Drugs for allosteric sites on receptors von Wenthur, Cody J, Gentry, Patrick R, Mathews, Thomas P, Lindsley, Craig W

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Novel Allosteric Modulators of G Protein-coupled Receptors von Gentry, Patrick R., Sexton, Patrick M., Christopoulos, Arthur

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Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isati... von Bridges, Thomas M, Marlo, Joy E, Niswender, Colleen M, Jones, Carrie K, Jadhav, Satyawan B, Gentry, Patrick R, Plumley, Hyekyung C, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W

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Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe von Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.

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Crystal structure of the M₅ muscarinic acetylcholine receptor von Vuckovic, Ziva, Gentry, Patrick R., Berizzi, Alice E., Hirata, Kunio, Varghese, Swapna, Thompson, Geoff, van der Westhuizen, Emma T., Burger, Wessel A. C., Rahmani, Raphaël, Valant, Celine, Langmead, Christopher J., Lindsley, Craig W., Baell, Jonathan B., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur, Thal, David M.

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Synthesis and Structure–Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor von Kennedy, J. Phillip, Bridges, Thomas M., Gentry, Patrick R., Brogan, John T., Kane, Alexander S., Jones, Carrie K., Brady, Ashley E., Shirey, Jana K., Conn, P. Jeffrey, Lindsley, Craig W.

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In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors von Hao, Jijun, Ho, Joshua N, Lewis, Jana A, Karim, Kaleh A, Daniels, R. Nathan, Gentry, Patrick R, Hopkins, Corey R, Lindsley, Craig W, Hong, Charles C

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Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139 von Zhou, Yali, Daver, Henrik, Trapkov, Boris, Wu, Lijie, Wu, Meng, Harpsøe, Kasper, Gentry, Patrick R., Liu, Kaiwen, Larionova, Marina, Liu, Junlin, Chen, Na, Bräuner-Osborne, Hans, Gloriam, David E., Hua, Tian, Liu, Zhi-Jie

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Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139 von Pallareti, Lisa, Rath, Tine F., Trapkov, Boris, Tsonkov, Tsonko, Nielsen, Anders Thorup, Harpsøe, Kasper, Gentry, Patrick R., Bräuner-Osborne, Hans, Gloriam, David E., Foster, Simon R.

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Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators von Berizzi, Alice E., Gentry, Patrick R., Rueda, Patricia, Den Hoedt, Sandra, Sexton, Patrick M., Langmead, Christopher J., Christopoulos, Arthur

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M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location von Foster, Daniel J, Gentry, Patrick R, Lizardi-Ortiz, Jose E, Bridges, Thomas M, Wood, Michael R, Niswender, Colleen M, Sulzer, David, Lindsley, Craig W, Xiang, Zixiu, Conn, P Jeffrey

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Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells von Deng, Yufang, Moo, Ee Von, Almería, Claudia Victoria Pérez, Gentry, Patrick R., Vedel, Line, Mathiesen, Jesper M., Bräuner‐Osborne, Hans

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Identification of a novel scaffold for a small molecule GPR139 receptor agonist von Nøhr, Anne Cathrine, Shehata, Mohamed A., Palmer, Daniel, Pokhrel, Rina, Vallianou, Maria, Foster, Simon R., Gentry, Patrick R., Gloriam, David E., Bräuner-Osborne, Hans

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Crystal structure of the M 5 muscarinic acetylcholine receptor von Vuckovic, Ziva, Gentry, Patrick R, Berizzi, Alice E, Hirata, Kunio, Varghese, Swapna, Thompson, Geoff, van der Westhuizen, Emma T, Burger, Wessel A C, Rahmani, Raphaël, Valant, Celine, Langmead, Christopher J, Lindsley, Craig W, Baell, Jonathan B, Tobin, Andrew B, Sexton, Patrick M, Christopoulos, Arthur, Thal, David M

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Discovery of (S)‑2-Cyclopentyl‑N‑((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro‑1H‑pyrrido[3,4‑b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Pep... von Morris, Lindsey C, Nance, Kellie D, Gentry, Patrick R, Days, Emily L, Weaver, C. David, Niswender, Colleen M, Thompson, Analisa D, Jones, Carrie K, Locuson, Chuck W, Morrison, Ryan D, Daniels, J. Scott, Niswender, Kevin D, Lindsley, Craig W

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Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor von Burger, Wessel A. C, Gentry, Patrick R, Berizzi, Alice E, Vuckovic, Ziva, van der Westhuizen, Emma T, Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W, Sexton, Patrick M, Langmead, Christopher J, Tobin, Andrew B, Christopoulos, Arthur, Valant, Celine, Thal, David M

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Identification of a Novel Allosteric Site at the M 5 Muscarinic Acetylcholine Receptor von Burger, Wessel A C, Gentry, Patrick R, Berizzi, Alice E, Vuckovic, Ziva, van der Westhuizen, Emma T, Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W, Sexton, Patrick M, Langmead, Christopher J, Tobin, Andrew B, Christopoulos, Arthur, Valant, Celine, Thal, David M

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Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges von Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.

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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule von Poslusney, Michael S., Melancon, Bruce J., Gentry, Patrick R., Sheffler, Douglas J., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.

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Discovery and Optimization of Potent and CNS Penetrant M 5 -Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold von Bender, Aaron M, Cho, Hyekyung P, Nance, Kellie D, Lingenfelter, Kaelyn S, Luscombe, Vincent B, Gentry, Patrick R, Voigtritter, Karl, Berizzi, Alice E, Sexton, Patrick M, Langmead, Christopher J, Christopoulos, Arthur, Locuson, Charles W, Bridges, Thomas M, Chang, Sichen, O'Neill, Jordan C, Zhan, Xiaoyan, Niswender, Colleen M, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W

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