Identifying a high fraction of the human genome to be under selective constraint using GERP von Davydov, Eugene V, Goode, David L, Sirota, Marina, Cooper, Gregory M, Sidow, Arend, Batzoglou, Serafim

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Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors von Trigos, Anna S., Pearson, Richard B., Papenfuss, Anthony T., Goode, David L.

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Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments von Feng, Yuzhou, Yang, Tianpei, Zhu, John, Li, Mabel, Doyle, Maria, Ozcoban, Volkan, Bass, Greg T., Pizzolla, Angela, Cain, Lachlan, Weng, Sirui, Pasam, Anupama, Kocovski, Nikolce, Huang, Yu-Kuan, Keam, Simon P., Speed, Terence P., Neeson, Paul J., Pearson, Richard B., Sandhu, Shahneen, Goode, David L., Trigos, Anna S.

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PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma von Chan, Lok Hang, Wang, Peihan, Abuhammad, Shatha, Lim, Lydia Rui Jia, Cursons, Joseph, Sheppard, Karen E, Goode, David L

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How the evolution of multicellularity set the stage for cancer von Trigos, Anna S, Pearson, Richard B, Papenfuss, Anthony T, Goode, David L

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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L., Bedo, Justin, McCabe, Mark J., Pajic, Marina, Croucher, David R., Rajal, Alvaro Gonzalez, Junankar, Simon R., Saunders, Darren N., Lobachevsky, Pavel, Papenfuss, Anthony T., Nessem, Danielle, Nobis, Max, Warren, Sean C., Timpson, Paul, Cowley, Mark, Vargas, Ana C., Qiu, Min R., Generali, Daniele G., Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M., Long, Georgina V., Blay, Jean-Yves, Thomas, David M.

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Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer von Trigos, Anna S, Pearson, Richard B, Papenfuss, Anthony T, Goode, David L

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The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes von Montgomery, Stephen B, Goode, David L, Kvikstad, Erika, Albers, Cornelis A, Zhang, Zhengdong D, Mu, Xinmeng Jasmine, Ananda, Guruprasad, Howie, Bryan, Karczewski, Konrad J, Smith, Kevin S, Anaya, Vanessa, Richardson, Rhea, Davis, Joe, MacArthur, Daniel G, Sidow, Arend, Duret, Laurent, Gerstein, Mark, Makova, Kateryna D, Marchini, Jonathan, McVean, Gil, Lunter, Gerton

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Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins von Trigos, Anna S, Bongiovanni, Felicia, Zhang, Yangyi, Zethoven, Maia, Tothill, Richard, Pearson, Richard, Papenfuss, Anthony T, Goode, David L

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Abstract 1869 Using open note exams when teaching Biochemistry I von Goode, David

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Androgen receptor enhancer amplification in matched patient‐derived xenografts of primary and castrate‐resistant prostate cancer von Porter, Laura H, Bakshi, Andrew, Pook, David, Clark, Ashlee, Clouston, David, Kourambas, John, Goode, David L, Risbridger, Gail P, Taylor, Renea A, Lawrence, Mitchell G

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High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort von Mitchell, Gillian, Ballinger, Mandy L, Wong, Stephen, Hewitt, Chelsee, James, Paul, Young, Mary-Anne, Cipponi, Arcadi, Pang, Tiffany, Goode, David L, Dobrovic, Alex, Thomas, David M

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Single-nucleotide evolutionary constraint scores highlight disease-causing mutations von Cooper, Gregory M, Goode, David L, Ng, Sarah B, Sidow, Arend, Bamshad, Michael J, Shendure, Jay, Nickerson, Deborah A

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Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy von Lawrence, Mitchell G., Obinata, Daisuke, Sandhu, Shahneen, Selth, Luke A., Wong, Stephen Q., Porter, Laura H., Lister, Natalie, Pook, David, Pezaro, Carmel J., Goode, David L., Rebello, Richard J., Clark, Ashlee K., Papargiris, Melissa, Van Gramberg, Jenna, Hanson, Adrienne R., Banks, Patricia, Wang, Hong, Niranjan, Birunthi, Keerthikumar, Shivakumar, Hedwards, Shelley, Huglo, Alisee, Yang, Rendong, Henzler, Christine, Li, Yingming, Lopez-Campos, Fernando, Castro, Elena, Toivanen, Roxanne, Azad, Arun, Bolton, Damien, Goad, Jeremy, Grummet, Jeremy, Harewood, Laurence, Kourambas, John, Lawrentschuk, Nathan, Moon, Daniel, Murphy, Declan G., Sengupta, Shomik, Snow, Ross, Thorne, Heather, Mitchell, Catherine, Pedersen, John, Clouston, David, Norden, Sam, Ryan, Andrew, Dehm, Scott M., Tilley, Wayne D., Pearson, Richard B., Hannan, Ross D., Frydenberg, Mark, Furic, Luc, Taylor, Renea A., Risbridger, Gail P.

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Assessment of masticatory function of mandibular implant-supported overdenture wearers: A 3-year prospective study von Khalid, Taimur, Yunus, Norsiah, Ibrahim, Norliza, Saleh, Nosizana Binti Mohd, Goode, David, Masood, Mohd

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PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition von Peterson, Quinn P., Goode, David R., West, Diana C., Ramsey, Kara N., Lee, Joy J.Y., Hergenrother, Paul J.

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ABC of Major Trauma: Rescue, Resuscitation with Imaging, and Rehabilitation von Driscoll, Peter Anthony, Skinner, David V, Goode, Peter N

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Co‐targeting BET, CBP, and p300 inhibits neuroendocrine signalling in androgen receptor‐null prostate cancer von Choo, Nicholas, Keerthikumar, Shivakumar, Ramm, Susanne, Ashikari, Daisaku, Teng, Linda, Niranjan, Birunthi, Hedwards, Shelley, Porter, Laura H, Goode, David L, Simpson, Kaylene J, Taylor, Renea A, Risbridger, Gail P, Lawrence, Mitchell G

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CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition von Lawrence, Mitchell G, Porter, Laura H, Choo, Nicholas, Pook, David, Grummet, Jeremy P, Pezaro, Carmel J, Sandhu, Shahneen, Ramm, Susanne, Luu, Jennii, Bakshi, Andrew, Goode, David L, Sanij, Elaine, Pearson, Richard B, Hannan, Ross D, Simpson, Kaylene J, Taylor, Renea A, Risbridger, Gail P, Furic, Luc

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis von Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B

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