Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney von Miner, Jeffrey N, Tan, Philip K, Hyndman, David, Liu, Sha, Iverson, Cory, Nanavati, Payal, Hagerty, David T, Manhard, Kimberly, Shen, Zancong, Girardet, Jean-Luc, Yeh, Li-Tain, Terkeltaub, Robert, Quart, Barry

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A Novel Nonnucleoside Analogue That Inhibits Human Immunodeficiency Virus Type 1 Isolates Resistant to Current Nonnucleoside Reverse Transcriptase Inhibitors von ZHIJUN ZHANG, WEN XU, KOH, Yung-Hyo, JAE HOON SHIM, GIRARDET, Jean-Luc, YEH, Li-Tain, HAMATAKE, Robert K, ZHI HONG

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Novel Nonnucleoside Inhibitors That Select Nucleoside Inhibitor Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase von ZHIJUN ZHANG, WALKER, Michelle, WEN XU, JAE HOON SHIM, GIRARDET, Jean-Luc, HAMATAKE, Robert K, ZHI HONG

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Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers von Yang, Chun, Zhou, Dongmei, Shen, Zancong, Wilson, David M, Renner, Matthew, Miner, Jeffrey N, Girardet, Jean-Luc, Lee, Caroline A

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Metabolism and Disposition of Verinurad, a Uric Acid Reabsorption Inhibitor, in Humans von Lee, Caroline A, Yang, Chun, Shah, Vishal, Shen, Zancong, Wilson, David M, Ostertag, Traci M, Girardet, Jean-Luc, Hall, Jesse, Gillen, Michael

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Synthesis of pyrrolo[2,3- d]pyrimidine nucleoside derivatives as potential anti-HCV agents von Varaprasad, Chamakura V.N.S., Ramasamy, Kanda S., Girardet, Jean-Luc, Gunic, Esmir, Lai, Vicky, Zhong, Weidong, An, Haoyun, Hong, Zhi

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Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′- C-bridged 2′-deoxynucleosides von Wang, Guangyi, Gunic, Esmir, Girardet, Jean-Luc, Stoisavljevic, Vesna

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Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase von De La Rosa, Martha, Kim, Hong Woo, Gunic, Esmir, Jenket, Cheryl, Boyle, Uyen, Koh, Yung-hyo, Korboukh, Ilia, Allan, Matthew, Zhang, Weijian, Chen, Huanming, Xu, Wen, Nilar, Shahul, Yao, Nanhua, Hamatake, Robert, Lang, Stanley A., Hong, Zhi, Zhang, Zhijun, Girardet, Jean-Luc

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Design, Synthesis, and Antiviral Activity of Adenosine 5‘-Phosphonate Analogues as Chain Terminators against Hepatitis C Virus von Koh, Yung-hyo, Shim, Jae Hoon, Wu, Jim Zhen, Zhong, Weidong, Hong, Zhi, Girardet, Jean-Luc

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Conformationally locked nucleosides. Synthesis and stereochemical assignments of 2′- C,4′- C-bridged bicyclonucleosides von Wang, Guangyi, Girardet, Jean-Luc, Gunic, Esmir

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Design, Synthesis, and Antiviral Activity of α-Nucleosides:  d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles von Migawa, Michael T., Girardet, Jean-Luc, Walker, John A., Koszalka, George W., Chamberlain, Stanley D., Drach, John C., Townsend, Leroy B.

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Cyclic monophosphate prodrugs of base-modified 2′- C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication von Gunic, Esmir, Girardet, Jean-Luc, Ramasamy, Kanda, Stoisavljevic-Petkov, Vesna, Chow, Suetying, Yeh, Li-Tain, Hamatake, Robert K., Raney, Anneke, Hong, Zhi

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Rational design for cytosolic delivery of nucleoside monphosphates : “SATE” and “DTE” as enzyme-labile transient phosphate protecting groups von Périgaud, Christian, Gosselin, Gilles, Lefebvre, Isabelle, Girardet, Jean-Luc, Benzaria, Samira, Barber, Isabelle, Imbach, Jean-Louis

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Synthesis and cytotoxicity of 4′- C- and 5′- C-substituted toyocamycins von Gunic, Esmir, Girardet, Jean-Luc, Pietrzkowski, Zbigniew, Esler, Cathey, Wang, Guangyi

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6-Hydrazinopurine 2′-methyl ribonucleosides and their 5′-monophosphate prodrugs as potent hepatitis C virus inhibitors von Gunic, Esmir, Chow, Suetying, Rong, Frank, Ramasamy, Kanda, Raney, Anneke, Yunzhi Li, David, Huang, Jingfan, Hamatake, Robert K., Hong, Zhi, Girardet, Jean-Luc

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Design and evaluation of a potential mutagen for Hepatitis C virus von Koh, Yung-Hyo, Shim, Jae Hoon, Girardet, Jean-Luc, Hong, Zhi

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Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase von Ding, Yili, Girardet, Jean-Luc, Smith, Kenneth L., Larson, Gary, Prigaro, Brett, Wu, Jim Z., Yao, Nanhua

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Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase von Ding, Yili, Girardet, Jean-Luc, Smith, Kenneth L., Larson, Gary, Prigaro, Brett, Lai, Vicky C.H., Zhong, Weidong, Wu, Jim Z.

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Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosp... von Lefebvre, Isabelle, Perigaud, Christian, Pompon, Alain, Aubertin, Anne-Marie, Girardet, Jean-Luc, Kirn, Andre, Gosselin, Gilles, Imbach, Jean-Louis

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Multinuclear NMR Study of Fluoroaluminate Complexes in Aqueous Solution von Martinez, Eric J, Girardet, Jean-Luc, Morat, Claude

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