Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a... von Fitzgerald, Kevin, Dr, Frank-Kamenetsky, Maria, PhD, Shulga-Morskaya, Svetlana, MSc, Liebow, Abigail, BS, Bettencourt, Brian R, PhD, Sutherland, Jessica E, PhD, Hutabarat, Renta M, PhD, Clausen, Valerie A, PhD, Karsten, Verena, PhD, Cehelsky, Jeffrey, MBA, Nochur, Saraswathy V, PhD, Kotelianski, Victor, MD, Horton, Jay, MD, Mant, Timothy, MD, Chiesa, Joseph, MD, Ritter, James, MD, Munisamy, Malathy, MD, Vaishnaw, Akshay K, MD, Gollob, Jared A, MD, Simon, Amy, MD

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Safety profile of RNAi nanomedicines von Barros, Scott A., Gollob, Jared A.

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randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus von DeVincenzo, John, Lambkin-Williams, Robert, Wilkinson, Tom, Cehelsky, Jeffrey, Nochur, Sara, Walsh, Edward, Meyers, Rachel, Gollob, Jared, Vaishnaw, Akshay

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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial von Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.

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Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study von Suhr, Ole B, Coelho, Teresa, Buades, Juan, Pouget, Jean, Conceicao, Isabel, Berk, John, Schmidt, Hartmut, Waddington-Cruz, Márcia, Campistol, Josep M, Bettencourt, Brian R, Vaishnaw, Akshay, Gollob, Jared, Adams, David

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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate von Zimmermann, Tracy S., Karsten, Verena, Chan, Amy, Chiesa, Joseph, Boyce, Malcolm, Bettencourt, Brian R., Hutabarat, Renta, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared

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Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy von Adams, David, Suhr, Ole B, Dyck, Peter J, Litchy, William J, Leahy, Raina G, Chen, Jihong, Gollob, Jared, Coelho, Teresa

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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients von Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

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Rapid progression of familial amyloidotic polyneuropathy: A multinational natural history study von Adams, David, Coelho, Teresa, Obici, Laura, Merlini, Giampaolo, Mincheva, Zoia, Suanprasert, Narupat, Bettencourt, Brian R, Gollob, Jared A, Gandhi, Pritesh J, Litchy, William J, Dyck, Peter J

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Role of Raf Kinase in Cancer: Therapeutic Potential of Targeting the Raf/MEK/ERK Signal Transduction Pathway von Gollob, Jared A., Wilhelm, Scott, Carter, Chris, Kelley, Susan L.

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RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus von ZAMORA, Martin R, BUDEV, Marie, GOLLOB, Jared A, GLANVILLE, Allan R, ROLFE, Mark, GOTTLIEB, Jens, HUMAR, Atul, DEVINCENZO, John, VAISHNAW, Akshay, CEHELSKY, Jeffrey, ALBERT, Gary, NOCHUR, Sara

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First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement von Tabernero, Josep, Shapiro, Geoffrey I, LoRusso, Patricia M, Cervantes, Andres, Schwartz, Gary K, Weiss, Glen J, Paz-Ares, Luis, Cho, Daniel C, Infante, Jeffrey R, Alsina, Maria, Gounder, Mrinal M, Falzone, Rick, Harrop, Jamie, White, Amy C Seila, Toudjarska, Iva, Bumcrot, David, Meyers, Rachel E, Hinkle, Gregory, Svrzikapa, Nenad, Hutabarat, Renta M, Clausen, Valerie A, Cehelsky, Jeffrey, Nochur, Saraswathy V, Gamba-Vitalo, Christina, Vaishnaw, Akshay K, Sah, Dinah W Y, Gollob, Jared A, Burris, 3rd, Howard A

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A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis von Coelho, Teresa, Adams, David, Conceicao, Isabel, Waddington-Cruz, Marcia, Schmidt, Hartmut H., Buades, Juan, Campistol, Josep, Berk, John L., Polydefkis, Michael, Wang, Jing Jing, Chen, Jihong, Sweetser, Marianne T., Gollob, Jared, Suhr, Ole B.

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Phase II Trial of Sorafenib Plus Interferon Alfa-2b As First- or Second-Line Therapy in Patients With Metastatic Renal Cell Cancer von GOLLOB, Jared A, KIMRYN RATHMELL, W, RICHMOND, Tina M, MARINO, Christine B, MILLER, Elizabeth K, GRIGSON, Gayle, WATKINS, Catharine, LIN GU, PETERSON, Bercedis L, WRIGHT, John J

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Safety, Pharmacokinetics, and Activity of ABX-EGF, a Fully Human Anti–Epidermal Growth Factor Receptor Monoclonal Antibody in Patients With Metastatic Renal Cell Cancer von ROWINSKY, Eric K, SCHWARTZ, Garry H, ARENAS, Rosalin, FOON, Kenneth A, SCHWAB, Gisela, DUTCHER, Janice, GOLLOB, Jared A, THOMPSON, John A, VOGELZANG, Nicholas J, FIGLIN, Robert, BUKOWSKI, Ronald, HAAS, Naomi, LOCKBAUM, Pamela, LI, Yu-Ping

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Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma von GOLLOB, Jared A, SCIAMBI, Catherine J, PETERSON, Bercedis L, RICHMOND, Tina, THORESON, Monica, MORAN, Kelly, DRESSMAN, Holly K, JELINEK, Jaroslav, ISSA, Jean-Pierre J

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Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells von Niemietz, Christoph J, Sauer, Vanessa, Stella, Jacqueline, Fleischhauer, Lutz, Chandhok, Gursimran, Guttmann, Sarah, Avsar, Yesim, Guo, Shuling, Ackermann, Elizabeth J, Gollob, Jared, Monia, Brett P, Zibert, Andree, Schmidt, Hartmut H-J

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Decitabine Up-regulates S100A2 Expression and Synergizes with IFN-γ to Kill Uveal Melanoma Cells von GOLLOB, Jared A, SCIAMBI, Catherine J

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603 Targeted STAT3 degradation leads to remodeling of an immunosuppressive tumor microenvironment and subsequent sensitization to immune checkpoint therapy von Dey, Joyoti, Liu, Phillip, Mayo, Michele, Karnik, Rahul, Yang, Bin, Dixit, Vaishali, Jeong, Jieun, Gollob, Jared, Savi, Chris De

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Phase I Trial of Concurrent Twice-Weekly Recombinant Human Interleukin-12 Plus Low-Dose IL-2 in Patients With Melanoma or Renal Cell Carcinoma von GOLLOB, Jared A, VEENSTRA, Korina G, PARKER, Robert A, MIER, James W, MCDERMOTT, David F, CLANCY, Daniel, TUTIN, Linda, KOON, Henry, ATKINS, Michael B

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