A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

Volltext

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase von Angst, Daniela, Gessier, François, Janser, Philipp, Vulpetti, Anna, Wälchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred, Funhoff, Enrico G, Pulz, Robert, Cenni, Bruno

Volltext

Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

Volltext

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors von Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

Volltext

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode von Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal

Volltext

Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages von Preuss, Inga, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Bassilana, Frederic, Gessier, Francois, Seuwen, Klaus, Sailer, Andreas W.

Volltext

Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

Volltext

Stereoselective Preparation of 3-Amino-2-fluoro Carboxylic Acid Derivatives, and Their Incorporation in Tetrahydropyrimidin-4(1H)-ones, and in Open-Chain and Cyclic β-Peptides von Yoshinari, Tomohiro, Gessier, François, Noti, Christian, Beck, Albert K., Seebach, Dieter

Volltext

Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV von Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

Volltext

Probing the Proteolytic Stability of β-Peptides Containing α-Fluoro- and α-Hydroxy-β-Amino Acids von Hook, David F, Gessier, François, Noti, Christian, Kast, Peter, Seebach, Dieter

Volltext

On the Way to Glycoprocessing Inhibitors − Synthesis of an Imidazolo-Nectrisine-Phosphono Acid Derivative: A Potential Glycosyltranferase Inhibitor von Tschamber, Théophile, Gessier, François, Neuburger, Markus, Gurcha, Sudagar S., Besra, Gurdyal S., Streith, Jacques

Volltext

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α von Wang, Xiaoliang, Gessier, Francois, Perozzo, Remo, Stojkov, Darko, Hosseini, Aref, Amirshahrokhi, Keyvan, Kuchen, Stefan, Yousefi, Shida, Lötscher, Pius, Simon, Hans-Uwe

Volltext

EBI2 regulates intracellular signaling and migration in human astrocyte von Rutkowska, Aleksandra, Preuss, Inga, Gessier, Francois, Sailer, Andreas W., Dev, Kumlesh K.

Volltext

Abstract 1798: Mechanistic study of NVP-CGM097: a potent, selective and species specific inhibitor of p53-Mdm2 von Valat, Thérèse, Masuya, Keiichi, Baysang, Frédéric, Albrecht, Geneviève, Buschmann, Nicole, Erdmann, Dirk, Furet, Pascal, Gabriel, Tobias, Gessier, François, Hofmann, Francesco, Holzer, Philipp, Kallen, Joerg, Pissot-Solderman, Carole, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien

Volltext

Oxysterols direct immune cell migration via EBI2 von Hannedouche, Sébastien, Zhang, Juan, Yi, Tangsheng, Shen, Weijun, Nguyen, Deborah, Pereira, João P., Guerini, Danilo, Baumgarten, Birgit U., Roggo, Silvio, Wen, Ben, Knochenmuss, Richard, Noël, Sophie, Gessier, Francois, Kelly, Lisa M., Vanek, Mirka, Laurent, Stephane, Preuss, Inga, Miault, Charlotte, Christen, Isabelle, Karuna, Ratna, Li, Wei, Koo, Dong-In, Suply, Thomas, Schmedt, Christian, Peters, Eric C., Falchetto, Rocco, Katopodis, Andreas, Spanka, Carsten, Roy, Marie-Odile, Detheux, Michel, Chen, Yu Alice, Schultz, Peter G., Cho, Charles Y., Seuwen, Klaus, Cyster, Jason G., Sailer, Andreas W.

Volltext

Abstract 1797: Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial von Jeay, Sebastien, Berghausen, Joerg, Buschmann, Nicole, Chène, Patrick, Cozens, Robert, Erdmann, Dirk, Ferretti, Stéphane, Furet, Pascal, Gabriel, Tobias, Gessier, François, Graus-Porta, Diana, Hofmann, Francesco, Holzer, Philipp, Ito, Moriko, Jacoby, Edgar, Jensen, Michael, Kallen, Joerg, Lang, Marc, Lisztwan, Joanna, Murakami, Masato, Pissot-Soldermann, Carole, Ruetz, Stephan, Rynn, Caroline, Sterker, Dario, Stutz, Stefan, Valat, Thérèse, Wiesmann, Marion, Masuya, Keiichi

Volltext

Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation von Pulz, Robert, Angst, Daniela, Dawson, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Zimmerlin, Alfred, Cenni, Bruno

Volltext

Carbohydrate transition state mimics: synthesis of imidazolo-Pyrrolidinoses as potential nectrisine surrogates von Tschamber, Théophile, Gessier, François, Dubost, Estelle, Newsome, Jeffery, Tarnus, Céline, Kohler, Josiane, Neuburger, Markus, Streith, Jacques

Volltext

Synthesis and CD Spectra of Fluoro- and Hydroxy-Substituted β-Peptides von Gessier, François, Noti, Christian, Rueping, Magnus, Seebach, Dieter

Volltext

Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor von Gessier, Francois, Preuss, Inga, Yin, Hong, Rosenkilde, Mette M, Laurent, Stephane, Endres, Ralf, Chen, Yu A, Marsilje, Thomas H, Seuwen, Klaus, Nguyen, Deborah G, Sailer, Andreas W

Volltext