Genomic evolution of cancer models: perils and opportunities von Ben-David, Uri, Beroukhim, Rameen, Golub, Todd R.

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Copper induces cell death by targeting lipoylated TCA cycle proteins von Tsvetkov, Peter, Coy, Shannon, Petrova, Boryana, Dreishpoon, Margaret, Verma, Ana, Abdusamad, Mai, Rossen, Jordan, Joesch-Cohen, Lena, Humeidi, Ranad, Spangler, Ryan D, Eaton, John K, Frenkel, Evgeni, Kocak, Mustafa, Corsello, Steven M, Lutsenko, Svetlana, Kanarek, Naama, Santagata, Sandro, Golub, Todd R

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A metastasis map of human cancer cell lines von Jin, Xin, Demere, Zelalem, Nair, Karthik, Ali, Ahmed, Ferraro, Gino B., Natoli, Ted, Deik, Amy, Petronio, Lia, Tang, Andrew A., Zhu, Cong, Wang, Li, Rosenberg, Danny, Mangena, Vamsi, Roth, Jennifer, Chung, Kwanghun, Jain, Rakesh K., Clish, Clary B., Vander Heiden, Matthew G., Golub, Todd R.

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Genetic and transcriptional evolution alters cancer cell line drug response von Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.

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The Drug Repurposing Hub: a next-generation drug library and information resource von Corsello, Steven M, Bittker, Joshua A, Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E, Johnston, Stephen E, Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C, Subramanian, Aravind, Golub, Todd R

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Cas9 activates the p53 pathway and selects for p53-inactivating mutations von Enache, Oana M., Rendo, Veronica, Abdusamad, Mai, Lam, Daniel, Davison, Desiree, Pal, Sangita, Currimjee, Naomi, Hess, Julian, Pantel, Sasha, Nag, Anwesha, Thorner, Aaron R., Doench, John G., Vazquez, Francisca, Beroukhim, Rameen, Golub, Todd R., Ben-David, Uri

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Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells von Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer von Polak, Paz, Kim, Jaegil, Braunstein, Lior Z, Karlic, Rosa, Haradhavala, Nicholas J, Tiao, Grace, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W, Kamburov, Atanas, Maruvka, Yosef E, Leshchiner, Ignaty, Lander, Eric S, Golub, Todd R, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S, Batra, Rajbir N, Caldas, Carlos, Haber, Daniel A, Laird, Peter W, Shen, Hui, Ellisen, Leif W, D'Andrea, Alan D, Chanock, Stephen J, Foulkes, William D, Getz, Gad

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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map von Smith, Ian, Greenside, Peyton G, Natoli, Ted, Lahr, David L, Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E, Golub, Todd R, Subramanian, Aravind, Doench, John G

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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration von McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

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The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research von Painter, Corrie A., Jain, Esha, Tomson, Brett N., Dunphy, Michael, Stoddard, Rachel E., Thomas, Beena S., Damon, Alyssa L., Shah, Shahrayz, Kim, Dewey, Gómez Tejeda Zañudo, Jorge, Hornick, Jason L., Chen, Yen-Lin, Merriam, Priscilla, Raut, Chandrajit P., Demetri, George D., Van Tine, Brian A., Lander, Eric S., Golub, Todd R., Wagle, Nikhil

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Protection of tissue physicochemical properties using polyfunctional crosslinkers von Park, Young-Gyun, Sohn, Chang Ho, Chen, Ritchie, McCue, Margaret, Yun, Dae Hee, Drummond, Gabrielle T, Ku, Taeyun, Evans, Nicholas B, Oak, Hayeon Caitlyn, Trieu, Wendy, Choi, Heejin, Jin, Xin, Lilascharoen, Varoth, Wang, Ji, Truttmann, Matthias C, Qi, Helena W, Ploegh, Hidde L, Golub, Todd R, Chen, Shih-Chi, Frosch, Matthew P, Kulik, Heather J, Lim, Byung Kook, Chung, Kwanghun

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Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary med... von Green, Michael R., Monti, Stefano, Rodig, Scott J., Juszczynski, Przemyslaw, Currie, Treeve, O'Donnell, Evan, Chapuy, Bjoern, Takeyama, Kunihiko, Neuberg, Donna, Golub, Todd R., Kutok, Jeffery L., Shipp, Margaret A.

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Comprehensive assessment of cancer missense mutation clustering in protein structures von Kamburov, Atanas, Lawrence, Michael S., Polak, Paz, Leshchiner, Ignaty, Lage, Kasper, Golub, Todd R., Lander, Eric S., Getz, Gad

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A molecular signature of metastasis in primary solid tumors von Ramaswamy, Sridhar, Golub, Todd R, Ross, Ken N, Lander, Eric S

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Impaired microRNA processing enhances cellular transformation and tumorigenesis von Jacks, Tyler, Kumar, Madhu S, Lu, Jun, Mercer, Kim L, Golub, Todd R

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Recurrent and functional regulatory mutations in breast cancer von Rheinbay, Esther, Parasuraman, Prasanna, Grimsby, Jonna, Tiao, Grace, Engreitz, Jesse M., Kim, Jaegil, Lawrence, Michael S., Taylor-Weiner, Amaro, Rodriguez-Cuevas, Sergio, Rosenberg, Mara, Hess, Julian, Stewart, Chip, Maruvka, Yosef E., Stojanov, Petar, Cortes, Maria L., Seepo, Sara, Cibulskis, Carrie, Tracy, Adam, Pugh, Trevor J., Lee, Jesse, Zheng, Zongli, Ellisen, Leif W., Iafrate, A. John, Boehm, Jesse S., Gabriel, Stacey B., Meyerson, Matthew, Golub, Todd R., Baselga, Jose, Hidalgo-Miranda, Alfredo, Shioda, Toshi, Bernards, Andre, Lander, Eric S., Getz, Gad

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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets von Dempster, Joshua M., Pacini, Clare, Pantel, Sasha, Behan, Fiona M., Green, Thomas, Krill-Burger, John, Beaver, Charlotte M., Younger, Scott T., Zhivich, Victor, Najgebauer, Hanna, Allen, Felicity, Gonçalves, Emanuel, Shepherd, Rebecca, Doench, John G., Yusa, Kosuke, Vazquez, Francisca, Parts, Leopold, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco

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Targetable genetic features of primary testicular and primary central nervous system lymphomas von Chapuy, Bjoern, Roemer, Margaretha G.M., Stewart, Chip, Tan, Yuxiang, Abo, Ryan P., Zhang, Liye, Dunford, Andrew J., Meredith, David M., Thorner, Aaron R., Jordanova, Ekaterina S., Liu, Gang, Feuerhake, Friedrich, Ducar, Matthew D., Illerhaus, Gerald, Gusenleitner, Daniel, Linden, Erica A., Sun, Heather H., Homer, Heather, Aono, Miyuki, Pinkus, Geraldine S., Ligon, Azra H., Ligon, Keith L., Ferry, Judith A., Freeman, Gordon J., van Hummelen, Paul, Golub, Todd R., Getz, Gad, Rodig, Scott J., de Jong, Daphne, Monti, Stefano, Shipp, Margaret A.

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis von Rampal, Raajit, Al-Shahrour, Fatima, Abdel-Wahab, Omar, Patel, Jay P., Brunel, Jean-Philippe, Mermel, Craig H., Bass, Adam J., Pretz, Jennifer, Ahn, Jihae, Hricik, Todd, Kilpivaara, Outi, Wadleigh, Martha, Busque, Lambert, Gilliland, D. Gary, Golub, Todd R., Ebert, Benjamin L., Levine, Ross L.

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