Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders von Di Fabio, Romano, Pellacani, Annalisa, Faedo, Stefania, Roth, Adelheid, Piccoli, Laura, Gerrard, Philip, Porter, Rod A., Johnson, Christopher N., Thewlis, Kevin, Donati, Daniele, Stasi, Luigi, Spada, Simone, Stemp, Geoffrey, Nash, David, Branch, Clive, Kindon, Leanda, Massagrande, Mario, Poffe, Alessandro, Braggio, Simone, Chiarparin, Elisabetta, Marchioro, Carla, Ratti, Emiliangelo, Corsi, Mauro

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Directed Dihydroxylation of Cyclic Allylic Alcohols and Trichloroacetamides Using OsO4/TMEDA von Donohoe, Timothy J, Blades, Kevin, Moore, Peter R, Waring, Michael J, Winter, Jon J. G, Helliwell, Madeleine, Newcombe, Nicholas J, Stemp, Geoffrey

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BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs) von Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical C... von Westaway, Susan M, Brown, Samantha L, Fell, Stephen C. M, Johnson, Christopher N, MacPherson, David T, Mitchell, Darren J, Myatt, James W, Stanway, Steven J, Seal, Jon T, Stemp, Geoffrey, Thompson, Mervyn, Lawless, Kirk, McKay, Fiona, Muir, Alison I, Barford, Jonathan M, Cluff, Chermaine, Mahmood, Sadhia R, Matthews, Kim L, Mohamed, Shiyam, Smith, Beverley, Stevens, Alexander J, Bolton, Victoria J, Jarvie, Emma M, Sanger, Gareth J

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Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): ... von Macdonald, Gregor J, Branch, Clive L, Hadley, Michael S, Johnson, Christopher N, Nash, David J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Winborn, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Watson, Jeannette M, Wood, Martyn, Parker, Steve G, Ashby, Charles R

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A syn selective dihydroxylation of cyclic allylic trichloroacetamides using catalytic osmium tetroxide von Blades, Kevin, Donohoe, Timothy J, Winter, Jonathan J.G, Stemp, Geoffrey

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Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development von Rami, Harshad K., Thompson, Mervyn, Stemp, Geoffrey, Fell, Steve, Jerman, Jeffrey C., Stevens, Alexander J., Smart, Darren, Sargent, Becky, Sanderson, Dominic, Randall, Andrew D., Gunthorpe, Martin J., Davis, John B.

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Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats von Vorel, Stanislav R, Ashby, Charles R., Jr, Paul, Mousumi, Liu, Xinhe, Hayes, Robert, Hagan, Jim J, Middlemiss, Derek N, Stemp, Geoffrey, Gardner, Eliot L

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BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character von Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells von Beswick, Paul, Charrier, Nicolas, Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Gleave, Robert, Hawkins, Julie, Hussain, Ishrut, Johnson, Christopher N., MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Skidmore, John, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Stuart, Alistair, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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The action of diethylaminosulphur trifluoride (dast) on trans-4-amido- 3-Chromanols: Preparation of cis-amidoalcohols via oxazolines von Burrell, Gordon, Evans, John M, Jones, Graham E, Stemp, Geoffrey

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Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1 von Westaway, Susan M., Thompson, Mervyn, Rami, Harshad K., Stemp, Geoffrey, Trouw, Leontine S., Mitchell, Darren J., Seal, Jon T., Medhurst, Stephen J., Lappin, Sarah C., Biggs, James, Wright, James, Arpino, Sandra, Jerman, Jeffrey C., Cryan, Jennifer E., Holland, Vicky, Winborn, Kim Y., Coleman, Tanya, Stevens, Alexander J., Davis, John B., Gunthorpe, Martin J.

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Design and Synthesis of trans - N -[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011):  A Potent and Selective Dopamine D 3 Rec... von Stemp, Geoffrey, Ashmeade, Tracey, Branch, Clive L., Hadley, Michael S., Hunter, A. Jacqueline, Johnson, Christopher N., Nash, David J., Thewlis, Kevin M., Vong, Antonio K. K., Austin, Nigel E., Jeffrey, Phillip, Avenell, Kim Y., Boyfield, Izzy, Hagan, Jim J., Middlemiss, Derek N., Reavill, Charlie, Riley, Graham J., Routledge, Carole, Wood, Martyn

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT 6 receptor antagonists von Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists von AHMED, Mahmood, BRIGGS, Michael A, JOHNSON, Christopher N, MEDHURST, Andrew D, MITCHELL, Darren J, MOSS, Stephen F, POWLES, Jenifer, SEAL, Jon T, STEAN, Tania O, STEMP, Geoffrey, THOMPSON, Mervyn, TRAIL, Brenda, BROMIDGE, Steven M, UPTON, Neil, WINBORN, Kim, WITTY, David R, BUCK, Tania, CAMPBELL, Lorraine, DEEKS, Nigel J, GARNER, Ashley, GORDON, Laurie, HAMPRECHT, Dieter W, HOLLAND, Vicky

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A concise, convergent total synthesis of monocerin von Cassidy, John H, Farthing, Christopher N, Marsden, Stephen P, Pedersen, Anders, Slater, Mark, Stemp, Geoffrey

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3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity von ATKINSON, Peter J, BROMIDGE, Steven M, RAMI, Harshad K, RILEY, Graham J, SCOTT, Claire M, SHAW, Tracey E, STARR, Kathryn R, STEMP, Geoffrey, THEWLIS, Kevin M, THOMAS, David R, THOMPSON, Mervyn, VONG, Antonio K. K, DUXON, Mark S, WATSON, Jeannette M, GASTER, Laramie M, HADLEY, Michael S, HAMMOND, Beverley, JOHNSON, Christopher N, MIDDLEMISS, Derek N, NORTH, Stephanie E, PRICE, Gary W

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Identification of small molecule agonists of the motilin receptor von Heightman, Tom D., Conway, Elizabeth, Corbett, David F., Macdonald, Gregor J., Stemp, Geoffrey, Westaway, Susan M., Celestini, Paolo, Gagliardi, Stefania, Riccaboni, Mauro, Ronzoni, Silvano, Vaidya, Kalindi, Butler, Sharon, McKay, Fiona, Muir, Alison, Powney, Ben, Winborn, Kim, Wise, Alan, Jarvie, Emma M., Sanger, Gareth J.

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SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849 von Witty, David R., Bateson, John H., Hervieu, Guillaume J., Jeffrey, Phillip, Johnson, Christopher N., Muir, Alison I., O’Hanlon, Peter J., Stemp, Geoffrey, Stevens, Alex J., Thewlis, Kevin M., Wilson, Shelagh, Winborn, Kim Y.

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Palladium(0)-Catalysed Arylations using Pyrrole and Indole 2-Boronic Acids von Johnson, Christopher N., Stemp, Geoffrey, Anand, Neel, Stephen, Susanna C., Gallagher, Timothy

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