Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases von Rivara, Silvia, Milazzo, Ferdinando M, Giannini, Giuseppe

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Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation von Coni, Sonia, Serrao, Silvia Maria, Yurtsever, Zuleyha Nihan, Di Magno, Laura, Bordone, Rosa, Bertani, Camilla, Licursi, Valerio, Ianniello, Zaira, Infante, Paola, Moretti, Marta, Petroni, Marialaura, Guerrieri, Francesca, Fatica, Alessandro, Macone, Alberto, De Smaele, Enrico, Di Marcotullio, Lucia, Giannini, Giuseppe, Maroder, Marella, Agostinelli, Enzo, Canettieri, Gianluca

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Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase von Pala, Daniele, Rivara, Silvia, Mor, Marco, Milazzo, Ferdinando Maria, Roscilli, Giuseppe, Pavoni, Emiliano, Giannini, Giuseppe

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An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy von Sibilio, Pasquale, Belardinilli, Francesca, Licursi, Valerio, Paci, Paola, Giannini, Giuseppe

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A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors von Di Giulio, Stefano, Colicchia, Valeria, Pastorino, Fabio, Pedretti, Flaminia, Fabretti, Francesca, Nicolis di Robilant, Vittoria, Ramponi, Valentina, Scafetta, Giorgia, Moretti, Marta, Licursi, Valerio, Belardinilli, Francesca, Peruzzi, Giovanna, Infante, Paola, Goffredo, Bianca Maria, Coppa, Anna, Canettieri, Gianluca, Bartolazzi, Armando, Ponzoni, Mirco, Giannini, Giuseppe, Petroni, Marialaura

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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma von Veschi, Veronica, Liu, Zhihui, Voss, Ty C., Ozbun, Laurent, Gryder, Berkley, Yan, Chunhua, Hu, Ying, Ma, Anqi, Jin, Jian, Mazur, Sharlyn J., Lam, Norris, Souza, Barbara K., Giannini, Giuseppe, Hager, Gordon L., Arrowsmith, Cheryl H., Khan, Javed, Appella, Ettore, Thiele, Carol J.

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True conversions from RAS mutant to RAS wild-type in circulating tumor DNA from metastatic colorectal cancer patients as assessed by methylation and mutational signature von Nicolazzo, Chiara, Barault, Ludovic, Caponnetto, Salvatore, De Renzi, Gianluigi, Belardinilli, Francesca, Bottillo, Irene, Bargiacchi, Simone, Macagno, Marco, Grammatico, Paola, Giannini, Giuseppe, Cortesi, Enrico, Di Nicolantonio, Federica, Gazzaniga, Paola

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Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth von Maresca, Luisa, Crivaro, Enrica, Migliorini, Francesca, Anichini, Giulia, Giammona, Alessandro, Pepe, Sara, Poggialini, Federica, Vagaggini, Chiara, Giannini, Giuseppe, Sestini, Serena, Borgognoni, Lorenzo, Lapucci, Andrea, Dreassi, Elena, Taddei, Maurizio, Manetti, Fabrizio, Petricci, Elena, Stecca, Barbara

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Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor von Tassone, Giusy, Mazzorana, Marco, Mangani, Stefano, Petricci, Elena, Cini, Elena, Giannini, Giuseppe, Pozzi, Cecilia, Maramai, Samuele

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A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer von Viel, Alessandra, Bruselles, Alessandro, Meccia, Ettore, Fornasarig, Mara, Quaia, Michele, Canzonieri, Vincenzo, Policicchio, Eleonora, Urso, Emanuele Damiano, Agostini, Marco, Genuardi, Maurizio, Lucci-Cordisco, Emanuela, Venesio, Tiziana, Martayan, Aline, Diodoro, Maria Grazia, Sanchez-Mete, Lupe, Stigliano, Vittoria, Mazzei, Filomena, Grasso, Francesca, Giuliani, Alessandro, Baiocchi, Marta, Maestro, Roberta, Giannini, Giuseppe, Tartaglia, Marco, Alexandrov, Ludmil B., Bignami, Margherita

