Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury von Liu, Xiaoying, Khalafalla, Mahmoud, Chung, Chuhan, Gindin, Yevgeniy, Hubchak, Susan, LeCuyer, Brian, Kriegermeier, Alyssa, Zhang, Danny, Qiu, Wei, Ding, Xianzhong, Fang, Deyu, Green, Richard

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A chromatin structure‐based model accurately predicts DNA replication timing in human cells von Gindin, Yevgeniy, Valenzuela, Manuel S, Aladjem, Mirit I, Meltzer, Paul S, Bilke, Sven

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Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis von Sharpton, Suzanne R., Podlaha, Ondrej, Chuang, Jen-Chieh, Gindin, Yevgeniy, Myers, Robert P., Loomba, Rohit

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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers von Miller, Christopher A., Gindin, Yevgeniy, Lu, Charles, Griffith, Obi L, Griffith, Malachi, Shen, Dong, Hoog, Jeremy, Li, Tiandao, Larson, David E., Watson, Mark, Davies, Sherri R, Hunt, Kelly, Suman, Vera J., Snider, Jacqueline, Walsh, Thomas, Colditz, Graham A., DeSchryver, Katherine, Wilson, Richard K., Mardis, Elaine R., Ellis, Matthew J.

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Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis von Trauner, Michael, Gindin, Yevgeniy, Jiang, Zhaoshi, Chung, Chuhan, Subramanian, G. Mani, Myers, Robert P., Gulamhusein, Aliya, Kowdley, Kris V., Levy, Cynthia, Goodman, Zachary, Manns, Michael P., Muir, Andrew J., Bowlus, Christopher L.

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Targeted analysis of glycomics liquid chromatography/mass spectrometry data von Dreyfuss, Jonathan M., Jacobs, Christopher, Gindin, Yevgeniy, Benson, Gary, Staples, Gregory O., Zaia, Joseph

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Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes von Parker, Stephen C J, Gartner, Jared, Cardenas-Navia, Isabel, Wei, Xiaomu, Ozel Abaan, Hatice, Ajay, Subramanian S, Hansen, Nancy F, Song, Lingyun, Bhanot, Umesh K, Killian, J Keith, Gindin, Yevgeniy, Walker, Robert L, Meltzer, Paul S, Mullikin, James C, Furey, Terrence S, Crawford, Gregory E, Rosenberg, Steven A, Samuels, Yardena, Margulies, Elliott H

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A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation von Vujkovic, Marijana, Ramdas, Shweta, Lorenz, Kim M., Guo, Xiuqing, Darlay, Rebecca, Cordell, Heather J., He, Jing, Gindin, Yevgeniy, Chung, Chuhan, Myers, Robert P., Schneider, Carolin V., Park, Joseph, Lee, Kyung Min, Serper, Marina, Carr, Rotonya M., Kaplan, David E., Haas, Mary E., MacLean, Matthew T., Witschey, Walter R., Zhu, Xiang, Tcheandjieu, Catherine, Kember, Rachel L., Kranzler, Henry R., Verma, Anurag, Giri, Ayush, Klarin, Derek M., Sun, Yan V., Huang, Jie, Huffman, Jennifer E., Creasy, Kate Townsend, Hand, Nicholas J., Liu, Ching-Ti, Long, Michelle T., Yao, Jie, Budoff, Matthew, Tan, Jingyi, Li, Xiaohui, Lin, Henry J., Chen, Yii-Der Ida, Taylor, Kent D., Chang, Ruey-Kang, Krauss, Ronald M., Vilarinho, Silvia, Brancale, Joseph, Nielsen, Jonas B., Locke, Adam E., Jones, Marcus B., Verweij, Niek, Baras, Aris, Reddy, K. Rajender, Neuschwander-Tetri, Brent A., Schwimmer, Jeffrey B., Sanyal, Arun J., Chalasani, Naga, Ryan, Kathleen A., Mitchell, Braxton D., Gill, Dipender, Wells, Andrew D., Manduchi, Elisabetta, Saiman, Yedidya, Mahmud, Nadim, Miller, Donald R., Reaven, Peter D., Phillips, Lawrence S., Muralidhar, Sumitra, DuVall, Scott L., Lee, Jennifer S., Assimes, Themistocles L., Pyarajan, Saiju, Cho, Kelly, Edwards, Todd L., Damrauer, Scott M., Wilson, Peter W., Gaziano, J. Michael, O’Donnell, Christopher J., Khera, Amit V., Grant, Struan F. A., Brown, Christopher D., Tsao, Philip S., Saleheen, Danish, Lotta, Luca A., Bastarache, Lisa, Anstee, Quentin M., Daly, Ann K., Meigs, James B., Rotter, Jerome I., Lynch, Julie A., Rader, Daniel J., Voight, Benjamin F., Chang, Kyong-Mi

