz, Mark, Layek, Suman, Owusu, Iris B, Gopinathan, Suma, Moran, Liam, Lai, Zhong, Kramer, Jeff, Kimball, S. David, Yalamanchili, Padmaja, Heydorn, William E, Frazier, Kenny S, Brooks, Barbara, Brown, Philip, Wilson, Alan, Sonnenburg, William K, Main, Alan, Carson, Kenneth G, Oravecz, Tamas, Augeri, David J

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethan... von Bagdanoff, Jeffrey T., Donoviel, Michael S., Nouraldeen, Amr, Carlsen, Marianne, Jessop, Theodore C., Tarver, James, Aleem, Saadat, Dong, Li, Zhang, Haiming, Boteju, Lakmal, Hazelwood, Jill, Yan, Jack, Bednarz, Mark, Layek, Suman, Owusu, Iris B., Gopinathan, Suma, Moran, Liam, Lai, Zhong, Kramer, Jeff, Kimball, S. David, Yalamanchili, Padmaja, Heydorn, William E., Frazier, Kenny S., Brooks, Barbara, Brown, Philip, Wilson, Alan, Sonnenburg, William K., Main, Alan, Carson, Kenneth G., Oravecz, Tamas, Augeri, David J.

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Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome von Baugh, Simon D.P., Pabba, Praveen K., Barbosa, Joseph, Coulter, Eric, Desai, Urvi, Gay, Jason P., Gopinathan, Suma, Han, Qiang, Hari, Rajee, Kimball, S. David, Nguyen, Huy V., Ni, Chi-You, Powell, David R., Smith, Arian, Terranova, Kristen M., Wilson, Alan, Yu, Xuan-Chuan, Lombardo, Victoria K.

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Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders von Bagdanoff, Jeffrey T, Donoviel, Michael S, Nouraldeen, Amr, Tarver, James, Fu, Qinghong, Carlsen, Marianne, Jessop, Theodore C, Zhang, Haiming, Hazelwood, Jill, Nguyen, Huy, Baugh, Simon D. P, Gardyan, Michael, Terranova, Kristen M, Barbosa, Joseph, Yan, Jack, Bednarz, Mark, Layek, Suman, Courtney, Lawrence F, Taylor, Jerry, Digeorge-Foushee, Ann Marie, Gopinathan, Suma, Bruce, Debra, Smith, Traci, Moran, Liam, O’Neill, Emily, Kramer, Jeff, Lai, Zhong, Kimball, S. David, Liu, Qingyun, Sun, Weimei, Yu, Sean, Swaffield, Jonathan, Wilson, Alan, Main, Alan, Carson, Kenneth G, Oravecz, Tamas, Augeri, David J

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COMPOUNDS AND METHODS FOR TREATING SPASTICITY von TYLE, Praveen, GOPINATHAN, Suma, YANG, Qi Melissa

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LP‐925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2 von Powell, David R., Smith, Melinda G., Doree, Deon D., Harris, Angela L., Xiong, Wendy W., Mseeh, Faika, Wilson, Alan, Gopinathan, Suma, Diaz, Damaris, Goodwin, Nicole C., Harrison, Bryce, Strobel, Eric, Rawlins, David B., Carson, Ken, Zambrowicz, Brian, Ding, Zhi‐Ming

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