Discovery of (R)‑1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid‑1 (TRPV1)... von Voight, Eric A, Gomtsyan, Arthur R, Daanen, Jerome F, Perner, Richard J, Schmidt, Robert G, Bayburt, Erol K, DiDomenico, Stanley, McDonald, Heath A, Puttfarcken, Pamela S, Chen, Jun, Neelands, Torben R, Bianchi, Bruce R, Han, Ping, Reilly, Regina M, Franklin, Pamela H, Segreti, Jason A, Nelson, Richard A, Su, Zhi, King, Andrew J, Polakowski, James S, Baker, Scott J, Gauvin, Donna M, Lewis, LaGeisha R, Mikusa, Joseph P, Joshi, Shailen K, Faltynek, Connie R, Kym, Philip R, Kort, Michael E

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia von Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.

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Vanilloid receptor TRPV1 in drug discovery: targeting pain and other pathological disorders von Gomtsyan, Arthur, Faltynek, Connie R

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Additive Antinociceptive Effects of the Selective Nav1.8 Blocker A-803467 and Selective TRPV1 Antagonists in Rat Inflammatory and Neuropathic Pain Models von Joshi, S.K, Honore, Prisca, Hernandez, Gricelda, Schmidt, Robert, Gomtsyan, Arthur, Scanio, Marc, Kort, Michael, Jarvis, Michael F

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Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists von Perner, Richard J., Koenig, John R., DiDomenico, Stanley, Gomtsyan, Arthur, Schmidt, Robert G., Lee, Chih-Hung, Hsu, Margaret C., McDonald, Heath A., Gauvin, Donna M., Joshi, Shailen, Turner, Teresa M., Reilly, Regina M., Kym, Philip R., Kort, Michael E.

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Targeting TRP channels: beyond TRPV1 von Gomtsyan, Arthur, Szallasi, Arpad

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Asymmetric synthesis of enantiomerically pure and diversely functionalized cyclopropanes von Hanessian, Stephen, Andreotti, Daniele, Gomtsyan, Arthur

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design von Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong

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Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature von Reilly, Regina M, McDonald, Heath A, Puttfarcken, Pamela S, Joshi, Shailen K, Lewis, LaGeisha, Pai, Madhavi, Franklin, Pamela H, Segreti, Jason A, Neelands, Torben R, Han, Ping, Chen, Jun, Mantyh, Patrick W, Ghilardi, Joseph R, Turner, Teresa M, Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Kort, Michael E, Faltynek, Connie R, Kym, Philip R

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Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid‑3 (TRPV3) Antagonist von Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Dart, Michael J, Kym, Philip R

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TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats von McGaraughty, Steve, Chu, Katharine L, Xu, Jun, Leys, Laura, Radek, Richard J, Dart, Michael J, Gomtsyan, Arthur, Schmidt, Robert G, Kym, Philip R, Brederson, Jill-Desiree

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Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction von Gomtsyan, Arthur

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Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management von Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Surowy, Carol S, Honore, Prisca, Marsh, Kennan C, Hannick, Steven M, McDonald, Heath A, Wetter, Jill M, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung

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Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists von Gomtsyan, Arthur, Schmidt, Robert G, Bayburt, Erol K, Gfesser, Gregory A, Voight, Eric A, Daanen, Jerome F, Schmidt, Diana L, Cowart, Marlon D, Liu, Huaqing, Altenbach, Robert J, Kort, Michael E, Clapham, Bruce, Cox, Phil B, Shrestha, Anurupa, Henry, Rodger, Whittern, David N, Reilly, Regina M, Puttfarcken, Pamela S, Brederson, Jill-Desiree, Song, Ping, Li, Bin, Huang, Susan M, McDonald, Heath A, Neelands, Torben R, McGaraughty, Steve P, Gauvin, Donna M, Joshi, Shailen K, Banfor, Patricia N, Segreti, Jason A, Shebley, Mohamad, Faltynek, Connie R, Dart, Michael J, Kym, Philip R

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Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain:  Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline... von Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung

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Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substit... von Hanessian, Stephen, Gomtsyan, Arthur, Payne, Andrew, Herve, Yolande, Beaudoin, Serge

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Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists von Schmidt, Robert G., Bayburt, Erol K., Latshaw, Steven P., Koenig, John R., Daanen, Jerome F., McDonald, Heath A., Bianchi, Bruce R., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Lee, Chih-Hung, Faltynek, Connie R., Gomtsyan, Arthur

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TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats von Gomtsyan, Arthur, McDonald, Heath A, Schmidt, Robert G, Daanen, Jerome F, Voight, Eric A, Segreti, Jason A, Puttfarcken, Pamela S, Reilly, Regina M, Kort, Michael E, Dart, Michael J, Kym, Philip R

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Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted Chirons von Hanessian, Stephen, Gomtsyan, Arthur, Malek, Nadia

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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists von Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Drizin, Irene, Zheng, Guo Zhu, Turner, Sean C, Jinkerson, Tammie, Brown, Brian S, Keddy, Ryan G, Lukin, Kurill, McDonald, Heath A, Honore, Prisca, Mikusa, Joe, Marsh, Kennan C, Wetter, Jill M, St. George, Karen, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung

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