Delineating the role of cooperativity in the design of potent PROTACs for BTK von Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors von Lanning, Bryan R, Whitby, Landon R, Dix, Melissa M, Douhan, John, Gilbert, Adam M, Hett, Erik C, Johnson, Theodore O, Joslyn, Chris, Kath, John C, Niessen, Sherry, Roberts, Lee R, Schnute, Mark E, Wang, Chu, Hulce, Jonathan J, Wei, Baoxian, Whiteley, Laurence O, Hayward, Matthew M, Cravatt, Benjamin F

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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... von Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors von Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye

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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation von McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A

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Translational PK-PD for targeted protein degradation von Bartlett, Derek W, Gilbert, Adam M

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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A kinetic proofreading model for bispecific protein degraders von Bartlett, Derek W., Gilbert, Adam M.

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Inducing protein-protein interactions with molecular glues von Che, Ye, Gilbert, Adam M., Shanmugasundaram, Veerabahu, Noe, Mark C.

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Know your target, know your molecule von Bunnage, Mark E, Gilbert, Adam M, Jones, Lyn H, Hett, Erik C

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes von Zhang, Yuanjin, Liu, Zhonglin, Hirschi, Marscha, Brodsky, Oleg, Johnson, Eric, Won, Sang Joon, Nagata, Asako, Bezwada, Divya, Petroski, Matthew D, Majmudar, Jaimeen D, Niessen, Sherry, VanArsdale, Todd, Gilbert, Adam M, Hayward, Matthew M, Stewart, Al E, Nager, Andrew R, Melillo, Bruno, Cravatt, Benjamin F

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Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs von Dahal, Upendra P, Obach, R. Scott, Gilbert, Adam M

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Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms von Leung, Louis, Yang, Xin, Strelevitz, Timothy J., Montgomery, Justin, Brown, Matthew F., Zientek, Michael A., Banfield, Christopher, Gilbert, Adam M., Thorarensen, Atli, Dowty, Martin E.

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Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons von Gao, Ying, Deng, Kangwen, Cao, Zixuan, Graziani, Edmund I, Gilbert, Adam M, Koehn, Frank E, Wood, Andrew, Doherty, Patrick, Walsh, Frank S

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Structure-Based Approach To Identify 5‑[4-Hydroxyphenyl]­pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators von Unwalla, Ray, Mousseau, James J, Fadeyi, Olugbeminiyi O, Choi, Chulho, Parris, Kevin, Hu, Baihua, Kenney, Thomas, Chippari, Susan, McNally, Christopher, Vishwanathan, Karthick, Kilbourne, Edward, Thompson, Catherine, Nagpal, Sunil, Wrobel, Jay, Yudt, Matthew, Morris, Carl A, Powell, Dennis, Gilbert, Adam M, Chekler, Eugene L. Piatnitski

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Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity von Zhang, Qingzhou, Jiang, Fan, Zhao, Bingchuan, Lin, Huacan, Tian, Yuan, Xie, Mingsheng, Bai, Guoyun, Gilbert, Adam M., Goetz, Gilles H., Liras, Spiros, Mathiowetz, Alan A., Price, David A., Song, Kun, Tu, Meihua, Wu, Yujie, Wang, Tao, Flanagan, Mark E., Wu, Yun-Dong, Li, Zigang

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines von Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F

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Pyrazolidine-3,5-diones and 5-Hydroxy-1H-pyrazol-3(2H)-ones, Inhibitors of UDP-N-acetylenolpyruvyl Glucosamine Reductase von Gilbert, Adam M, Failli, Amedeo, Shumsky, Jay, Yang, Youjun, Severin, Anatoly, Singh, Guy, Hu, William, Keeney, David, Petersen, Peter J, Katz, Alan H

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