A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity von Kim, Tae Whan, Staschke, Kirk, Bulek, Katarzyna, Yao, Jianhong, Peters, Kristi, Oh, Keun-Hee, Vandenburg, Yvonne, Xiao, Hui, Qian, Wen, Hamilton, Tom, Min, Booki, Sen, Ganes, Gilmour, Raymond, Li, Xiaoxia

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Genome of the Bacterium Streptococcus pneumoniae Strain R6 von Hoskins, J, Alborn, Jr, W E, Arnold, J, Blaszczak, L C, Burgett, S, DeHoff, B S, Estrem, S T, Fritz, L, Fu, D J, Fuller, W, Geringer, C, Gilmour, R, Glass, J S, Khoja, H, Kraft, A R, Lagace, R E, LeBlanc, D J, Lee, L N, Lefkowitz, E J, Lu, J, Matsushima, P, McAhren, S M, McHenney, M, McLeaster, K, Mundy, C W, Nicas, T I, Norris, F H, O'Gara, M, Peery, R B, Robertson, G T, Rockey, P, Sun, P M, Winkler, M E, Yang, Y, Young-Bellido, M, Zhao, G, Zook, C A, Baltz, R H, Jaskunas, S R, Rosteck, Jr, P R, Skatrud, P L, Glass, J I

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Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6 von Ng, Wai‐Leung, Robertson, Gregory T., Kazmierczak, Krystyna M., Zhao, Jingyong, Gilmour, Raymond, Winkler, Malcolm E.

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IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease von Staschke, Kirk A, Dong, Sucai, Saha, Joy, Zhao, Jingyong, Brooks, Nathan A, Hepburn, Deena L, Xia, Jinqi, Gulen, Muhammet F, Kang, Zizhen, Altuntas, Cengiz Z, Tuohy, Vincent K, Gilmour, Raymond, Li, Xiaoxia, Na, Songqing

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Global Transcriptional Analysis of clpP Mutations of Type 2 Streptococcus pneumoniae and Their Effects on Physiology and Virulence von Robertson, Gregory T, Ng, Wai-Leung, Foley, Joseph, Gilmour, Raymond, Winkler, Malcolm E

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Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of Streptococcus pneumoniae R6 Challenged with Sublethal Concentrations of Translation Inhibitors von Ng, Wai-Leung, Kazmierczak, Krystyna M, Robertson, Gregory T, Gilmour, Raymond, Winkler, Malcolm E

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New Class of Competitive Inhibitor of Bacterial Histidine Kinases von GILMOUR, Raymond, FOSTER, J. Estelle, WINKLER, Malcolm E, QIN SHENG, MCCLAIN, Jonathan R, RILEY, Anna, SUN, Pei-Ming, NG, Wai-Leung, DALAI YAN, NICAS, Thalia I, HENRY, Kenneth

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A Phase 1 Study of LY3410738, a First-in-Class Covalent Inhibitor of Mutant IDH in Advanced Myeloid Malignancies (Trial in Progress) von Stein, Eytan M., Konopleva, Marina, Gilmour, Raymond, Szpurka, Anna M, Hill, Elizabeth, Ward, Renee, Kantarjian, Hagop M., Dinardo, Courtney D.

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Back to the Future: Therapeutic Targeting of Cancer Cell Metabolism von Gilmour, Raymond, Velasco, Susana

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Essentiality of clpX, but Not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6 von Robertson, Gregory T, Ng, Wai-Leung, Gilmour, Raymond, Winkler, Malcolm E

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Vancomycin Tolerance Induced by Erythromycin but Not by Loss of vncRS, vex3, or pep27 Function in Streptococcus pneumoniae von Robertson, Gregory T, Zhao, Jingyong, Desai, Bhushan V, Coleman, William H, Nicas, Thalia I, Gilmour, Raymond, Grinius, Leo, Morrison, Donald A, Winkler, Malcolm E

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Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity von Campbell, Robert M, Anderson, Bryan D, Brooks, Nathan A, Brooks, Harold B, Chan, Edward M, De Dios, Alfonso, Gilmour, Raymond, Graff, Jeremy R, Jambrina, Enrique, Mader, Mary, McCann, Denis, Na, Songqing, Parsons, Stephen H, Pratt, Susan E, Shih, Chuan, Stancato, Louis F, Starling, James J, Tate, Courtney, Velasco, Juan A, Wang, Yong, Ye, Xiang S

