Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia von Agoro, Rafiou, Montagna, Anna, Goetz, Regina, Aligbe, Onyedikachi, Singh, Gurinder, Coe, Lindsay M., Mohammadi, Moosa, Rivella, Stefano, Sitara, Despina

Volltext

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1 von Gattineni, Jyothsna, Bates, Carlton, Twombley, Katherine, Dwarakanath, Vangipuram, Robinson, Michael L, Goetz, Regina, Mohammadi, Moosa, Baum, Michel

Volltext

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway von Andrukhova, Olena, Zeitz, Ute, Goetz, Regina, Mohammadi, Moosa, Lanske, Beate, Erben, Reinhold G

Volltext

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ von Wei, Wei, Dutchak, Paul A, Wang, Xunde, Ding, Xunshan, Wang, Xueqian, Bookout, Angie L, Goetz, Regina, Mohammadi, Moosa, Gerard, Robert D, Dechow, Paul C, Mangelsdorf, David J, Kliewer, Steven A, Wan, Yihong

Volltext

LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake von Zhou, Zheng, Zhen, Juan, Karpowich, Nathan K, Goetz, Regina M, Law, Christopher J, Reith, Maarten E.A, Wang, Da-Neng

Volltext

The parathyroid is a target organ for FGF23 in rats von Ben-Dov, Iddo Z, Galitzer, Hillel, Lavi-Moshayoff, Vardit, Goetz, Regina, Kuro-o, Makoto, Mohammadi, Moosa, Sirkis, Roy, Naveh-Many, Tally, Silver, Justin

Volltext

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21 von Inagaki, Takeshi, Lin, Vicky Y., Goetz, Regina, Mohammadi, Moosa, Mangelsdorf, David J., Kliewer, Steven A.

Volltext

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response von Potthoff, Matthew J, Inagaki, Takeshi, Satapati, Santhosh, Ding, Xunshan, He, Tianteng, Goetz, Regina, Mohammadi, Moosa, Finck, Brian N, Mangelsdorf, David J, Kliewer, Steven A, Burgess, Shawn C

Volltext

Exploring mechanisms of FGF signalling through the lens of structural biology von Goetz, Regina, Mohammadi, Moosa

Volltext

Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion von Olauson, Hannes, Lindberg, Karolina, Amin, Risul, Sato, Tadatoshi, Jia, Ting, Goetz, Regina, Mohammadi, Moosa, Andersson, Göran, Lanske, Beate, Larsson, Tobias E

Volltext

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer von Suh, Jae Myoung, Jonker, Johan W., Ahmadian, Maryam, Goetz, Regina, Lackey, Denise, Osborn, Olivia, Huang, Zhifeng, Liu, Weilin, Yoshihara, Eiji, van Dijk, Theo H., Havinga, Rick, Fan, Weiwei, Yin, Yun-Qiang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Olefsky, Jerrold M., Mohammadi, Moosa, Downes, Michael, Evans, Ronald M.

Volltext

Isolated C-Terminal Tail of FGF23 Alleviates Hypophosphatemia by Inhibiting FGF23-FGFR-Klotho Complex Formation von Goetz, Regina, Nakada, Yuji, Hu, Ming Chang, Kurosu, Hiroshi, Wang, Lei, Nakatani, Teruyo, Shi, Mingjun, Eliseenkova, Anna V., Razzaque, Mohammed S., Moe, Orson W., Kuro-o, Makoto, Mohammadi, Moosa, Potts, John T.

Volltext

βKlotho is required for metabolic activity of fibroblast growth factor 21 von Ogawa, Yasushi, Kurosu, Hiroshi, Yamamoto, Masaya, Nandi, Animesh, Rosenblatt, Kevin P, Goetz, Regina, Eliseenkova, Anna V, Mohammadi, Moosa, Kuro-o, Makoto

Volltext

Arterial klotho expression and FGF23 effects on vascular calcification and function von Lindberg, Karolina, Olauson, Hannes, Amin, Risul, Ponnusamy, Arvind, Goetz, Regina, Taylor, Rebecca F, Mohammadi, Moosa, Canfield, Ann, Kublickiene, Karolina, Larsson, Tobias E

Volltext

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members von Goetz, Regina, Beenken, Andrew, Ibrahimi, Omar A., Kalinina, Juliya, Olsen, Shaun K., Eliseenkova, Anna V., Xu, ChongFeng, Neubert, Thomas A., Zhang, Fuming, Linhardt, Robert J., Yu, Xijie, White, Kenneth E., Inagaki, Takeshi, Kliewer, Steven A., Yamamoto, Masaya, Kurosu, Hiroshi, Ogawa, Yasushi, Kuro-o, Makoto, Lanske, Beate, Razzaque, Mohammed S., Mohammadi, Moosa

Volltext

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice von Wang, Hongwei, Venkatesh, Madhukumar, Li, Hao, Goetz, Regina, Mukherjee, Subhajit, Biswas, Arunima, Zhu, Liang, Kaubisch, Andreas, Wang, Lei, Pullman, James, Whitney, Kathleen, Kuro-o, Makoto, Roig, Andres I, Shay, Jerry W, Mohammadi, Moosa, Mani, Sridhar

Volltext

Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels von Goetz, Regina, Dover, Katarzyna, Laezza, Fernanda, Shtraizent, Nataly, Huang, Xiao, Tchetchik, Dafna, Eliseenkova, Anna V., Xu, Chong-Feng, Neubert, Thomas A., Ornitz, David M., Goldfarb, Mitchell, Mohammadi, Moosa

Volltext

Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands von Goetz, Regina, Ohnishi, Mutsuko, Ding, Xunshan, Kurosu, Hiroshi, Wang, Lei, Akiyoshi, Junko, Ma, Jinghong, Gai, Weiming, Sidis, Yisrael, Pitteloud, Nelly, Kuro-o, Makoto, Razzaque, Mohammed S., Mohammadi, Moosa

Volltext

A protein canyon in the FGF–FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs von Mohammadi, Moosa, Olsen, Shaun K, Goetz, Regina

Volltext

FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis von Medici, Damian, Razzaque, Mohammed S, DeLuca, Stephelynn, Rector, Trent L, Hou, Bo, Kang, Kihwa, Goetz, Regina, Mohammadi, Moosa, Kuro-o, Makoto, Olsen, Bjorn R, Lanske, Beate

Volltext