RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes von Xin, Yurong, Kim, Jinrang, Okamoto, Haruka, Ni, Min, Wei, Yi, Adler, Christina, Murphy, Andrew J., Yancopoulos, George D., Lin, Calvin, Gromada, Jesper

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Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma von Rabe, Klaus F, Nair, Parameswaran, Brusselle, Guy, Maspero, Jorge F, Castro, Mario, Sher, Lawrence, Zhu, Hongjie, Hamilton, Jennifer D, Swanson, Brian N, Khan, Asif, Chao, Jingdong, Staudinger, Heribert, Pirozzi, Gianluca, Antoni, Christian, Amin, Nikhil, Ruddy, Marcella, Akinlade, Bolanle, Graham, Neil M.H, Stahl, Neil, Yancopoulos, George D, Teper, Ariel

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REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters von Baum, Alina, Ajithdoss, Dharani, Copin, Richard, Zhou, Anbo, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Mohammadi, Kusha, Musser, Bret, Atwal, Gurinder S., Oyejide, Adelekan, Goez-Gazi, Yenny, Dutton, John, Clemmons, Elizabeth, Staples, Hilary M., Bartley, Carmen, Klaffke, Benjamin, Alfson, Kendra, Gazi, Michal, Gonzalez, Olga, Dick, Edward, Carrion, Ricardo, Pessaint, Laurent, Porto, Maciel, Cook, Anthony, Brown, Renita, Ali, Vaneesha, Greenhouse, Jack, Taylor, Tammy, Andersen, Hanne, Lewis, Mark G., Stahl, Neil, Murphy, Andrew J., Yancopoulos, George D., Kyratsous, Christos A.

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Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised d... von Wenzel, Sally, Prof, Castro, Mario, MD, Corren, Jonathan, MD, Maspero, Jorge, MD, Wang, Lin, PhD, Zhang, Bingzhi, PhD, Pirozzi, Gianluca, MD, Sutherland, E Rand, MD, Evans, Robert R, PharmD, Joish, Vijay N, PhD, Eckert, Laurent, PhD, Graham, Neil M H, MD, Stahl, Neil, PhD, Yancopoulos, George D, MD, Louis-Tisserand, Mariana, MD, Teper, Ariel, MD

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Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial von Gogishvili, Miranda, Melkadze, Tamar, Makharadze, Tamta, Giorgadze, Davit, Dvorkin, Mikhail, Penkov, Konstantin, Laktionov, Konstantin, Nemsadze, Gia, Nechaeva, Marina, Rozhkova, Irina, Kalinka, Ewa, Gessner, Christian, Moreno-Jaime, Brizio, Passalacqua, Rodolfo, Li, Siyu, McGuire, Kristina, Kaul, Manika, Paccaly, Anne, Quek, Ruben G. W., Gao, Bo, Seebach, Frank, Weinreich, David M., Yancopoulos, George D., Lowy, Israel, Gullo, Giuseppe, Rietschel, Petra

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ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia von Gaudet, Daniel, Gipe, Daniel A, Pordy, Robert, Ahmad, Zahid, Cuchel, Marina, Shah, Prediman K, Chyu, Kuang-Yuh, Sasiela, William J, Chan, Kuo-Chen, Brisson, Diane, Khoury, Etienne, Banerjee, Poulabi, Gusarova, Viktoria, Gromada, Jesper, Stahl, Neil, Yancopoulos, George D, Hovingh, G. Kees

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Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol von Stein, Evan A, Mellis, Scott, Yancopoulos, George D, Stahl, Neil, Logan, Douglas, Smith, William B, Lisbon, Eleanor, Gutierrez, Maria, Webb, Cheryle, Wu, Richard, Du, Yunling, Kranz, Therese, Gasparino, Evelyn, Swergold, Gary D

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Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab von Papadopoulos, Nicholas, Martin, Joel, Ruan, Qin, Rafique, Ashique, Rosconi, Michael P., Shi, Ergang, Pyles, Erica A., Yancopoulos, George D., Stahl, Neil, Wiegand, Stanley J.

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Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging p... von Thaçi, Diamant, Prof, Simpson, Eric L, MD, Beck, Lisa A, Prof, Bieber, Thomas, Prof, Blauvelt, Andrew, MD, Papp, Kim, MD, Soong, Weily, MD, Worm, Margitta, Univ-Prof, Szepietowski, Jacek C, Prof, Sofen, Howard, MD, Kawashima, Makoto, Prof, Wu, Richard, PhD, Weinstein, Steven P, MD, Graham, Neil M H, MD, Pirozzi, Gianluca, MD, Teper, Ariel, MD, Sutherland, E Rand, MD, Mastey, Vera, MS, Stahl, Neil, PhD, Yancopoulos, George D, MD, Ardeleanu, Marius, MD

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Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes von Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.

