P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease von Germann, Ursula A, Alam, John J

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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration von Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.

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Extracellular Signal-Regulated Kinase 2 Is Necessary for Mesoderm Differentiation von Yao Yao, Li, Wei, Wu, Junwei, Germann, Ursula A., Michael S. S. Su, Kuida, Keisuke, Boucher, Diane M.

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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) von Germann, Ursula A, Furey, Brinley F, Markland, William, Hoover, Russell R, Aronov, Alex M, Roix, Jeffrey J, Hale, Michael, Boucher, Diane M, Sorrell, David A, Martinez-Botella, Gabriel, Fitzgibbon, Matthew, Shapiro, Paul, Wick, Michael J, Samadani, Ramin, Meshaw, Kathryn, Groover, Anna, DeCrescenzo, Gary, Namchuk, Mark, Emery, Caroline M, Saha, Saurabh, Welsch, Dean J

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Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes von Jain, Jugnu, Almquist, Susan J., Ford, Pamella J., Shlyakhter, Dina, Wang, Yongping, Nimmesgern, Elmar, Germann, Ursula A.

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Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control von Aronov, Alex M, Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Markland, William, Namchuk, Mark N, Nanthakumar, Suganthini, Poondru, Srinivasu, Straub, Judy, ter Haar, Ernst, Xie, Xiaoling

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Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors von Tsai, Alice W, McNeil, Colleen F, Leeman, Joshua R, Bennett, Hamilton B, Nti-Addae, Kwame, Huang, Cassey, Germann, Ursula A, Byrn, Randal A, Berlioz-Seux, Francoise, Rijnbrand, Rene, Clark, Michael P, Charifson, Paul S, Jones, Steven M

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Flipped Out:  Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors von Aronov, Alex M, Baker, Christopher, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Martinez-Botella, Gabriel, Namchuk, Mark N, Straub, Judy, Tang, Qing, Xie, Xiaoling

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Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-... von Germann, Ursula A, Ford, Pamella J, Shlyakhter, Dina, Mason, Valerie S, Harding, Matthew W

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor von Duffy, John P, Harrington, Edmund M, Salituro, Francesco G, Cochran, John E, Green, Jeremy, Gao, Huai, Bemis, Guy W, Evindar, Ghotas, Galullo, Vincent P, Ford, Pamella J, Germann, Ursula A, Wilson, Keith P, Bellon, Steven F, Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S, Wang, Yow-Ming, Murcko, Mark A, Su, Michael S.S

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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole von Wang, Tiansheng, Duffy, John P, Wang, Jian, Halas, Summer, Salituro, Francesco G, Pierce, Albert C, Zuccola, Harmon J, Black, James R, Hogan, James K, Jepson, Scott, Shlyakter, Dina, Mahajan, Sudipta, Gu, Yong, Hoock, Thomas, Wood, Mark, Furey, Brinley F, Frantz, J. Daniel, Dauffenbach, Lisa M, Germann, Ursula A, Fan, Bin, Namchuk, Mark, Bennani, Youssef L, Ledeboer, Mark W

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Analyzing radiotelemetry data with a mixed model statistical analysis von Hodges, Donald Bartholomew, Song, Tao, Damian, Doris, Germann, Ursula A.

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Both ATP Sites of Human P-Glycoprotein Are Essential but Not Symmetric von Hrycyna, Christine A, Ramachandra, Muralidhara, Germann, Ursula A, Cheng, Priscilla Wu, Pastan, Ira, Gottesman, Michael M

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Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (∗) von Germann, Ursula A., Chambers, Timothy C., Ambudkar, Suresh V., Licht, Thomas, Cardarelli, Carol O., Pastan, Ira, Gottesman, Michael M.

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Structural Flexibility of the Linker Region of Human P-Glycoprotein Permits ATP Hydrolysis and Drug Transport von Hrycyna, Christine A, Airan, Lisa E, Germann, Ursula A, Ambudkar, Suresh V, Pastan, Ira, Gottesman, Michael M

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Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein von Müller, M, Bakos, E, Welker, E, Váradi, A, Germann, U A, Gottesman, M M, Morse, B S, Roninson, I B, Sarkadi, B

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Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro von Germann, Ursula A, Shlyakhter, Dlna, Mason, Valerie S, Zelle, Robert E, Duffy, John P, Galullo, Vincent, Armistead, David M, Saunders, Jeffrey O, Boger, Joshua, Harding, Matthew W

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[31] Baculovirus-mediated expression of human multidrug resistance cDNA in insect cells and functional analysis of recombinant P-glycoprotein von Germann, Ursula A.

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Expression of the human multidrug transporter in insect cells by a recombinant baculovirus von Germann, Ursula A, Willingham, Mark C, Pastan, Ira, Gottesman, Michael M

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Detection of recombinant P-glycoprotein in multidrug resistant cultured cells von GERMANN, U. A

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