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Circulating Cancer-Associated Macrophage-like Cells as a Blood-Based Biomarker of Response to Immune Checkpoint Inhibitors von Magri, Valentina, De Renzi, Gianluigi, Marino, Luca, De Meo, Michela, Siringo, Marco, Gelibter, Alain, Gareri, Roberta, Cataldi, Chiara, Giannini, Giuseppe, Santini, Daniele, Nicolazzo, Chiara, Gazzaniga, Paola

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ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP von Bufalieri, Francesca, Infante, Paola, Bernardi, Flavia, Caimano, Miriam, Romania, Paolo, Moretti, Marta, Lospinoso Severini, Ludovica, Talbot, Julie, Melaiu, Ombretta, Tanori, Mirella, Di Magno, Laura, Bellavia, Diana, Capalbo, Carlo, Puget, Stéphanie, De Smaele, Enrico, Canettieri, Gianluca, Guardavaccaro, Daniele, Busino, Luca, Peschiaroli, Angelo, Pazzaglia, Simonetta, Giannini, Giuseppe, Melino, Gerry, Locatelli, Franco, Gulino, Alberto, Ayrault, Olivier, Fruci, Doriana, Di Marcotullio, Lucia

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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module von Di Magno, Laura, Manni, Simona, Di Pastena, Fiorella, Coni, Sonia, Macone, Alberto, Cairoli, Sara, Sambucci, Manolo, Infante, Paola, Moretti, Marta, Petroni, Marialaura, Nicoletti, Carmine, Capalbo, Carlo, De Smaele, Enrico, Di Marcotullio, Lucia, Giannini, Giuseppe, Battistini, Luca, Goffredo, Bianca Maria, Iorio, Egidio, Agostinelli, Enzo, Maroder, Marella, Canettieri, Gianluca

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PIK3CA somatic mutation in sinonasal teratocarcinosarcoma von Belardinilli, Francesca, De Vincentiis, Ludovica, D'Ecclesia, Aurelio, Giannini, Giuseppe, Giangaspero, Felice, Corsi, Alessandro

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Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions von Capuano, Cristina, De Federicis, Davide, Ciuti, Daniel, Turriziani, Ombretta, Angeloni, Antonio, Anastasi, Emanuela, Giannini, Giuseppe, Belardinilli, Francesca, Molfetta, Rosa, Alvaro, Domenico, Palmieri, Gabriella, Galandrini, Ricciarda

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Genomic landscape and survival analysis of ctDNA "neo- RAS wild-type" patients with originally RAS mutant metastatic colorectal cancer von Nicolazzo, Chiara, Magri, Valentina, Marino, Luca, Belardinilli, Francesca, Di Nicolantonio, Federica, De Renzi, Gianluigi, Caponnetto, Salvatore, De Meo, Michela, Giannini, Giuseppe, Santini, Daniele, Cortesi, Enrico, Gazzaniga, Paola

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Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy von Coni, Sonia, Antonucci, Laura, D'Amico, Davide, Di Magno, Laura, Infante, Paola, De Smaele, Enrico, Giannini, Giuseppe, Di Marcotullio, Lucia, Screpanti, Isabella, Gulino, Alberto, Canettieri, Gianluca

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MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells von Presutti, Dario, Santini, Simonetta, Cardinali, Beatrice, Papoff, Giuliana, Lalli, Cristiana, Samperna, Simone, Fustaino, Valentina, Giannini, Giuseppe, Ruberti, Giovina

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Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology von Valentini, Virginia, Silvestri, Valentina, Bucalo, Agostino, Conti, Giulia, Karimi, Mina, Di Francesco, Linda, Pomati, Giulia, Mezi, Silvia, Cerbelli, Bruna, Pignataro, Maria Gemma, Nicolussi, Arianna, Coppa, Anna, D'Amati, Giulia, Giannini, Giuseppe, Ottini, Laura

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Modulation of the Heparanase-inhibiting Activity of Heparin through Selective Desulfation, Graded N-Acetylation, and Glycol Splitting von Naggi, Annamaria, Casu, Benito, Perez, Marta, Torri, Giangiacomo, Cassinelli, Giuseppe, Penco, Sergio, Pisano, Claudio, Giannini, Giuseppe, Ishai-Michaeli, Rivka, Vlodavsky, Israel

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