Solution Conformations Shed Light on PROTAC Cell Permeability von Atilaw, Yoseph, Poongavanam, Vasanthanathan, Nilsson, Caroline Svensson, Duy Nguyen, Giese, Anja, Meibom, Daniel, Erdelyi, Mate, Kihlberg, Jan

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design von Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells von Giese, Anja Adelina, Babendreyer, Aaron, Krappen, Peter, Gross, Annika, Strnad, Pavel, Düsterhöft, Stefan, Ludwig, Andreas

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Linker-Dependent Folding Rationalizes PROTAC Cell Permeability von Poongavanam, Vasanthanathan, Atilaw, Yoseph, Siegel, Stephan, Giese, Anja, Lehmann, Lutz, Meibom, Daniel, Erdelyi, Mate, Kihlberg, Jan

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Linker-Dependent Folding Rationalizes PROTAC Cell Permeability br von Poongavanam, Vasanthanathan, Atilaw, Yoseph, Siegel, Stephan, Giese, Anja, Lehmann, Lutz, Meibom, Daniel, Erdélyi, Máté, Kihlberg, Jan

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Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells von Babendreyer, Aaron, Rojas-Gonzalez, Diana M., Giese, Anja Adelina, Fellendorf, Sandra, Duesterhoeft, Stefan, Mela, Petra, Ludwig, Andreas

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Status update on iRhom and ADAM17: It's still complicated von Düsterhöft, Stefan, Babendreyer, Aaron, Giese, Anja Adelina, Flasshove, Charlotte, Ludwig, Andreas

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Deletion of the LIME adaptor protein minimally affects T and B cell development and function von Grégoire, Claude, Simova, Sarka, Wang, Ying, Sansoni, Amandine, Richelme, Sylvie, Schmidt-Giese, Anja, Simeoni, Luca, Angelisova, Pavla, Reinhold, Dirk, Schraven, Burkhart, Horejsi, Vaclav, Malissen, Bernard, Malissen, Marie

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Real-World Use of Therapeutic Anticoagulation in Patients with Paroxysmal Nocturnal Hemoglobinuria. Results of a Survey of Physicians in Australia von Szer, Jeffrey, Forsyth, Cecily J, Giese, Anja

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MO053INHIBITION OF SODIUM PHOSPHATE TRANSPORTER NPT2A IMPROVES EXPERIMENTAL VASCULAR CALCIFICATION AND PHOSPHATE HOMEOSTASIS IN RATS von Klar, Juergen, Anja, Giese, Ehrmann, Alexander, Thiel, Christoph, Riedl, Bernd, Eitner, Frank

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A Preliminary Study of Microplastic Abrasion from the Screw Cap System of Reusable Plastic Bottles by Raman Microspectroscopy von Giese, Anja, Kerpen, Jutta, Weber, Felix, Prediger, Jürgen

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Predictive Modeling of PROTAC Cell Permeability with Machine Learning von Poongavanam, Vasanthanathan, Kölling, Florian, Giese, Anja, Göller, Andreas H., Lehmann, Lutz, Meibom, Daniel, Kihlberg, Jan

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Abstract 2907: Identification and optimization of a novel NAMPT inhibitor-based ADC payload class for cancer therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Giese, Anja, Günther, Judith, Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Beier, Rudolf, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Rottmann, Antje, Erkelenz, Michael, Barak, Naomi, Bömer, Ulf, Mumber, Dominik, Kreft, Bertolt, Linden, Lars, Nising, Carl Friedrich, Weinmann, Hilmar

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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications von Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

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Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target von Ellermann, Manuel, Giese, Anja, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Rahm, Fredrik, Viklund, Jenny, Andersson, Martin, Ginman, Tobias, Forsblom, Rickard, Lindström, Johan, Trésaugues, Lionel, Gorjanacz, Matyas

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Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 von Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

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Predictive Modeling of PROTAC Cell Permeability with Machine Learning von Poongavanam, Vasanthanathan, Kölling, Florian, Giese, Anja, Göller, Andreas H, Lehmann, Lutz, Meibom, Daniel, Kihlberg, Jan

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Inhibition of the growth of Toxoplasma gondii in immature human dendritic cells is dependent on the expression of TNF-alpha receptor 2 von Giese, Anja, Stuhlsatz, Silke, Däubener, Walter, MacKenzie, Colin R

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