Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing von Shimelis, Hermela, LaDuca, Holly, Hu, Chunling, Hart, Steven N, Na, Jie, Thomas, Abigail, Akinhanmi, Margaret, Moore, Raymond M, Brauch, Hiltrud, Cox, Angela, Eccles, Diana M, Ewart-Toland, Amanda, Fasching, Peter A, Fostira, Florentia, Garber, Judy, Godwin, Andrew K, Konstantopoulou, Irene, Nevanlinna, Heli, Sharma, Priyanka, Yannoukakos, Drakoulis, Yao, Song, Feng, Bing-Jian, Tippin Davis, Brigette, Lilyquist, Jenna, Pesaran, Tina, Goldgar, David E, Polley, Eric C, Dolinsky, Jill S, Couch, Fergus J

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The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort von Hu, Chunling, Polley, Eric C, Yadav, Siddhartha, Lilyquist, Jenna, Shimelis, Hermela, Na, Jie, Hart, Steven N, Goldgar, David E, Shah, Swati, Pesaran, Tina, Dolinsky, Jill S, LaDuca, Holly, Couch, Fergus J

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Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls von Lilyquist, Jenna, LaDuca, Holly, Polley, Eric, Davis, Brigette Tippin, Shimelis, Hermela, Hu, Chunling, Hart, Steven N., Dolinsky, Jill S., Couch, Fergus J., Goldgar, David E.

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Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results von Pritzlaff, Mary, Summerour, Pia, McFarland, Rachel, Li, Shuwei, Reineke, Patrick, Dolinsky, Jill S., Goldgar, David E., Shimelis, Hermela, Couch, Fergus J., Chao, Elizabeth C., LaDuca, Holly

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A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk pa... von LaDuca, Holly, Polley, Eric C., Yussuf, Amal, Hoang, Lily, Gutierrez, Stephanie, Hart, Steven N., Yadav, Siddhartha, Hu, Chunling, Na, Jie, Goldgar, David E., Fulk, Kelly, Smith, Laura Panos, Horton, Carolyn, Profato, Jessica, Pesaran, Tina, Gau, Chia-Ling, Pronold, Melissa, Davis, Brigette Tippin, Chao, Elizabeth C., Couch, Fergus J., Dolinsky, Jill S.

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A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes von Easton, Douglas F., Deffenbaugh, Amie M., Pruss, Dmitry, Frye, Cynthia, Wenstrup, Richard J., Allen-Brady, Kristina, Tavtigian, Sean V., Monteiro, Alvaro N.A., Iversen, Edwin S., Couch, Fergus J., Goldgar, David E.

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Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance von Richardson, Marcy E., Hu, Chunling, Lee, Kun Y., LaDuca, Holly, Fulk, Kelly, Durda, Kate M., Deckman, Ashley M., Goldgar, David E., Monteiro, Alvaro N.A., Gnanaolivu, Rohan, Hart, Steven N., Polley, Eric C., Chao, Elizabeth, Pesaran, Tina, Couch, Fergus J.

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Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches von Guidugli, Lucia, Shimelis, Hermela, Masica, David L., Pankratz, Vernon S., Lipton, Gary B., Singh, Namit, Hu, Chunling, Monteiro, Alvaro N.A., Lindor, Noralane M., Goldgar, David E., Karchin, Rachel, Iversen, Edwin S., Couch, Fergus J.

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Heritable DNA methylation marks associated with susceptibility to breast cancer von Joo, Jihoon E., Dowty, James G., Milne, Roger L., Wong, Ee Ming, Dugué, Pierre-Antoine, English, Dallas, Hopper, John L., Goldgar, David E., Giles, Graham G., Southey, Melissa C.

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A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS) von Lindor, Noralane M., Guidugli, Lucia, Wang, Xianshu, Vallée, Maxime P., Monteiro, Alvaro N. A., Tavtigian, Sean, Goldgar, David E., Couch, Fergus J.