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Abstract 6417: LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of... von Salama, Vivian, Brooks, Nathan, Skwarska, Anna, Kays, Lisa, Milligan, Paul, Newell, Katherine, Roth, Kenneth, Geeganage, Sandaruwan, Gilmour, Raymond, Chan, Steven M., Sarry, Jean-Emmanuel, Sabatier, Mary, DiNardo, Courtney, Konopleva, Marina

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Abstract LB-274: Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1) von Brooks, Nathan, DeWalt, Robin, Boulet, Serge, Lu, ZhaoHai, Kays, Lisa, cavitt, Rachel, Gomez, Sandra, Strelow, John, Milligan, Paul, Roth, Kenneth, Bauer, Renato, Antonysamy, Stephen, Hahn, Patric, Rankovic, Zoran, McCann, Denis, Mo, Gary, Tiu, Ramon, Burkholder, Timothy, Geeganage, Sandaruwan, Gilmour, Raymond

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Abstract 2187: Tryptophan Metabolism Plays a Central Role in Immunosuppression von Geeganage, Sandaruwan, Sams, Lillian, Henry, James, Dorsey, Frank, Roth, Kenneth, Nikolayev, Alexander, Benhadji, Karim, Gilmour, Raymond, Cerezo, Ana, Peregrina, Sandra, Hoyo, Gloria Martínez-del, Campos-Olivas, Ramón, Funes, Juan Manuel, Diezma, Laura, Velasco-Miguel, Susana

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Abstract 513: Investigating the expression of indolamine deoxygenase I (IDO1) and other immune markers in tissue microarrays von Cerezo, Ana, Hoyo, Gloria Martinez-del, Peregrina, Sandra, Mondejar, Tamara, Caleiras, Eduardo, Gonzalez, Patricia, Lospitao, Eva, Hernandez-Tiedra, Sonia, Diezma, Laura, Casas, Estela, Dorsey, Frank, Benhadji, Karim, Gilmour, Raymond, Geeganage, Sandaruwan, Velasco, Susana

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The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis von Kim, Tae Whan, Febbraio, Maria, Robinet, Peggy, Dugar, Brandon, Greene, Diane, Cerny, Anna, Latz, Eicke, Gilmour, Raymond, Staschke, Kirk, Chisolm, Guy, Fox, Paul L, DiCorleto, Paul E, Smith, Jonathan D, Li, Xiaoxia

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Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in precli... von Puca, Loredana, Dowless, Michele S., Perez-Ferreiro, Carmen M., Ortiz-Ruiz, Maria Jesus, Donoho, Gregory P., Capen, Andrew, Huber, Lysiane, Bogner, Sarah M., Fei, Dongling, Manro, Jason R., Yu, Chun Ping, Xu, Wei Guo, Wang, Rui, Chen, Shuang, Hicks, Mark A., Zolfaghari, Parisa, Faber, Andrew, Gilmour, Raymond, Ramstetter, Monica D., Chang, Matthew T., Lallena, Maria Jose, Gong, Xuequian, Hyman, David M., Smyth, Lillian M., Brandhuber, Barbara J., Taylor, Barry S., Klippel, Anke

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Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NFκB Activation von Xiao, Hui, Qian, Wen, Staschke, Kirk, Qian, Youcun, Cui, Grace, Deng, Li, Ehsani, Mariam, Wang, Xiliang, Qian, Yue-Wei, Chen, Zhijian J., Gilmour, Raymond, Jiang, Zhengfan, Li, Xiaoxia

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Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation von Rekhter, Mark, Staschke, Kirk, Estridge, Thomas, Rutherford, Pamela, Jackson, Nancy, Gifford-Moore, Donetta, Foxworthy, Patricia, Reidy, Charles, Huang, Xiao-di, Kalbfleisch, Michael, Hui, Kwan, Kuo, Ming-Shang, Gilmour, Raymond, Vlahos, Chris J.

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