BRAF Inhibition in Refractory Hairy-Cell Leukemia von Dietrich, Sascha, Glimm, Hanno, Andrulis, Mindaugas, von Kalle, Christof, Ho, Anthony D, Zenz, Thorsten

Volltext

The landscape of chromothripsis across adult cancer types von Voronina, Natalia, Wong, John K. L., Hübschmann, Daniel, Hlevnjak, Mario, Uhrig, Sebastian, Heilig, Christoph E., Horak, Peter, Kreutzfeldt, Simon, Mock, Andreas, Stenzinger, Albrecht, Hutter, Barbara, Fröhlich, Martina, Brors, Benedikt, Jahn, Arne, Klink, Barbara, Gieldon, Laura, Sieverling, Lina, Feuerbach, Lars, Chudasama, Priya, Beck, Katja, Kroiss, Matthias, Heining, Christoph, Möhrmann, Lino, Fischer, Andrea, Schröck, Evelin, Glimm, Hanno, Zapatka, Marc, Lichter, Peter, Fröhling, Stefan, Ernst, Aurélie

Volltext

Sarcoma classification by DNA methylation profiling von Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail, Fernández-Klett, Francisco, Casalini, Belén, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Pérez, Laura, Grünewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Debus, Jürgen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Jürgen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Griewank, Klaus, de Álava, Enrique, Martín, Juan Díaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Büttner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjær, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Jones, David T. W., Fröhling, Stefan, von Deimling, Andreas

Volltext

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking von Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M, Northcott, Paul A, Petersen, Iver, Pfister, Stefan M, Schneider, Martin, Solberg, Steinar K, Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R, Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O

Volltext

Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real‐life analysis of three larger gene panels von Endris, Volker, Buchhalter, Ivo, Allgäuer, Michael, Rempel, Eugen, Lier, Amelie, Volckmar, Anna‐Lena, Kirchner, Martina, Winterfeld, Moritz, Leichsenring, Jonas, Neumann, Olaf, Penzel, Roland, Weichert, Wilko, Glimm, Hanno, Fröhling, Stefan, Winter, Hauke, Herth, Felix, Thomas, Michael, Schirmacher, Peter, Budczies, Jan, Stenzinger, Albrecht

Volltext

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells von Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer, Boutros, Michael

Volltext

A largely random AAV integration profile after LPLD gene therapy von Kaeppel, Christine, Beattie, Stuart G, Fronza, Raffaele, van Logtenstein, Richard, Salmon, Florence, Schmidt, Sabine, Wolf, Stephan, Nowrouzi, Ali, Glimm, Hanno, von Kalle, Christof, Petry, Harald, Gaudet, Daniel, Schmidt, Manfred

Volltext

Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study von Stenzinger, Albrecht, Endris, Volker, Budczies, Jan, Merkelbach-Bruse, Sabine, Kazdal, Daniel, Dietmaier, Wolfgang, Pfarr, Nicole, Siebolts, Udo, Hummel, Michael, Herold, Sylvia, Andreas, Johanna, Zoche, Martin, Tögel, Lars, Rempel, Eugen, Maas, Jörg, Merino, Diana, Stewart, Mark, Zaoui, Karim, Schlesner, Matthias, Glimm, Hanno, Fröhling, Stefan, Allen, Jeff, Horst, David, Baretton, Gustavo, Wickenhauser, Claudia, Tiemann, Markus, Evert, Matthias, Moch, Holger, Kirchner, Thomas, Büttner, Reinhard, Schirmacher, Peter, Jung, Andreas, Haller, Florian, Weichert, Wilko, Dietel, Manfred

Volltext

TelomereHunter - in silico estimation of telomere content and composition from cancer genomes von Feuerbach, Lars, Sieverling, Lina, Deeg, Katharina I, Ginsbach, Philip, Hutter, Barbara, Buchhalter, Ivo, Northcott, Paul A, Mughal, Sadaf S, Chudasama, Priya, Glimm, Hanno, Scholl, Claudia, Lichter, Peter, Fröhling, Stefan, Pfister, Stefan M, Jones, David T W, Rippe, Karsten, Brors, Benedikt

Volltext

High-resolution insertion-site analysis by linear amplification–mediated PCR (LAM-PCR) von Schmidt, Manfred, Schwarzwaelder, Kerstin, Bartholomae, Cynthia, Zaoui, Karim, Ball, Claudia, Pilz, Ingo, Braun, Sandra, Glimm, Hanno, von Kalle, Christof

