Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling von Haling, Jacob R., Sudhamsu, Jawahar, Yen, Ivana, Sideris, Steve, Sandoval, Wendy, Phung, Wilson, Bravo, Brandon J., Giannetti, Anthony M., Peck, Ariana, Masselot, Alexandre, Morales, Tony, Smith, Darin, Brandhuber, Barbara J., Hymowitz, Sarah G., Malek, Shiva

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity von Maurer, Till, Garrenton, Lindsay S, Oh, Angela, Pitts, Keith, Anderson, Daniel J, Skelton, Nicholas J, Fauber, Benjamin P, Pan, Borlan, Malek, Shiva, Stokoe, David, Ludlam, Mary J. C, Bowman, Krista K, Wu, Jiansheng, Giannetti, Anthony M, Starovasnik, Melissa A, Mellman, Ira, Jackson, Peter K, Rudolph, Joachim, Wang, Weiru, Fang, Guowei

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Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors von Giannetti, Anthony M, Koch, Bruce D, Browner, Michelle F

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The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression von Schmidt, Paul J., Toran, Paul T., Giannetti, Anthony M., Bjorkman, Pamela J., Andrews, Nancy C.

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase von Fauber, Benjamin P., Dragovich, Peter S., Chen, Jinhua, Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Liu, Yingchun, Malek, Shiva, Peterson, David, Pitts, Keith, Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wang, Jing, Wei, BinQing, Yen, Ivana, Yue, Qin

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Docking for fragment inhibitors of AmpC β-lactamase von Teotico, Denise G, Babaoglu, Kerim, Rocklin, Gabriel J, Ferreira, Rafaela S, Giannetti, Anthony M, Shoichet, Brian K

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Molecular Mechanism of the Syk Activation Switch von Tsang, Emily, Giannetti, Anthony M., Shaw, David, Dinh, Marie, Tse, Joyce K.Y., Gandhi, Shaan, Ho, Hoangdung, Wang, Sandra, Papp, Eva, Bradshaw, J. Michael

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase von Dragovich, Peter S., Fauber, Benjamin P., Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Ge, HongXiu, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Malek, Shiva, Pan, Borlan, Peterson, David, Pitts, Keith, Purkey, Hans E., Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wei, BinQing, Xu, Qing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhang, Xuying

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HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface von Giannetti, Anthony M., Björkman, Pamela J.

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Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization von Crawford, Terry D, Ndubaku, Chudi O, Chen, Huifen, Boggs, Jason W, Bravo, Brandon J, DeLaTorre, Kelly, Giannetti, Anthony M, Gould, Stephen E, Harris, Seth F, Magnuson, Steven R, McNamara, Erin, Murray, Lesley J, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Stanley, Mark, Vitorino, Philip, Wang, Lan, West, Kristina, Wu, Ping, Ye, Weilan

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus von Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus

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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 von Heise, Christopher E, Murray, Jeremy, Augustyn, Katherine E, Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M, Gibbons, Paul, Hannoush, Rami N, Hearn, Brian R, Jaishankar, Priyadarshini, Ly, Cuong Q, Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W, Renslo, Adam R, Flygare, John, Arkin, Michelle R

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus von LE POGAM, Sophie, KANG, Hyunsoon, HENDRICKS, Than, KLUMPP, Klaus, SYMONS, Julian, BROWNER, Michelle F, CAMMACK, Nick, NAJERA, Isabel, HARRIS, Seth F, LEVEQUE, Vincent, GIANNETTI, Anthony M, ALI, Samir, JIANG, Wen-Rong, RAJYAGURU, Sonal, TAVARES, Gisele, OSHIRO, Connie

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Mechanism for multiple ligand recognition by the human transferrin receptor von Giannetti, Anthony M, Snow, Peter M, Zak, Olga, Björkman, Pamela J

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From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance von Giannetti, Anthony M

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Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology von Papalia, Giuseppe A., Leavitt, Stephanie, Bynum, Maggie A., Katsamba, Phinikoula S., Wilton, Rosemarie, Qiu, Huawei, Steukers, Mieke, Wang, Siming, Bindu, Lakshman, Phogat, Sanjay, Giannetti, Anthony M., Ryan, Thomas E., Pudlak, Victoria A., Matusiewicz, Katarzyna, Michelson, Klaus M., Nowakowski, Agnes, Pham-Baginski, Anh, Brooks, Jonathan, Tieman, Bryan C., Bruce, Barry D., Vaughn, Michael, Baksh, Michael, Cho, Yun Hee, Wit, Mieke De, Smets, Alexandra, Vandersmissen, Johan, Michiels, Lieve, Myszka, David G.

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Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination von Dueber, Erin C., Schoeffler, Allyn J., Lingel, Andreas, Elliott, J. Michael, Fedorova, Anna V., Giannetti, Anthony M., Zobel, Kerry, Maurer, Brigitte, Varfolomeev, Eugene, Wu, Ping, Wallweber, Heidi J. A., Hymowitz, Sarah G., Deshayes, Kurt, Vucic, Domagoj, Fairbrother, Wayne J.

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Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis von Reif, Karin, Currie, Kevin S, Di Paolo, Julie A, Huang, Tao, Balazs, Mercedesz, Barbosa, James, Barck, Kai H, Bravo, Brandon J, Carano, Richard A D, Darrow, James, Davies, Douglas R, DeForge, Laura E, Diehl, Lauri, Ferrando, Ronald, Gallion, Steven L, Giannetti, Anthony M, Gribling, Peter, Hurez, Vincent, Hymowitz, Sarah G, Jones, Randall, Kropf, Jeffrey E, Lee, Wyne P, Maciejewski, Patricia M, Mitchell, Scott A, Rong, Hong, Staker, Bart L, Whitney, J Andrew, Yeh, Sherry, Young, Wendy B, Yu, Christine, Zhang, Juan

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Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase von Sweeney, Zachary K., Acharya, Sahaja, Briggs, Andrew, Dunn, James P., Elworthy, Todd R., Fretland, Jennifer, Giannetti, Anthony M., Heilek, Gabrielle, Li, Yu, Kaiser, Ann C., Martin, Michael, Saito, Y. David, Smith, Mark, Suh, Judy M., Swallow, Steven, Wu, Jeffrey, Hang, Julie Q., Zhou, Amy S., Klumpp, Klaus

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Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) von Giannetti, Anthony M, Wong, Harvey, Dijkgraaf, Gerrit J. P, Dueber, Erin C, Ortwine, Daniel F, Bravo, Brandon J, Gould, Stephen E, Plise, Emile G, Lum, Bert L, Malhi, Vikram, Graham, Richard A

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