Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells von Gieseke, Friederike, Böhringer, Judith, Bussolari, Rita, Dominici, Massimo, Handgretinger, Rupert, Müller, Ingo

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Tumor-associated MICA is shed by ADAM proteases von Waldhauer, Inja, Goehlsdorf, Dennis, Gieseke, Friederike, Weinschenk, Toni, Wittenbrink, Mareike, Ludwig, Andreas, Stevanovic, Stefan, Rammensee, Hans-Georg, Steinle, Alexander

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Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1 von Battula, Venkata Lokesh, Treml, Sabrina, Bareiss, Petra M, Gieseke, Friederike, Roelofs, Helene, de Zwart, Peter, Muller, Ingo, Schewe, Bernhard, Skutella, Thomas, Fibbe, Willem E, Kanz, Lothar, Buhring, Hans-Jorg

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Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia von Salih, Helmut Rainer, Antropius, Holger, Gieseke, Friederike, Lutz, Stefan Zoltan, Kanz, Lothar, Rammensee, Hans-Georg, Steinle, Alexander

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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation von Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity von Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

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813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro von Imle, Andrea, Altintas, Isil, Nuermberger, Kristina, Blum, Jordan, Krause, Anna-Lena, Toker, Aras, Daszkiewicz, Lidia, Muik, Alexander, Gieseke, Friederike, Ahmadi, Tahamtan, Fellermeier-Kopf, Sina, Kemper, Kristel, Tuereci, Oezlem, Breij, Esther, Sahin, Ugur

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Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans von Fellermeier-Kopf, Sina, Gieseke, Friederike, Sahin, Ugur, Müller, Dafne, Pfizenmaier, Klaus, Kontermann, Roland E.

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PML domain of PML–RARα blocks senescence to promote leukemia von Korf, Katharina, Wodrich, Harald, Haschke, Alexander, Ocampo, Corinne, Harder, Lena, Gieseke, Friederike, Pollmann, Annika, Dierck, Kevin, Prall, Sebastian, Staege, Hannah, Ma, Hui, Horstmann, Martin A., Evans, Ronald M., Sternsdorf, Thomas

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Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity von Johann, Pascal-David, Vaegler, Martin, Gieseke, Friederike, Mang, Philippa, Armeanu-Ebinger, Sorin, Kluba, Torsten, Handgretinger, Rupert, Müller, Ingo

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561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation... von Muik, Alexander, Altintas, Isil, Kosoff, Rachelle, Gieseke, Friederike, Schödel, Kristina, Salcedo, Theodora, Burm, Saskia, Toker, Aras, Kranz, Lena, Vormehr, Mathias, Eisel, David, Fereshteh, Mark, Türeci, Özlem, Breij, Esther, Ahmadi, Tahamtan, Sahin, Ugur, Jure-Kunkel, Maria

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Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells von Holzwarth, Christina, Vaegler, Martin, Gieseke, Friederike, Pfister, Stefan M, Handgretinger, Rupert, Kerst, Gunter, Müller, Ingo

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Proinflammatory stimuli induce galectin‐9 in human mesenchymal stromal cells to suppress T‐cell proliferation von Gieseke, Friederike, Kruchen, Anne, Tzaribachev, Nikolay, Bentzien, Frank, Dominici, Massimo, Müller, Ingo

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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors von Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M, Alonso, Guzman, Rodriguez-Ruiz, Maria E, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Salcedo, Theodora W, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S, Toker, Aras, van den Brink, Edward N, Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C W, Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio

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Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion von Höchst, Bastian, Schildberg, Frank A, Sauerborn, Pia, Gäbel, Yvonne A, Gevensleben, Heidrun, Goltz, Diane, Heukamp, Lukas C, Türler, Andreas, Ballmaier, Matthias, Gieseke, Friederike, Müller, Ingo, Kalff, Jörg, Kurts, Christian, Knolle, Percy A, Diehl, Linda

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Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist a... von Muik, Alexander, Kosoff, Rachelle, Gieseke, Friederike, Altintas, Isil, Schödel, Kristina, Burm, Saskia, Stanganello, Eliana, Vascotto, Fulvia, Toker, Aras, Adams, Homer, Breij, Esther, Diken, Mustafa, Ahmadi, Tahamtan, Sasser, Kate, Türeci, Özlem, Fereshteh, Mark, Sahin, Ugur, Jure-Kunkel, Maria

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Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNγR1 signaling and IDO expression von Gieseke, Friederike, Schütt, Burkhardt, Viebahn, Susanne, Koscielniak, Ewa, Friedrich, Wilhelm, Handgretinger, Rupert, Müller, Ingo

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Long-Term Follow-Up After the Application of Mesenchymal Stromal Cells in Children and Adolescents with Steroid-Refractory Graft-Versus-Host Disease von Doering, Michaela, Cabanillas Stanchi, Karin Melanie, Lenglinger, Katrin, Treuner, Claudia, Gieseke, Friederike, Erbacher, Annika, Mezger, Markus, Vaegler, Martin, Schlegel, Paul-Gerhardt, Greil, Johann, Bettoni da Cunha Riehm, Claudia, Faul, Christoph, Schumm, Michael, Lang, Peter, Handgretinger, Rupert, Mueller, Ingo

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Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells von Böhringer, Judith, Santer, René, Schumacher, Neele, Gieseke, Friederike, Cornils, Kerstin, Pechan, Maria, Kustermann‐Kuhn, Birgit, Handgretinger, Rupert, Schöls, Ludger, Harzer, Klaus, Krägeloh‐Mann, Ingeborg, Müller, Ingo

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Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of prec... von Wagenaar, Timothy R., Hotz, Christian, Gieseke, Friederike, Cao, Hui, Diekmann, Jan, Diken, Mustafa, Grunwitz, Christian, Hebert, Andy, Hsu, Karl, Jordan, Marie, Kariko, Katalin, Kreiter, Sebastian, Kuhn, Andreas N., Levit, Mikhail, Malkova, Natalia, Masciari, Serena, Pollard, Jack, Qu, Hui, Selmi, Abderaouf, Schlereth, Julia, Sun, Fangxian, Tillmann, Bodo, Tolstykh, Tatiana, Wicke, Lena, Witzel, Sonja, Yu, Qunyan, Zhang, Yu-An, Zheng, Gang, Nabel, Gary, Lager, Joanne, Sahin, Ugur, Wiederschain, Dmitri

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