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Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers von PHILLIPS, Kelly-Anne, MILNE, Roger L, BUYS, Saundra S, ANDRIEU, Nadine, NOGUES, Catherine, STOPPA-LYONNET, Dominique, BONADONA, Valérie, PUJOL, Pascal, MCLACHLAN, Sue Anne, JOHN, Esther M, HOONING, Maartje J, SEYNAEVE, Caroline, ROOKUS, Matti A, TOLLENAAR, Rob A. E. M, GOLDGAR, David E, TERRY, Mary Beth, CALDES, Trinidad, WEIDEMAN, Prue C, ANDRULIS, Irene L, SINGER, Christian F, BIRCH, Kate, SIMARD, Jacques, SOUTHEY, Melissa C, DALY, Mary B, OLSSON, Håkan L, JAKUBOWSKA, Anna, OLAH, Edith, GERDES, Anne-Marie, FORETOVA, Lenka, HOPPER, John L, ANTONIOU, Antonis C, PEOCK, Susan, FROST, Debra, EASTON, Douglas F, ELLIS, Steve, FRIEDLANDER, Michael L

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Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models von Hart, Steven N., Hoskin, Tanya, Shimelis, Hermela, Moore, Raymond M., Feng, Bingjian, Thomas, Abigail, Lindor, Noralane M., Polley, Eric C., Goldgar, David E., Iversen, Edwin, Monteiro, Alvaro N.A., Suman, Vera J., Couch, Fergus J.

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BRCA1/2 Sequence Variants of Uncertain Significance: A Primer for Providers to Assist in Discussions and in Medical Management von Lindor, Noralane M., Goldgar, David E., Tavtigian, Sean V., Plon, Sharon E., Couch, Fergus J.

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A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity von GUIDUGLI, Lucia, PANKRATZ, Vernon S, SINGER, Christian, TONIN, Patricia N, LINDOR, Noralane M, GOLDGAR, David E, COUCH, Fergus J, SINGH, Namit, THOMPSON, James, ERDING, Catherine A, ENGEL, Christoph, SCHMUTZLER, Rita, DOMCHEK, Susan, NATHANSON, Katherine, RADICE, Paolo

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Pancreatic cancer as a sentinel for hereditary cancer predisposition von Young, Erin L, Thompson, Bryony A, Neklason, Deborah W, Firpo, Matthew A, Werner, Theresa, Bell, Russell, Berger, Justin, Fraser, Alison, Gammon, Amanda, Koptiuch, Cathryn, Kohlmann, Wendy K, Neumayer, Leigh, Goldgar, David E, Mulvihill, Sean J, Cannon-Albright, Lisa A, Tavtigian, Sean V

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Integrated Evaluation of DNA Sequence Variants of Unknown Clinical Significance: Application to BRCA1 and BRCA2 von Goldgar, David E., Easton, Douglas F., Deffenbaugh, Amie M., Monteiro, Alvaro N.A., Tavtigian, Sean V., Couch, Fergus J.

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Functional Assessment of Genetic Variants with Outcomes Adapted to Clinical Decision-Making von Thouvenot, Pierre, Ben Yamin, Barbara, Fourrière, Lou, Lescure, Aurianne, Boudier, Thomas, Del Nery, Elaine, Chauchereau, Anne, Goldgar, David E, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Nicolas, Alain, Millot, Gaël A

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Multiple Loci within the major histocompatibility complex confer risk of psoriasis von Feng, Bing-Jian, Sun, Liang-Dan, Soltani-Arabshahi, Razieh, Bowcock, Anne M, Nair, Rajan P, Stuart, Philip, Elder, James T, Schrodi, Steven J, Begovich, Ann B, Abecasis, Gonçalo R, Zhang, Xue-Jun, Callis-Duffin, Kristina P, Krueger, Gerald G, Goldgar, David E

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An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMB... von Chenevix-Trench, Georgia, Milne, Roger L, Antoniou, Antonis C, Couch, Fergus J, Easton, Douglas F, Goldgar, David E

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Effect of Chest X-Rays on the Risk of Breast Cancer Among BRCA1/2 Mutation Carriers in the International BRCA1/2 Carrier Cohort Study: A Report from the EMBRACE, GENEPSO, GEO-HEBON... von Andrieu, Nadine, Easton, Douglas F, Chang-Claude, Jenny, Rookus, Matti A, Brohet, Richard, Cardis, Elisabeth, Antoniou, Antonis C, Wagner, Teresa, Simard, Jacques, Evans, Gareth, Peock, Susan, Fricker, Jean-Pierre, Nogues, Catherine, Van't Veer, Laura, Van Leeuwen, Flora E, Goldgar, David E

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