Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma von Ikemori, Rafael, Gabasa, Marta, Duch, Paula, Vizoso, Miguel, Bragado, Paloma, Arshakyan, Marselina, Luis, Iuliana-Cristiana, Marín, Albert, Morán, Sebastian, Castro, Manuel, Fuster, Gemma, Gea-Sorli, Sabrina, Jauset, Toni, Soucek, Laura, Montuenga, Luis M, Esteller, Manel, Monsó, Eduard, Peinado, Victor Ivo, Gascon, Pere, Fillat, Cristina, Hilberg, Frank, Reguart, Noemí, Alcaraz, Jordi

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Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma von Duch, Paula, Díaz-Valdivia, Natalia, Ikemori, Rafael, Gabasa, Marta, Radisky, Evette S., Arshakyan, Marselina, Gea-Sorlí, Sabrina, Mateu-Bosch, Anna, Bragado, Paloma, Carrasco, Josep Lluís, Mori, Hidetoshi, Ramírez, Josep, Teixidó, Cristina, Reguart, Noemí, Fillat, Cristina, Radisky, Derek C., Alcaraz, Jordi

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Mutations in TIMM50 cause severe mitochondrial dysfunction by targeting key aspects of mitochondrial physiology von Tort, Frederic, Ugarteburu, Olatz, Texidó, Laura, Gea‐Sorlí, Sabrina, García‐Villoria, Judit, Ferrer‐Cortès, Xènia, Arias, Ángela, Matalonga, Leslie, Gort, Laura, Ferrer, Isidre, Guitart‐Mampel, Mariona, Garrabou, Glòria, Vaz, Frederick M, Pristoupilova, Ana, Rodríguez, María Isabel Esteban, Beltran, Sergi, Cardellach, Francesc, Wanders, Ronald JA, Fillat, Cristina, García‐Silva, María Teresa, Ribes, Antonia

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Release of inflammatory mediators by adipose tissue during acute pancreatitis von Franco-Pons, Neus, Gea-Sorlí, Sabrina, Closa, Daniel

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New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver von Gulfo, Jose, Ledda, Angelo, Gea-Sorlí, Sabrina, Bonjoch, Laia, Closa, Daniel, Grasa, Mar, Esteve, Montserrat

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Activation of lung macrophage subpopulations in experimental acute pancreatitis von Gea-Sorlí, Sabrina, Guillamat, Raquel, Serrano-Mollar, Anna, Closa, Daniel

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Differences in the inflammatory response induced by acute pancreatitis in different white adipose tissue sites in the rat von Gea-Sorlí, Sabrina, Bonjoch, Laia, Closa, Daniel

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Systemic delivery of AAV-GCDH ameliorates HLD-induced phenotype in a glutaric aciduria type I mouse model von Mateu-Bosch, Anna, Segur-Bailach, Eulàlia, Muñoz-Moreno, Emma, Barallobre, María José, Arbonés, Maria Lourdes, Gea-Sorlí, Sabrina, Tort, Frederic, Ribes, Antonia, García-Villoria, Judit, Fillat, Cristina

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In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitis von Gea-Sorlí, Sabrina, Closa, Daniel

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Role of protease-activated receptor 2 in lung injury development during acute pancreatitis in rats von de-Madaria, Enrique, del Mar Francés, María, Gea-Sorlí, Sabrina, Gutiérrez, Luis M, Viniegra, Salvador, Pérez-Mateo, Miguel, Closa, Daniel, Lopez-Font, Inmaculada

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Inhibition of miR-222 by Oncolytic Adenovirus-Encoded miRNA Sponges Promotes Viral Oncolysis and Elicits Antitumor Effects in Pancreatic Cancer Models von Raimondi, Giulia, Gea-Sorlí, Sabrina, Otero-Mateo, Marc, Fillat, Cristina

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Lipids generated during acute pancreatitis increase inflammatory status of macrophages by interfering with their M2 polarization von Bonjoch, Laia, Gea-Sorlí, Sabrina, Closa, Daniel

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Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis von Franco-Pons, Neus, Casas, Josefina, Fabriàs, Gemma, Gea-Sorlí, Sabrina, de-Madaria, Enrique, Gelpí, Emilio, Closa, Daniel

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Modeling Glutaric Aciduria Type I in human neuroblastoma cells recapitulates neuronal damage that can be rescued by gene replacement von Mateu Bosch, Anna, Segur-Bailach, Eulalia, García Villoria, Judit, Gea Sorli, Sabrina, Ruiz, I, Rey Calero, Juan del, Camps, Jordi, Guitart Mampel, Mariona, Garrabou Tornos, Glòria, Tort, Frederic, Ribes, A, Fillat i Fonts, Cristina

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Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial von Alton, Eric W F W, Prof, Armstrong, David K, MB ChB, Ashby, Deborah, Prof, Bayfield, Katie J, BSc, Bilton, Diana, Prof, Bloomfield, Emily V, BSc, Boyd, A Christopher, PhD, Brand, June, BSc, Buchan, Ruaridh, MPharm, Calcedo, Roberto, PhD, Carvelli, Paula, BN, Chan, Mario, MSc, Cheng, Seng H, PhD, Collie, D David S, MRCVS, Cunningham, Steve, MB ChB, Davidson, Heather E, Davies, Gwyneth, MBChB, Davies, Jane C, Prof, Davies, Lee A, DPhil, Dewar, Maria H, BSc, Doherty, Ann, BSc, Donovan, Jackie, PhD, Dwyer, Natalie S, RN, Elgmati, Hala I, MRCP, Featherstone, Rosanna F, BSc, Gavino, Jemyr, RN, Gea-Sorli, Sabrina, PhD, Geddes, Duncan M, Prof, Gibson, James S R, BSc, Gill, Deborah R, PhD, Greening, Andrew P, Prof, Griesenbach, Uta, Prof, Hansell, David M, Prof, Harman, Katharine, MRCPH, Higgins, Tracy E, BSc, Hodges, Samantha L, BSc, Hyde, Stephen C, DPhil, Hyndman, Laura, MSc, Innes, J Alastair, FRCPE, Jacob, Joseph, FRCR, Jones, Nancy, BPharm, Keogh, