Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia von Salih, Helmut Rainer, Antropius, Holger, Gieseke, Friederike, Lutz, Stefan Zoltan, Kanz, Lothar, Rammensee, Hans-Georg, Steinle, Alexander

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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity von Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

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813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro von Imle, Andrea, Altintas, Isil, Nuermberger, Kristina, Blum, Jordan, Krause, Anna-Lena, Toker, Aras, Daszkiewicz, Lidia, Muik, Alexander, Gieseke, Friederike, Ahmadi, Tahamtan, Fellermeier-Kopf, Sina, Kemper, Kristel, Tuereci, Oezlem, Breij, Esther, Sahin, Ugur

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PML domain of PML–RARα blocks senescence to promote leukemia von Korf, Katharina, Wodrich, Harald, Haschke, Alexander, Ocampo, Corinne, Harder, Lena, Gieseke, Friederike, Pollmann, Annika, Dierck, Kevin, Prall, Sebastian, Staege, Hannah, Ma, Hui, Horstmann, Martin A., Evans, Ronald M., Sternsdorf, Thomas

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Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity von Johann, Pascal-David, Vaegler, Martin, Gieseke, Friederike, Mang, Philippa, Armeanu-Ebinger, Sorin, Kluba, Torsten, Handgretinger, Rupert, Müller, Ingo

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561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation... von Muik, Alexander, Altintas, Isil, Kosoff, Rachelle, Gieseke, Friederike, Schödel, Kristina, Salcedo, Theodora, Burm, Saskia, Toker, Aras, Kranz, Lena, Vormehr, Mathias, Eisel, David, Fereshteh, Mark, Türeci, Özlem, Breij, Esther, Ahmadi, Tahamtan, Sahin, Ugur, Jure-Kunkel, Maria

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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors von Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M, Alonso, Guzman, Rodriguez-Ruiz, Maria E, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Salcedo, Theodora W, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S, Toker, Aras, van den Brink, Edward N, Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C W, Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio

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Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist a... von Muik, Alexander, Kosoff, Rachelle, Gieseke, Friederike, Altintas, Isil, Schödel, Kristina, Burm, Saskia, Stanganello, Eliana, Vascotto, Fulvia, Toker, Aras, Adams, Homer, Breij, Esther, Diken, Mustafa, Ahmadi, Tahamtan, Sasser, Kate, Türeci, Özlem, Fereshteh, Mark, Sahin, Ugur, Jure-Kunkel, Maria

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Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNγR1 signaling and IDO expression von Gieseke, Friederike, Schütt, Burkhardt, Viebahn, Susanne, Koscielniak, Ewa, Friedrich, Wilhelm, Handgretinger, Rupert, Müller, Ingo

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Long-Term Follow-Up After the Application of Mesenchymal Stromal Cells in Children and Adolescents with Steroid-Refractory Graft-Versus-Host Disease von Doering, Michaela, Cabanillas Stanchi, Karin Melanie, Lenglinger, Katrin, Treuner, Claudia, Gieseke, Friederike, Erbacher, Annika, Mezger, Markus, Vaegler, Martin, Schlegel, Paul-Gerhardt, Greil, Johann, Bettoni da Cunha Riehm, Claudia, Faul, Christoph, Schumm, Michael, Lang, Peter, Handgretinger, Rupert, Mueller, Ingo

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Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells von Böhringer, Judith, Santer, René, Schumacher, Neele, Gieseke, Friederike, Cornils, Kerstin, Pechan, Maria, Kustermann‐Kuhn, Birgit, Handgretinger, Rupert, Schöls, Ludger, Harzer, Klaus, Krägeloh‐Mann, Ingeborg, Müller, Ingo

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Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of prec... von Wagenaar, Timothy R., Hotz, Christian, Gieseke, Friederike, Cao, Hui, Diekmann, Jan, Diken, Mustafa, Grunwitz, Christian, Hebert, Andy, Hsu, Karl, Jordan, Marie, Kariko, Katalin, Kreiter, Sebastian, Kuhn, Andreas N., Levit, Mikhail, Malkova, Natalia, Masciari, Serena, Pollard, Jack, Qu, Hui, Selmi, Abderaouf, Schlereth, Julia, Sun, Fangxian, Tillmann, Bodo, Tolstykh, Tatiana, Wicke, Lena, Witzel, Sonja, Yu, Qunyan, Zhang, Yu-An, Zheng, Gang, Nabel, Gary, Lager, Joanne, Sahin, Ugur, Wiederschain, Dmitri

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Abstract 3281: GEN1042 (DuoBody-CD40x4-1BB)®in combination with PD-1 blockade reverses T-cell exhaustion in vitro von Spires, Vanessa M., Masters, Gregg, Yu, Christina, Hancock, Matt, Luijten, Monique N., Muik, Alexander, Nuermberger, Kristina, Gieseke, Friederike, Ahmadi, Tahamtan, Türeci, Özlem, Jure-Kunkel, Maria, Sahin, Ugur, Fereshteh, Mark, Adams, Homer C., Blum, Jordan M.

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Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro von Langer, Harald F, Stellos, Konstantinos, Steingen, Caroline, Froihofer, Amrei, Schönberger, Tanja, Krämer, Björn, Bigalke, Boris, May, Andreas E, Seizer, Peter, Müller, Iris, Gieseke, Friederike, Siegel-Axel, Dorothea, Meuth, Sven G, Schmidt, Annette, Wendel, Hans P, Müller, Ingo, Bloch, Wilhelm, Gawaz, Meinrad

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Siglec‐7 tetramers characterize B‐cell subpopulations and leukemic blasts von Gieseke, Friederike, Mang, Philippa, Viebahn, Susanne, Sonntag, Inga, Kruchen, Anne, Erbacher, Annika, Pfeiffer, Matthias, Handgretinger, Rupert, Müller, Ingo

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The PML domain of PML-RAR[Alpha] blocks senescence to promote leukemia von Korf, Katharina, Wodrich, Harald, Haschke, Alexander, Ocampo, Corinne, Harder, Lena, Gieseke, Friederike, Pollmann, Annika, Dierck, Kevin, Prall, Sebastian, Staege, Hannah, Ma, Hui, Horstmann, Martin A, Evans, Ronald M, Sternsdorf, Thomas

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Hematopoietic Stem Cell Therapy In Eight Patients with Metachromatic Leukodystrophy – Relevance of Post-Transplant Medication von Böhringer, Judith, Kustermann-Kuhn, Birgit, Gieseke, Friederike, Erbacher, Annika, Döring, Michaela, Kehrer, Christiane, Lang, Peter, Krägeloh-Mann, Ingeborg, Handgretinger, Rupert, Müller, Ingo

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Pediatric T-ALL but Not cALL Blasts Express Ligands for Siglec-7 Inhibiting NK Cell Mediated Lysis von Viebahn, Susanne, Gieseke, Friederike, Pfeiffer, Matthias, Handgretinger, Rupert, Müller, Ingo

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WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G sub(0)/G sub(1) phase von Kerst, Gunter, Bergold, Nina, Viebahn, Susanne, Gieseke, Friederike, Kalinova, Marketa, Trka, Jan, Handgretinger, Rupert, Mueller, Ingo

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AGONISTIC TNF RECEPTOR BINDING AGENTS von Gieseke, Friederike, Satijn, David, Altintas, Isil, Parren, Paul, Sahin, Ugur

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