ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation von Goess, Christian, Harris, Christopher M., Murdock, Sara, McCarthy, Richard W., Sampson, Erik, Twomey, Rachel, Mathieu, Suzanne, Mario, Regina, Perham, Matthew, Goedken, Eric R., Long, Andrew J.

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Analysis of the role of PCNA-DNA contacts during clamp loading von McNally, Randall, Bowman, Gregory D, Goedken, Eric R, O'Donnell, Mike, Kuriyan, John

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ACT1 Is Required for Murine IL-23–Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity von Lipovsky, Alex, Slivka, Peter F., Su, Zhi, Wang, Yibing, Paulsboe, Stephanie, Wetter, Joseph, Namovic, Marian T., Gauvin, Donna, Perron, Denise, Gauld, Stephen B., McGaraughty, Steven, Goedken, Eric R.

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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds von Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.

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Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis von Su, Zhi, Slivka, Peter, Paulsboe, Stephanie, Chu, Katherine, Wetter, Joseph B, Namovic, Marian, Perron, Denise, Kannan, Arun, Wan, Qi, Manning, Charlene, Todorovic, Viktor, Smith, Kathleen M, Lipovsky, Alex, Wang, Yibing, Frank, Kristine, McGaraughty, Steve, Loud, Jacqueline, Scott, Victoria E, Honore, Prisca, Goedken, Eric R

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The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex von Simonetta, Kyle R., Kazmirski, Steven L., Goedken, Eric R., Cantor, Aaron J., Kelch, Brian A., McNally, Randall, Seyedin, Steven N., Makino, Debora L., O'Donnell, Mike, Kuriyan, John

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Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses von Slivka, Peter F, Hsieh, Chen-Lin, Lipovsky, Alex, Pratt, Steven D, Locklear, John, Namovic, Marian T, McDonald, Heath A, Wetter, Joseph, Edelmayer, Rebecca, Hu, Min, Murphy, Erin, Domanus, Marc, Lu, Charles, Duggan, Ryan, King, Jacob, Scott, Victoria E, Donnelly-Roberts, Diana, Slavin, Anthony, Gopalakrishnan, Sujatha, Chung, Namjin, Goedken, Eric R

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Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase von Harris, Christopher M., Foley, Sage E., Goedken, Eric R., Michalak, Mark, Murdock, Sara, Wilson, Noel S.

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Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis von Liu, Hongcheng, Chumsae, Chris, Gaza-Bulseco, Georgeen, Goedken, Eric R.

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Co-crystal of Escherichia coli RNase HI with Mn2+ Ions Reveals Two Divalent Metals Bound in the Active Site von Goedken, Eric R., Marqusee, Susan

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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor von Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V

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Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage von Goedken, Eric R., O’Brien, Robert F., Xiang, Tao, Banach, David L., Marchie, Susan C., Barlow, Eve H., Hubbard, Stacy, Mankovich, John A., Jiang, Jianjun, Richardson, Paul L., Cuff, Carolyn A., Cherniack, Andrew D.

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Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium von Argiriadi, Maria A, Goedken, Eric R, Bruck, Irina, O'Donnell, Mike, Kuriyan, John

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Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding von Goedken, Eric R, Levitus, Marcia, Johnson, Aaron, Bustamante, Carlos, O'Donnell, Mike, Kuriyan, John

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Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension von Goedken, Eric R., Marqusee, Susan

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Importance of the C-Terminal Helix to the Stability and Enzymatic Activity of Escherichia coli Ribonuclease H von Goedken, Eric R, Raschke, Tanya M, Marqusee, Susan

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Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition von Keck, J L, Goedken, E R, Marqusee, S

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The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds von Toth, E A, Worby, C, Dixon, J E, Goedken, E R, Marqusee, S, Yeates, T O

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Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding von Goedken, Eric R., Levitus, Marcia, Johnson, Aaron, Bustamante, Carlos, O'Donnell, Mike, Kuriyan, John

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Native-state energetics of a thermostabilized variant of ribonuclease HI von Goedken, E R, Marqusee, S

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