Selectivity through Targeted Protein Degradation (TPD) von Gopalsamy, Ariamala

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Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue von Fadeyi, Olugbeminiyi O, Hoth, Lise R, Choi, Chulho, Feng, Xidong, Gopalsamy, Ariamala, Hett, Erik C, Kyne, Robert E, Robinson, Ralph P, Jones, Lyn H

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Selectivity through Targeted Protein Degradation (TPD): Miniperspective von Gopalsamy, Ariamala

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Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes von Hett, Erik C, Xu, Hua, Geoghegan, Kieran F, Gopalsamy, Ariamala, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Parikh, Mihir D, Liu, Shenping, Roberts, Lee, Robinson, Ralph P, Tones, Michael A, Jones, Lyn H

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Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells von Xu, Hua, Gopalsamy, Ariamala, Hett, Erik C, Salter, Shores, Aulabaugh, Ann, Kyne, Robert E, Pierce, Betsy, Jones, Lyn H

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Identification of pyrimidine derivatives as hSMG-1 inhibitors von Gopalsamy, Ariamala, Bennett, Eric M., Shi, Mengxiao, Zhang, Wei-Guo, Bard, Joel, Yu, Ker

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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-... von Fensome, Andrew, Ambler, Catherine M, Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F, Chrencik, Jill, Clark, James D, Dowty, Martin E, Efremov, Ivan V, Flick, Andrew, Gerstenberger, Brian S, Gopalsamy, Ariamala, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Jussif, Jason, Knafels, John D, Limburg, David C, Lin, David, Lin, Tsung H, Pierce, Betsy S, Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T, Telliez, Jean-Baptiste, Trujillo, John I, Vajdos, Felix F, Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying

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A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation von Bodine, Peter V.N, Stauffer, Barbara, Ponce-de-Leon, Helga, Bhat, Ramesh A, Mangine, Annamarie, Seestaller-Wehr, Laura M, Moran, Robert A, Billiard, Julia, Fukayama, Shoichi, Komm, Barry S, Pitts, Keith, Krishnamurthy, Girija, Gopalsamy, Ariamala, Shi, Mengxiao, Kern, Jeffrey C, Commons, Thomas J, Woodworth, Richard P, Wilson, Matthew A, Welmaker, Gregory S, Trybulski, Eugene J, Moore, William J

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In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels von Cherry, Jonathan J, DiDonato, Christine J, Androphy, Elliot J, Calo, Alessandro, Potter, Kyle, Custer, Sara K, Du, Sarah, Foley, Timothy L, Gopalsamy, Ariamala, Reedich, Emily J, Gordo, Susana M, Gordon, William, Hosea, Natalie, Jones, Lyn H, Krizay, Daniel K, LaRosa, Gregory, Li, Hongxia, Mathur, Sachin, Menard, Carol A, Patel, Paraj, Ramos-Zayas, Rebeca, Rietz, Anne, Rong, Haojing, Zhang, Baohong, Tones, Michael A

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Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90 von Gopalsamy, Ariamala, Shi, Mengxiao, Golas, Jennifer, Vogan, Erik, Jacob, Jaison, Johnson, Mark, Lee, Frederick, Nilakantan, Ramaswamy, Petersen, Roseann, Svenson, Kristin, Chopra, Rajiv, Tam, May S, Wen, Yingxia, Ellingboe, John, Arndt, Kim, Boschelli, Frank

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Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors von Gopalsamy, Ariamala, Shi, Mengxiao, Boschelli, Diane H, Williamson, Robert, Olland, Andrea, Hu, Yongbo, Krishnamurthy, Girija, Han, Xin, Arndt, Kim, Guo, Bing

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Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors von Ni, Yike, Gopalsamy, Ariamala, Cole, Derek, Hu, Yonghan, Denny, Rajiah, Ipek, Manus, Liu, Julie, Lee, Julie, Hall, J. Perry, Luong, Michael, Telliez, Jean-Baptiste, Lin, Lih-Ling

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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS von Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Jr, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

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Photocatalyzed Decarboxylative Addition of N‑Substituted Acetic Acids to Aldehydes von Jin, Bo, Gopalsamy, Ariamala, Peng, Bo, Sha, Li, Tentarelli, Sharon, Gingipalli, Lakshmaiah

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Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors von Shi, Mengxiao, Stauffer, Barbara, Bhat, Ramesh, Billiard, Julia, Ponce-de-Leon, Helga, Seestaller-Wehr, Laura, Fukayama, Shoichi, Mangine, Annamarie, Moran, Robert, Krishnamurthy, Girija, Bodine, Peter, Gopalsamy, Ariamala

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Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase von HOWE, Anita Y. M, BLOOM, Johnathan, GORCZYCA, William P, HERRRNANN, Steve, JOHANN, Stephen, XIAOQUN JIANG, KIMBERLAND, Michelle L, KRISNAMURTHY, Girija, OLSON, Matthew, ORLOWSKI, Mark, SWANBERG, Steve, THOMPSON, Ian, BALDICK, Carl J, THORN, Megan, DEL VECCHIO, Alfred, YOUNG, Dorothy C, VAN ZEIJL, Marja, ELLINGBOE, John W, UPESLACIS, Janis, COLLETT, Marc, MANSOUR, Tarek S, O'CONNELL, John F, BENETATOS, Christopher A, HUIMING CHENG, CHRISTENSEN, Joel S, CHUNDURU, Srinivas K, COBURN, Glen A, FELD, Boris, GOPALSAMY, Ariamala

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Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment von Connors, William, DeKorte, Ryan, Lucas, Simon C. C., Gopalsamy, Ariamala, Ziegler, Robert E.

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Photoredox Catalysis: 1,4-Conjugate Addition of N‑Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of N‑Substituted Acetic Acids von Gingipalli, Lakshmaiah, Boerth, Jeffrey, Emmons, David, Grebe, Tyler, Hatoum-Mokdad, Holia, Peng, Bo, Sha, Li, Tentarelli, Sharon, Wang, Haixia, Wu, Ye, Zheng, XiaoLan, Edmondson, Scott, Gopalsamy, Ariamala

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease von Gopalsamy, Ariamala, Aulabaugh, Ann E, Barakat, Amey, Beaumont, Kevin C, Cabral, Shawn, Canterbury, Daniel P, Casimiro-Garcia, Agustin, Chang, Jeanne S, Chen, Ming Z, Choi, Chulho, Dow, Robert L, Fadeyi, Olugbeminiyi O, Feng, Xidong, France, Scott P, Howard, Roger M, Janz, Jay M, Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H, King-Ahmad, Amanda, Knee, Kelly M, Kohrt, Jeffrey T, Limberakis, Chris, Liras, Spiros, Martinez, Carlos A, McClure, Kim F, Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J, O'Connell, Thomas N, Parikh, Mihir D, Piotrowski, David W, Plotnikova, Olga, Robinson, Ralph P, Sahasrabudhe, Parag V, Sharma, Raman, Thuma, Benjamin A, Vasa, Dipy, Wei, Liuqing, Wenzel, A Zane, Withka, Jane M, Xiao, Jun, Yayla, Hatice G

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Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1 von Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gifford, Roger S., Gopalsamy, Ariamala, Hegen, Martin, Jussif, Jason, Limburg, David C., Lin, Tsung H., Pierce, Betsy S., Sharma, Raman, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin

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