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Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis von Hamilton, Jennifer D., PhD, Suárez-Fariñas, Mayte, PhD, Dhingra, Nikhil, BS, Cardinale, Irma, MSc, Li, Xuan, PhD, Kostic, Ana, PhD, Ming, Jeffrey E., MD, PhD, Radin, Allen R., MD, Krueger, James G., MD, Graham, Neil, MD, Yancopoulos, George D., MD, PhD, Pirozzi, Gianluca, MD, PhD, Guttman-Yassky, Emma, MD, PhD

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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine von Huber, Samuel, Gagliani, Nicola, Zenewicz, Lauren A., Huber, Francis J., Bosurgi, Lidia, Hu, Bo, Hedl, Matija, Zhang, Wei, O’Connor, William, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Booth, Carmen J., Cho, Judy H., Ouyang, Wenjun, Abraham, Clara, Flavell, Richard A.

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ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion von Gusarova, Viktoria, Alexa, Corey A., Na, Erqian, Stevis, Panayiotis E., Xin, Yurong, Bonner-Weir, Susan, Cohen, Jonathan C., Hobbs, Helen H., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

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Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells von Xin, Yurong, Kim, Jinrang, Ni, Min, Wei, Yi, Okamoto, Haruka, Lee, Joseph, Adler, Christina, Cavino, Katie, Murphy, Andrew J., Yancopoulos, George D., Lin, Hsin Chieh, Gromada, Jesper

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Humanized mouse model supports development, function, and tissue residency of human natural killer cells von Herndler-Brandstetter, Dietmar, Shan, Liang, Yao, Yi, Stecher, Carmen, Plajer, Valerie, Lietzenmayer, Melanie, Strowig, Till, de Zoete, Marcel R., Palm, Noah W., Chen, Jie, Blish, Catherine A., Frleta, Davor, Gurer, Cagan, Macdonald, Lynn E., Murphy, Andrew J., Yancopoulos, George D., Montgomery, Ruth R., Flavell, Richard A.

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Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis von Eichenfield, Lawrence F., Bieber, Thomas, Beck, Lisa A., Simpson, Eric L., Thaçi, Diamant, de Bruin-Weller, Marjolein, Deleuran, Mette, Silverberg, Jonathan I., Ferrandiz, Carlos, Fölster-Holst, Regina, Chen, Zhen, Graham, Neil M. H., Pirozzi, Gianluca, Akinlade, Bolanle, Yancopoulos, George D., Ardeleanu, Marius

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Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants von Simoes, Eric A. F., Forleo-Neto, Eduardo, Geba, Gregory P., Kamal, Mohamed, Yang, Feng, Cicirello, Helen, Houghton, Matthew R., Rideman, Ronald, Zhao, Qiong, Benvin, Sarah L., Hawes, Alicia, Fuller, Erin D., Wloga, Elzbieta, Pizarro, Jose M. Novoa, Munoz, Flor M., Rush, Scott A., McLellan, Jason S., Lipsich, Leah, Stahl, Neil, Yancopoulos, George D., Weinreich, David M., Kyratsous, Christos A., Sivapalasingam, Sumathi

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Glucagon contributes to liver zonation von Cheng, Xiping, Kim, Sun Y., Okamoto, Haruka, Xin, Yurong, Yancopoulos, George D., Murphy, Andrew J., Gromada, Jesper

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Multiple knockout mouse models reveal lincRNAs are required for life and brain development von Sauvageau, Martin, Goff, Loyal A, Lodato, Simona, Bonev, Boyan, Groff, Abigail F, Gerhardinger, Chiara, Sanchez-Gomez, Diana B, Hacisuleyman, Ezgi, Li, Eric, Spence, Matthew, Liapis, Stephen C, Mallard, William, Morse, Michael, Swerdel, Mavis R, D'Ecclessis, Michael F, Moore, Jennifer C, Lai, Venus, Gong, Guochun, Yancopoulos, George D, Frendewey, David, Kellis, Manolis, Hart, Ronald P, Valenzuela, David M, Arlotta, Paola, Rinn, John L

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Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice von Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Sun Y., Cheng, Xiping, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

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