Volltext

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases von Dieter, Sebastian M., Ball, Claudia R., Hoffmann, Christopher M., Nowrouzi, Ali, Herbst, Friederike, Zavidij, Oksana, Abel, Ulrich, Arens, Anne, Weichert, Wilko, Brand, Karsten, Koch, Moritz, Weitz, Jürgen, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

Volltext

YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis von Thomann, Stefan, Weiler, Sofia M E, Marquard, Simone, Rose, Fabian, Ball, Claudia R, Tóth, Marcell, Wei, Teng, Sticht, Carsten, Fritzsche, Sarah, Roessler, Stephanie, De La Torre, Carolina, Ryschich, Eduard, Ermakova, Olga, Mogler, Carolin, Kazdal, Daniel, Gretz, Norbert, Glimm, Hanno, Rempel, Eugen, Schirmacher, Peter, Breuhahn, Kai

Volltext

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma von Gröschel, Stefan, Hübschmann, Daniel, Raimondi, Francesco, Horak, Peter, Warsow, Gregor, Fröhlich, Martina, Klink, Barbara, Gieldon, Laura, Hutter, Barbara, Kleinheinz, Kortine, Bonekamp, David, Marschal, Oliver, Chudasama, Priya, Mika, Jagoda, Groth, Marie, Uhrig, Sebastian, Krämer, Stephen, Heining, Christoph, Heilig, Christoph E., Richter, Daniela, Reisinger, Eva, Pfütze, Katrin, Eils, Roland, Wolf, Stephan, von Kalle, Christof, Brandts, Christian, Scholl, Claudia, Weichert, Wilko, Richter, Stephan, Bauer, Sebastian, Penzel, Roland, Schröck, Evelin, Stenzinger, Albrecht, Schlenk, Richard F., Brors, Benedikt, Russell, Robert B., Glimm, Hanno, Schlesner, Matthias, Fröhling, Stefan

Volltext

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung von Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

Volltext

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis von Bormann, Felix, Rodríguez-Paredes, Manuel, Lasitschka, Felix, Edelmann, Dominic, Musch, Tanja, Benner, Axel, Bergman, Yehudit, Dieter, Sebastian M., Ball, Claudia R., Glimm, Hanno, Linhart, Heinz G., Lyko, Frank

Volltext

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model von Klose, Johannes, Trefz, Stefan, Wagner, Tobias, Steffen, Luca, Preißendörfer Charrier, Arsalie, Radhakrishnan, Praveen, Volz, Claudia, Schmidt, Thomas, Ulrich, Alexis, Dieter, Sebastian M, Ball, Claudia, Glimm, Hanno, Schneider, Martin

Volltext

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains von Weinberg, Florian, Griffin, Ricarda, Fröhlich, Martina, Heining, Christoph, Braun, Sandra, Spohr, Corinna, Iconomou, Mary, Hollek, Viola, Röring, Michael, Horak, Peter, Kreutzfeldt, Simon, Warsow, Gregor, Hutter, Barbara, Uhrig, Sebastian, Neumann, Olaf, Reuss, David, Heiland, Dieter Henrik, von Kalle, Christof, Weichert, Wilko, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Fröhling, Stefan, Brummer, Tilman

Volltext

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo von Weber, Sarah, Koschade, Sebastian E, Hoffmann, Christopher M, Dubash, Taronish D, Giessler, Klara M, Dieter, Sebastian M, Herbst, Friederike, Glimm, Hanno, Ball, Claudia R

Volltext

The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision von Herbst, Friederike, Lang, Tonio J. L., Eckert, Elias S. P., Wünsche, Peer, Wurm, Alexander A., Kindinger, Tim, Laaber, Karin, Hemmati, Shayda, Hotz-Wagenblatt, Agnes, Zavidij, Oksana, Paruzynski, Anna, Lu, Junyan, von Kalle, Christof, Zenz, Thorsten, Klein, Christoph, Schmidt, Manfred, Ball, Claudia R., Glimm, Hanno

Volltext

Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold von Schmäche, Tim, Fohgrub, Juliane, Klimova, Anna, Laaber, Karin, Drukewitz, Stephan, Merboth, Felix, Hennig, Alexander, Seidlitz, Therese, Herbst, Friederike, Baenke, Franziska, Ada, Anne-Marlen, Groß, Thomas, Wenzel, Carina, Ball, Claudia R, Praetorius, Christian, Schmidt, Thomas, Ringelband-Schilling, Barbara, Koschny, Ronald, Stenzinger, Albrecht, Roeder, Ingo, Jaeger, Dirk, Zeissig, Sebastian, Welsch, Thilo, Aust, Daniela, Glimm, Hanno, Folprecht, Gunnar, Weitz, Jürgen, Haag, Georg M, Stange, Daniel E

Volltext