A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase von Angst, Daniela, Gessier, François, Janser, Philipp, Vulpetti, Anna, Wälchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred, Funhoff, Enrico G, Pulz, Robert, Cenni, Bruno

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Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors von Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode von Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal

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Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages von Preuss, Inga, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Bassilana, Frederic, Gessier, Francois, Seuwen, Klaus, Sailer, Andreas W.

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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

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Stereoselective Preparation of 3-Amino-2-fluoro Carboxylic Acid Derivatives, and Their Incorporation in Tetrahydropyrimidin-4(1H)-ones, and in Open-Chain and Cyclic β-Peptides von Yoshinari, Tomohiro, Gessier, François, Noti, Christian, Beck, Albert K., Seebach, Dieter

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On the Way to Glycoprocessing Inhibitors − Synthesis of an Imidazolo-Nectrisine-Phosphono Acid Derivative: A Potential Glycosyltranferase Inhibitor von Tschamber, Théophile, Gessier, François, Neuburger, Markus, Gurcha, Sudagar S., Besra, Gurdyal S., Streith, Jacques

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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV von Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

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Probing the Proteolytic Stability of β-Peptides Containing α-Fluoro- and α-Hydroxy-β-Amino Acids von Hook, David F, Gessier, François, Noti, Christian, Kast, Peter, Seebach, Dieter

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Abstract 1798: Mechanistic study of NVP-CGM097: a potent, selective and species specific inhibitor of p53-Mdm2 von Valat, Thérèse, Masuya, Keiichi, Baysang, Frédéric, Albrecht, Geneviève, Buschmann, Nicole, Erdmann, Dirk, Furet, Pascal, Gabriel, Tobias, Gessier, François, Hofmann, Francesco, Holzer, Philipp, Kallen, Joerg, Pissot-Solderman, Carole, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien

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Abstract 1797: Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial von Jeay, Sebastien, Berghausen, Joerg, Buschmann, Nicole, Chène, Patrick, Cozens, Robert, Erdmann, Dirk, Ferretti, Stéphane, Furet, Pascal, Gabriel, Tobias, Gessier, François, Graus-Porta, Diana, Hofmann, Francesco, Holzer, Philipp, Ito, Moriko, Jacoby, Edgar, Jensen, Michael, Kallen, Joerg, Lang, Marc, Lisztwan, Joanna, Murakami, Masato, Pissot-Soldermann, Carole, Ruetz, Stephan, Rynn, Caroline, Sterker, Dario, Stutz, Stefan, Valat, Thérèse, Wiesmann, Marion, Masuya, Keiichi

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Carbohydrate transition state mimics: synthesis of imidazolo-Pyrrolidinoses as potential nectrisine surrogates von Tschamber, Théophile, Gessier, François, Dubost, Estelle, Newsome, Jeffery, Tarnus, Céline, Kohler, Josiane, Neuburger, Markus, Streith, Jacques

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RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α von Wang, Xiaoliang, Gessier, Francois, Perozzo, Remo, Stojkov, Darko, Hosseini, Aref, Amirshahrokhi, Keyvan, Kuchen, Stefan, Yousefi, Shida, Lötscher, Pius, Simon, Hans-Uwe

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EBI2 regulates intracellular signaling and migration in human astrocyte von Rutkowska, Aleksandra, Preuss, Inga, Gessier, Francois, Sailer, Andreas W., Dev, Kumlesh K.

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Synthesis and CD Spectra of Fluoro- and Hydroxy-Substituted β-Peptides von Gessier, François, Noti, Christian, Rueping, Magnus, Seebach, Dieter

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Amino Pyrimidine Derivatives von VULPETTI, Anna, ANGST, Daniela, GESSIER, François

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Amino pyrimidine derivatives von Angst, Daniela, Vulpetti, Anna, Gessier, François

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Oxysterols direct immune cell migration via EBI2 von Hannedouche, Sébastien, Zhang, Juan, Yi, Tangsheng, Shen, Weijun, Nguyen, Deborah, Pereira, João P., Guerini, Danilo, Baumgarten, Birgit U., Roggo, Silvio, Wen, Ben, Knochenmuss, Richard, Noël, Sophie, Gessier, Francois, Kelly, Lisa M., Vanek, Mirka, Laurent, Stephane, Preuss, Inga, Miault, Charlotte, Christen, Isabelle, Karuna, Ratna, Li, Wei, Koo, Dong-In, Suply, Thomas, Schmedt, Christian, Peters, Eric C., Falchetto, Rocco, Katopodis, Andreas, Spanka, Carsten, Roy, Marie-Odile, Detheux, Michel, Chen, Yu Alice, Schultz, Peter G., Cho, Charles Y., Seuwen, Klaus, Cyster, Jason G., Sailer, Andreas W.

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