Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0... von Venkatraman, Srikanth, Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond, Hendrata, Siska, Huang, Yuhua, Pan, Weidong, Parekh, Tejal, Pinto, Patrick, Popov, Veljko, Pike, Russel, Ruan, Sumei, Santhanam, Bama, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Kong, Jianshe, Liang, Xiang, Wong, Jesse, Liu, Rong, Butkiewicz, Nancy, Chase, Robert, Hart, Andrea, Agrawal, Sony, Ingravallo, Paul, Pichardo, John, Kong, Rong, Baroudy, Bahige, Malcolm, Bruce, Guo, Zhuyan, Prongay, Andrew, Madison, Vincent, Broske, Lisa, Cui, Xiaoming, Cheng, Kuo-Chi, Hsieh, Yunsheng, Brisson, Jean-Marc, Prelusky, Danial, Korfmacher, Walter, White, Ronald, Bogdanowich-Knipp, Susan, Pavlovsky, Anastasia, Bradley, Prudence, Saksena, Anil K, Ganguly, Ashit, Piwinski, John, Girijavallabhan, Viyyoor, Njoroge, F. George

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New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents von Zhu, Hugh Y, Desai, Jagdish, Cooper, Alan B, Wang, James, Rane, Dinananth F, Kirschmeier, Paul, Strickland, Corey, Liu, Ming, Nomeir, Amin A, Girijavallabhan, Viyyoor M

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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1... von Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor von Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George

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Potent inhibitors of HCV-NS3 protease derived from boronic acids von Venkatraman, Srikanth, Wu, Wanli, Prongay, Andrew, Girijavallabhan, Viyyoor, George Njoroge, F.

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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor von Bennett, Frank, Huang, Yuhua, Hendrata, Siska, Lovey, Raymond, Bogen, Stephane L., Pan, Weidong, Guo, Zhuyan, Prongay, Andrew, Chen, Kevin X., Arasappan, Ashok, Venkatraman, Srikanth, Velazquez, Francisco, Nair, Latha, Sannigrahi, Mousumi, Tong, Xiao, Pichardo, John, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor M., Saksena, Anil K., Njoroge, F. George

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice von MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

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Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design von Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M, Madison, Vincent S, Yao, Nanua H, Prongay, Andrew J, Butkiewicz, Nancy, Pichardo, John

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Discovery of C-imidazole azaheptapyridine FPT inhibitors von Zhu, Hugh Y., Cooper, Alan B., Desai, Jagdish, Njoroge, George, Kirschmeier, Paul, Bishop, W. Robert, Strickland, Corey, Hruza, Alan, Doll, Ronald J., Girijavallabhan, Viyyoor M.

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Enzymatic Kinetic Resolution of Piperidine Atropisomers:  Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336 von Morgan, Brian, Zaks, Aleksey, Dodds, David R, Liu, Jinchu, Jain, Rama, Megati, Sreeni, Njoroge, F. George, Girijavallabhan, Viyyoor M

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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5] von Bennett, Frank, Saksena, Anil K., Lovey, Raymond G., Liu, Yi-Tsung, Patel, Naginbhai M., Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M., Ganguly, Ashit K., Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S., Nomeir, Amin

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Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes von Mirza, Urooj A, Chen, Guodong, Liu, Yan-Hui, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Pramanik, Birendra N

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Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships von Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Fa... von Njoroge, F. George, Taveras, Arthur G, Kelly, Joseph, Remiszewski, Stacy, Mallams, Alan K, Wolin, Ronald, Afonso, Adriano, Cooper, Alan B, Rane, Dinananth F, Liu, Yi-Tsung, Wong, Jesse, Vibulbhan, Bancha, Pinto, Patrick, Deskus, Jeffrey, Alvarez, Carmen S, del Rosario, Joycelyn, Connolly, Michael, Wang, James, Desai, Jagdish, Rossman, Randall R, Bishop, W. Robert, Patton, Robert, Wang, Lynn, Kirschmeier, Paul, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, McPhail, Andrew T, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

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A Convenient Synthesis of Cis and Trans 4-tert-Butoxycarbonyl-Substituted Cyclohexylglycine von Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor, McPhail, Andrew T

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Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51... von Saksena, Anil K, Girijavallabhan, Viyyoor M, Wang, Haiyan, Liu, Yi-Tsung, Pike, Russel E, Ganguly, Ashit K

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein von Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E

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Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048 von Lovey, Raymond G, Saksena, Anil K, Girijavallabhan, Viyyoor M, Blundell, Paul, Guzik, Henry, Loebenberg, David, Parmegiani, Raulo M, Cacciapuoti, Anthony

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Discovery and Structure−Activity Relationship of P 1 −P 3 Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease von Venkatraman, Srikanth, Velazquez, Francisco, Wu, Wanli, Blackman, Melissa, Chen, Kevin X., Bogen, Stephane, Nair, Latha, Tong, Xiao, Chase, Robert, Hart, Andrea, Agrawal, Sony, Pichardo, John, Prongay, Andrew, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor, Piwinski, John, Shih, Neng-Yang, Njoroge, F. George

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Application of Ring-Closing Metathesis for the Synthesis of Macrocyclic Peptidomimetics as Inhibitors of HCV NS3 Protease von Velázquez, Francisco, Venkatraman, Srikanth, Wu, Wanli, Blackman, Melissa, Prongay, Andrew, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Njoroge, F. George

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