Complementary Asymmetric Routes to (R)‑2-(7-Hydroxy-2,3-dihydro‑1H‑pyrrolo[1,2‑a]indol-1-yl)acetate von Schrader, Thomas O, Johnson, Benjamin R, Lopez, Luis, Kasem, Michelle, Gharbaoui, Tawfik, Sengupta, Dipanjan, Buzard, Daniel, Basmadjian, Christine, Jones, Robert M

Volltext

A Nucleophilic Deprotection of Carbamate Mediated by 2‑Mercaptoethanol von Scattolin, Thomas, Gharbaoui, Tawfik, Chen, Cheng-yi

Volltext

Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a von Skinner, Philip J., Cherrier, Martin C., Webb, Peter J., Shin, Young-Jun, Gharbaoui, Tawfik, Lindstrom, Andrew, Hong, Vu, Tamura, Susan Y., Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme

Volltext

Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol von Guo, Wenxing, Gharbaoui, Tawfik, Lizza, Joseph R., Meng, Fanfan, Wang, Yuanxian, Xin, Maoshu, Chen, Yuanpeng, Li, Jing, Chen, Cheng-yi

Volltext

Development of Adagrasib’s Commercial Manufacturing Route von Snead, David R., Gan, Yonghong, Scattolin, Thomas, Paymode, Dinesh J., Achmatowicz, Michal, Rudisill, Duane E., Vidal, Ephraim S., Gharbaoui, Tawfik, Roberts, Phil, Yang, Jianbo, Shi, Zhangbing, Liu, Wei, Bolger, Joshua, Qiao, Zhen, Chen, Cheng-yi

Volltext

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties von Dyck, Brian, Branstetter, Bryan, Gharbaoui, Tawfik, Hudson, Andrew R, Breitenbucher, J. Guy, Gomez, Laurent, Botrous, Iriny, Marrone, Tami, Barido, Richard, Allerston, Charles K, Cedervall, E. Peder, Xu, Rui, Sridhar, Vandana, Barker, Ryan, Aertgeerts, Kathleen, Schmelzer, Kara, Neul, David, Lee, Dong, Massari, Mark Eben, Andersen, Carsten B, Sebring, Kristen, Zhou, Xianbo, Petroski, Robert, Limberis, James, Augustin, Martin, Chun, Lawrence E, Edwards, Thomas E, Peters, Marco, Tabatabaei, Ali

Volltext

Discovery of 2‑(((1r,4r)‑4-(((4-Chlorophenyl)­(phenyl)­carbamoyl)­oxy)­methyl)­cyclohexyl)­methoxy)­acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Trea... von Tran, Thuy-Anh, Kramer, Bryan, Shin, Young-Jun, Vallar, Pureza, Boatman, P. Douglas, Zou, Ning, Sage, Carleton R., Gharbaoui, Tawfik, Krishnan, Ashwin, Pal, Biman, Shakya, Sagar R., Garrido Montalban, Antonio, Adams, John W., Ramirez, Juan, Behan, Dominic P., Shifrina, Anna, Blackburn, Anthony, Leakakos, Tina, Shi, Yunqing, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Unett, David J., Gaidarov, Ibragim, Chen, Xiaohua, Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme

Volltext

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control von Semple, Graeme, Ren, Albert, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Choi, Karoline, Xiong, Yifeng, Shin, Young-Jun, Gharbaoui, Tawfik, Sage, Carleton R., Morgan, Michael, Xing, Charles, Chu, Zhi-Liang, Leonard, James N., Grottick, Andrew J., Al-Shamma, Hussein, Liang, Yin, Demarest, Keith T., Jones, Robert M.

Volltext

Asymmetric synthesis of ( R)- and ( S)-piperidin-2-yl-phosphonic acid by diastereoselective addition of trialkyl phosphite onto potential iminium salt von Maury, Catherine, Wang, Qian, Gharbaoui, Tawfik, Chiadmi, Mohamed, Tomas, Alain, Royer, Jacques, Husson, Henri-Philippe

Volltext

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor von Buzard, Daniel J, Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J, Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P, Jones, Robert M

Volltext

3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No V... von Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G

Volltext

An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4‑Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene von Sengupta, Dipanjan, Gharbaoui, Tawfik, Krishnan, Ashwin, Buzard, Daniel J, Jones, Robert M, Ma, You-An, Burda, Robert, Garrido Montalban, Antonio, Semple, Graeme

Volltext

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists von Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.

Volltext

Analogues of Acifran:  Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b von Jung, Jae-Kyu, Johnson, Benjamin R, Duong, Tracy, Decaire, Marc, Uy, Jane, Gharbaoui, Tawfik, Boatman, P. Douglas, Sage, Carleton R, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T, Semple, Graeme

Volltext

(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists von Buzard, Daniel J, Lopez, Luis, Moody, Jeanne, Kawasaki, Andrew, Schrader, Thomas O, Kasem, Michelle, Johnson, Ben, Zhu, Xiuwen, Thoresen, Lars, Kim, Sun Hee, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Krishnan, Ashwin, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Chen, Weichao, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Gaidarov, Ibragim, Anthony, Todd, Le, Minh, Unett, David J, Stirn, Scott, Blackburn, Anthony, Behan, Dominic P, Jones, Robert M

Volltext

Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease von Buzard, Daniel J., Han, Sangdon, Lopez, Luis, Kawasaki, Andrew, Moody, Jeanne, Thoresen, Lars, Ullman, Brett, Lehmann, Juerg, Calderon, Imelda, Zhu, Xiuwen, Gharbaoui, Tawfik, Sengupta, Dipanjan, Krishnan, Ashwin, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Thatte, Jayant, Solomon, Michelle, Fu, Lixia, Whelan, Kevin, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, Jones, Robert M.

Volltext

Agonist lead identification for the high affinity niacin receptor GPR109a von Gharbaoui, Tawfik, Skinner, Philip J., Shin, Young-Jun, Averbuj, Claudia, Jung, Jae-Kyu, Johnson, Benjamin R., Duong, Tracy, Decaire, Marc, Uy, Jane, Cherrier, Martin C., Webb, Peter J., Tamura, Susan Y., Zou, Ning, Rodriguez, Nathalie, Boatman, P. Douglas, Sage, Carleton R., Lindstrom, Andrew, Xu, Jerry, Schrader, Thomas O., Smith, Brian M., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Colletti, Steven L., Tata, James R., Semple, Graeme

Volltext

(7-Benzyloxy-2,3-dihydro- 1H -pyrrolo[1,2- a ]indol-1-yl)acetic Acids as S1P 1 Functional Antagonists von Buzard, Daniel J., Lopez, Luis, Moody, Jeanne, Kawasaki, Andrew, Schrader, Thomas O., Kasem, Michelle, Johnson, Ben, Zhu, Xiuwen, Thoresen, Lars, Kim, Sun Hee, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Krishnan, Ashwin, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Chen, Weichao, Christopher, Ronald J., Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Gaidarov, Ibragim, Anthony, Todd, Le, Minh, Unett, David J., Stirn, Scott, Blackburn, Anthony, Behan, Dominic P., Jones, Robert M.

Volltext

PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR von GHARBAOUI, Tawfik, KRISHNAN, Ashwin M

Volltext bestellen

Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor von Gharbaoui, Tawfik, Krishnan, Ashwin M

Volltext bestellen