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The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology von ABAAN, Ogan D, POLLEY, Eric C, HOLBECK, Susan L, SIMON, Richard M, DOROSHOW, James H, POMMIER, Yves, MELTZER, Paul S, DAVIS, Sean R, ZHU, Yuelin J, BILKE, Sven, WALKER, Robert L, PINEDA, Marbin, GINDIN, Yevgeniy, YUAN JIANG, REINHOLD, William C

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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy von Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika

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DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodefic... von Gindin, Yevgeniy, Gaggar, Anuj, Lok, Anna S, Janssen, Harry L A, Ferrari, Carlo, Subramanian, G Mani, Jiang, Zhaoshi, Masur, Henry, Emmanuel, Benjamin, Poonia, Bhawna, Kottilil, Shyam

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FRI361 - Peripheral soluble protein, transcriptomic, and methylation biomarkers associated with HBsAg loss in patients with chronic hepatitis B von Wallin, Jeffrey, Chen, Diana, Li, Ruidong, Kim, Sam, Gindin, Yevgeniy, Suri, Vithika, Podlaha, Ondrej, Li, Li, Gaggar, Anuj

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Peripheral soluble protein, transcriptomic, and methylation biomarkers associated with HBsAg loss in patients with chronic hepatitis B von Wallin, Jeffrey, Chen, Diana, Li, Ruidong, Kim, Sam, Gindin, Yevgeniy, Suri, Vithika, Podlaha, Ondrej, Li, Li, Gaggar, Anuj

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Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer von Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, Olive, Kenneth P.

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O02 The JAK1-selective inhibitor filgotinib reverses the disease-associated transcriptional profile in the blood of patients with active rheumatoid arthritis von Taylor, Peter, Downie, Bryan, Zhuo, Luting, Gindin, Yevgeniy, Tarrant, Jacqueline, Galien, René, Liu, Jinfeng, Mirza, Amer M

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A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis von Gindin, Yevgeniy, Chung, Chuhan, Jiang, Zhaoshi, Zhou, Jing Zhu, Xu, Jun, Billin, Andrew N., Myers, Robert P., Goodman, Zachary, Landi, Abdolamir, Houghton, Michael, Green, Richard M., Levy, Cynthia, Kowdley, Kris V., Bowlus, Christopher L., Muir, Andrew J., Trauner, Michael

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Abstract 5150: What is in control of DNA replication timing von Gindin, Yevgeniy, Meltzer, Paul S., Bilke, Sven

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Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer von Wasko, Urszula N, Jiang, Jingjing, Dalton, Tanner C, Curiel-Garcia, Alvaro, Edwards, A Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A, Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A, Palermo, Carmine F, Hasselluhn, Marie C, Decker-Farrell, Amanda R, Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C, Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B, Clendenin, Cynthia, Sor, Rina, Vostrejs, William P, Hibshman, Priya S, Amparo, Amber M, Hennessey, Connor, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D, Herring, Laura E, Barker, Natalie K, Wang, Junning, Cleary, James M, Wolpin, Brian M, Chabot, John A, Kluger, Michael D, Manji, Gulam A, Tsai, Kenneth Y, Sekulic, Miroslav, Lagana, Stephen M, Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A M, Holderfield, Matthew, Wildes, David, Lowe, Scott W, Badgley, Michael A, Aguirre, Andrew J, Vonderheide, Robert H, Stanger, Ben Z, Baslan, Timour, Der, Channing J, Singh, Mallika, Olive, Kenneth P

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FRI170 - Hepatic transcriptomic analysis identifies a mast cell gene expression signature that correlates with fibrosis stage and is prognostic in patients with primary sclerosing... von Trauner, Michael, Gindin, Yevgeniy, Zhou, Jing Zhu, Xu, Jun, Billin, Andrew, Chung, Chuhan, Subramanian, Mani, Myers, Robert, Tanaka, Atsushi, Goodman, Zachary, Muir, Andrew, Thorburn, Douglas, Bowlus, Christopher, Levy, Cynthia, Kowdley, Kris V.

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FRI169 - Removal of fibrosis-related genes identifies a hepatic gene expression signature that identifies canonical signaling pathways and is correlated with clinical outcomes in p... von Trauner, Michael, Gindin, Yevgeniy, Zhou, Jing Zhu, Huss, Ryan, Chung, Chuhan, Subramanian, Mani, Myers, Robert, Goodman, Zachary, Muir, Andrew, Bowlus, Christopher, Montano-Loza, Aldo J, Trivedi, Palak, LEVY, Cynthia

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