Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis von Papp, Kim, Gordon, Kenneth, Thaçi, Diamant, Morita, Akimichi, Gooderham, Melinda, Foley, Peter, Girgis, Ihab G, Kundu, Sudeep, Banerjee, Subhashis

Volltext

Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559) von Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

Volltext

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab von Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

Volltext

First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2 von Catlett, Ian M., Aras, Urvi, Hansen, Lars, Liu, Yali, Bei, Di, Girgis, Ihab G., Murthy, Bindu

Volltext

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors von Chimalakonda, Anjaneya, Burke, James, Cheng, Lihong, Catlett, Ian, Tagen, Michael, Zhao, Qihong, Patel, Aditya, Shen, Jun, Girgis, Ihab G., Banerjee, Subhashis, Throup, John

Volltext

Safety, pharmacokinetics and pharmacodynamics of branebrutinib (BMS‐986195), a covalent, irreversible inhibitor of Bruton's tyrosine kinase: Randomised phase I, placebo‐controlled... von Catlett, Ian M., Nowak, Miroslawa, Kundu, Sudeep, Zheng, Naiyu, Liu, Ang, He, Bing, Girgis, Ihab G., Grasela, Dennis M.

Volltext

Pharmacokinetics and Safety of the Tyrosine Kinase 2 Inhibitor Deucravacitinib in Healthy Chinese Subjects von Jing, Shan, Lin, Yang, Dockens, Randy, Marchisin, David, He, Bing, Girgis, Ihab G., Chimalakonda, Anjaneya, Murthy, Bindu, Aras, Urvi

Volltext

Lack of Electrocardiographic Effects of Deucravacitinib in Healthy Subjects von Chimalakonda, Anjaneya, Singhal, Shalabh, Darbenzio, Raymond, Dockens, Randy, Marchisin, David, Banerjee, Subhashis, Girgis, Ihab G., Throup, John, He, Bing, Aras, Urvi, Murthy, Bindu

Volltext

Pharmacokinetic–pharmacodynamic assessment of topiramate dosing regimens for children with epilepsy 2 to <10 years of age von Girgis, Ihab G., Nandy, Partha, Nye, Jeffrey S., Ford, Lisa, Mohanty, Surya, Wang, Steven, Ochalski, Stefan, Eerdekens, Marielle, Cox, Eugène

Volltext

Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart R... von Bihorel, Sébastien, Singhal, Shalabh, Shevell, Diane, Sun, Huadong, Xie, Jenny, Basdeo, Shenita, Liu, Ang, Dutta, Santanu, Ludwig, Elizabeth, Huang, Hannah, Lin, Kuan‐ju, Fura, Aberra, Throup, John, Girgis, Ihab G.

Volltext

Population Pharmacodynamic Parameter Estimation from Sparse Sampling: Effect of Sigmoidicity on Parameter Estimates von Pai, Sudhakar M., Girgis, Suzette, Batra, Vijay K., Girgis, Ihab G.

Volltext

Pharmacodynamic parameter estimation: population size versus number of samples von Girgis, Suzette, Pai, Sudhakar M, Girgis, Ihab G, Batra, Vijay K

Volltext

Assessment of Antitachycardia Pacing in Primary Prevention Patients: The APPRAISE ATP Randomized Clinical Trial von Schuger, Claudio, Joung, Boyoung, Ando, Kenji, Mont, Lluís, Lambiase, Pier D, O’Hara, Gilles E, Jennings, John M, Yung, Derek, Boriani, Giuseppe, Piccini, Jonathan P, Wold, Nicholas, Stein, Kenneth M, Daubert, James P

Volltext

Immune checkpoint inhibition in sepsis: a Phase 1b randomized, placebo-controlled, single ascending dose study of anti-PD-L1 (BMS-936559) von Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

Volltext

Selective Inhibition of Tyrosine Kinase 2 With Deucravacitinib (BMS-986165) Compared With Janus Kinase 1−3 Inhibitors von Chimalakonda, Anjaneya, Burke, James, Cheng, Lihong, Catlett, Ian, Patel, Aditya, Shen, Jun, Girgis, Ihab, Banerjee, Subhashis, Throup, John

Volltext

Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants t... von Cai, Weiguo, Leil, Tarek A., Gibiansky, Leonid, Krishna, Murli, Zhang, Hongwei, Gu, Huidong, Sun, Huadong, Throup, John, Banerjee, Subhashis, Girgis, Ihab

Volltext

A Prospective Study of the Effect of IV Pentamidine Therapy on Ventricular Arrhythmias and QTc Prolongation in HIV-infected Patients von Girgis, Ihab, Gualberti, Joann, Langan, Lawrence, Malek, Sherif, Mustaciuolo, Vincent, Costantino, Thomas, McGinn, Thomas G.

Volltext

A comparison of in silico cardiac action potential simulations with electrophysiological effects in the isolated rabbit wedge preparation for compounds with different ion channel b... von Damiano, Bruce P., Rohrbacher, Jutta, Pugsley, Michael K., Girgis, Ihab, Lu, Hua Rong, Gallacher, David J.

Volltext

The source of hERG IC50 values (manual vs. automated patch clamp) may influence in silico modeling von Rohrbacher, Jutta, Damiano, Bruce P., Girgis, Ihab G., Pugsley, Michael K., Teisman, Ard, Gallacher, David J.

Volltext

Effects of Hemodialysis on Left Ventricular Diastolic Filling von Chakko, Simon, Girgis, Ihab, Contreras, Gabriel, Perez, Guido, Kessler, Kenneth M, Myerburg, Robert J

Volltext