Enzymatic Kinetic Resolution of Piperidine Atropisomers:  Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336 von Morgan, Brian, Zaks, Aleksey, Dodds, David R, Liu, Jinchu, Jain, Rama, Megati, Sreeni, Njoroge, F. George, Girijavallabhan, Viyyoor M

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New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents von Zhu, Hugh Y, Desai, Jagdish, Cooper, Alan B, Wang, James, Rane, Dinananth F, Kirschmeier, Paul, Strickland, Corey, Liu, Ming, Nomeir, Amin A, Girijavallabhan, Viyyoor M

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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor von Bennett, Frank, Huang, Yuhua, Hendrata, Siska, Lovey, Raymond, Bogen, Stephane L., Pan, Weidong, Guo, Zhuyan, Prongay, Andrew, Chen, Kevin X., Arasappan, Ashok, Venkatraman, Srikanth, Velazquez, Francisco, Nair, Latha, Sannigrahi, Mousumi, Tong, Xiao, Pichardo, John, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor M., Saksena, Anil K., Njoroge, F. George

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice von MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

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Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design von Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M, Madison, Vincent S, Yao, Nanua H, Prongay, Andrew J, Butkiewicz, Nancy, Pichardo, John

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Discovery of C-imidazole azaheptapyridine FPT inhibitors von Zhu, Hugh Y., Cooper, Alan B., Desai, Jagdish, Njoroge, George, Kirschmeier, Paul, Bishop, W. Robert, Strickland, Corey, Hruza, Alan, Doll, Ronald J., Girijavallabhan, Viyyoor M.

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Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51... von Saksena, Anil K, Girijavallabhan, Viyyoor M, Wang, Haiyan, Liu, Yi-Tsung, Pike, Russel E, Ganguly, Ashit K

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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5] von Bennett, Frank, Saksena, Anil K., Lovey, Raymond G., Liu, Yi-Tsung, Patel, Naginbhai M., Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M., Ganguly, Ashit K., Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S., Nomeir, Amin

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Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes von Mirza, Urooj A, Chen, Guodong, Liu, Yan-Hui, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Pramanik, Birendra N

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Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships von Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Fa... von Njoroge, F. George, Taveras, Arthur G, Kelly, Joseph, Remiszewski, Stacy, Mallams, Alan K, Wolin, Ronald, Afonso, Adriano, Cooper, Alan B, Rane, Dinananth F, Liu, Yi-Tsung, Wong, Jesse, Vibulbhan, Bancha, Pinto, Patrick, Deskus, Jeffrey, Alvarez, Carmen S, del Rosario, Joycelyn, Connolly, Michael, Wang, James, Desai, Jagdish, Rossman, Randall R, Bishop, W. Robert, Patton, Robert, Wang, Lynn, Kirschmeier, Paul, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, McPhail, Andrew T, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

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Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A von Jao, Edwin, Cooper, Alan B, Rane, Dinanath F, Saksena, Anil K, Desai, Jagdish, Wang, James, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

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Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR von Saksena, Anil K., Girijavallabhan, Viyyoor M., Wang, Haiyan, Lovey, Raymond G., Guenter, Frank, Mergelsberg, Ingrid, Puar, Mohinder S.

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein von Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E

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Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048 von Lovey, Raymond G, Saksena, Anil K, Girijavallabhan, Viyyoor M, Blundell, Paul, Guzik, Henry, Loebenberg, David, Parmegiani, Raulo M, Cacciapuoti, Anthony

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Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities von Taveras, Arthur G, Deskus, Jeff, Chao, Jianping, Vaccaro, Cynthia J, Njoroge, F. George, Vibulbhan, Bancha, Pinto, Pat, Remiszewski, Stacy, del Rosario, Jocelyn, Doll, Ronald J, Alvarez, Carmen, Lalwani, Tarik, Mallams, Alan K, Rossman, Randall R, Afonso, Adriano, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Pramanik, Birendra, Heimark, Larry, Bishop, W. Robert, Wang, Lynn, Kirschmeier, Paul, James, Linda, Carr, Donna, Patton, Robert, Bryant, Mathew S, Nomeir, Amin A, Liu, Ming

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Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine... von Mallams, Alan K, Rossman, Randall R, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Petrin, Joanne, Wang, Lynn, Patton, Robert, Bishop, W. Robert, Carr, Donna M, Kirschmeier, Paul, Catino, Joseph J, Bryant, Matthew S, Chen, Kwang-Jong, Korfmacher, Walter A, Nardo, Cymbelene, Wang, Shiyong, Nomeir, Amin A, Lin, Chin-Chung, Li, Zujun, Chen, Jianping, Lee, Suining, Dell, Janet, Lipari, Philip, Malkowski, Michael, Yaremko, Bodan, King, Ivan, Liu, Ming

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Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation von Blundell, Paul, Ganguly, Ashit K., Girijavallabhan, Viyyoor M.

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Negative ion multiple-stage mass spectrometric analysis of complex oligosaccharides (everninomicins) in a quadruple ion trap: implications for charge-remote fragmentation von Ganguly, A. K., Chen, Guodong, Pramanik, Birendra N., Daaro, Ibrahim, Luk, Emily, Bartner, Peter L., Saksena, Anil K., Girijavallabhan, Viyyoor M.

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An Enantioselective Synthesis of the Antifungal Agent (2R, 3R)-2-(2,4-Difluorophenyl)-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-butanol (Sch 42427; SM 9164) von Bennett, Frank, Ganguly, Ashit K., Girijavallabhan, Viyyoor M., Pinto, Patrick A.

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