Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes von Zhan, Xuanzhi, Gimenez, Luis E., Gurevich, Vsevolod V., Spiller, Benjamin W.

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Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias von Mäde, Veronika, Babilon, Stefanie, Jolly, Navjeet, Wanka, Lizzy, Bellmann-Sickert, Kathrin, Diaz Gimenez, Luis E., Mörl, Karin, Cox, Helen M., Gurevich, Vsevolod V., Beck-Sickinger, Annette G.

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Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies von Hernandez, Ciria C, Gimenez, Luis E, Strassmaier, Tim, Rogers, Marc, Taymans, Jean-Marc

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Manipulation of Very Few Receptor Discriminator Residues Greatly Enhances Receptor Specificity of Non-visual Arrestins von Gimenez, Luis E., Vishnivetskiy, Sergey A., Baameur, Faiza, Gurevich, Vsevolod V.

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Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains von Zhan, Xuanzhi, Perez, Alejandro, Gimenez, Luis E., Vishnivetskiy, Sergey A., Gurevich, Vsevolod V.

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A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways von Hu, Jianxin, Stern, Matthew, Gimenez, Luis E., Wanka, Lizzy, Zhu, Lu, Rossi, Mario, Meister, Jaroslawna, Inoue, Asuka, Beck-Sickinger, Annette G., Gurevich, Vsevolod V., Wess, Jürgen

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Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine von Schuermann, Jonathan P., Jiang, Jianwen, Cuellar, Jorge, Llorca, Oscar, Wang, Liping, Gimenez, Luis E., Jin, Suping, Taylor, Alexander B., Demeler, Borries, Morano, Kevin A., Hart, P. John, Valpuesta, Jose M., Lafer, Eileen M., Sousa, Rui

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Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors von Gimenez, Luis E., Kook, Seunghyi, Vishnivetskiy, Sergey A., Ahmed, M. Rafiuddin, Gurevich, Eugenia V., Gurevich, Vsevolod V.

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Modulation of methuselah expression targeted to Drosophila insulin‐producing cells extends life and enhances oxidative stress resistance von Gimenez, Luis E. D., Ghildyal, Parakashtha, Fischer, Kathleen E., Hu, Hongxiang, Ja, William W., Eaton, Benjamin A., Wu, Yimin, Austad, Steven N., Ranjan, Ravi

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Targeting the central melanocortin system for the treatment of metabolic disorders von Sweeney, Patrick, Gimenez, Luis E., Hernandez, Ciria C., Cone, Roger D.

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Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding von Yu, Jing, Gimenez, Luis E, Hernandez, Ciria C, Wu, Yiran, Wein, Ariel H, Han, Gye Won, McClary, Kyle, Mittal, Sanraj R, Burdsall, Kylie, Stauch, Benjamin, Wu, Lijie, Stevens, Sophia N, Peisley, Alys, Williams, Savannah Y, Chen, Valerie, Millhauser, Glenn L, Zhao, Suwen, Cone, Roger D, Stevens, Raymond C

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The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control von Hernandez, Ciria C, Gimenez, Luis E, Dahir, Naima S, Peisley, Alys, Cone, Roger D

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The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a von Rouault, Alix A J, Rosselli-Murai, Luciana K, Hernandez, Ciria C, Gimenez, Luis E, Tall, Gregory G, Sebag, Julien A

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Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2 von Chen, Valerie, Bruno, Antonio E., Britt, Laura L., Hernandez, Ciria C., Gimenez, Luis E., Peisley, Alys, Cone, Roger D., Millhauser, Glenn L.

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Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design von Gimenez, Luis E., Martin, Charlotte, Yu, Jing, Hollanders, Charlie, Hernandez, Ciria C., Wu, Yiran, Yao, Deqiang, Han, Gye Won, Dahir, Naima S., Wu, Lijie, Van der Poorten, Olivier, Lamouroux, Arthur, Mannes, Morgane, Zhao, Suwen, Tourwé, Dirk, Stevens, Raymond C., Cone, Roger D., Ballet, Steven

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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice von Dahir, Naima S, Gui, Yijun, Wu, Yanan, Sweeney, Patrick R, Rouault, Alix Aj, Williams, Savannah Y, Gimenez, Luis E, Sawyer, Tomi K, Joy, Stephen T, Mapp, Anna K, Cone, Roger D

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Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure von Martin, Charlotte, Gimenez, Luis E, Williams, Savannah Y, Jing, Yu, Wu, Yiran, Hollanders, Charlie, Van der Poorten, Olivier, Gonzalez, Simon, Van Holsbeeck, Kevin, Previti, Santo, Lamouroux, Arthur, Zhao, Suwen, Tourwé, Dirk, Stevens, Raymond C, Cone, Roger D, Ballet, Steven

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Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant von Breitman, Maya, Kook, Seunghyi, Gimenez, Luis E, Lizama, Britney N, Palazzo, Maria C, Gurevich, Eugenia V, Gurevich, Vsevolod V

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Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors von Gimenez, Luis E., Baameur, Faiza, Vayttaden, Sharat J., Clark, Richard B.

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Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes von Gimenez, Luis E., Babilon, Stefanie, Wanka, Lizzy, Beck-Sickinger, Annette G., Gurevich, Vsevolod V.

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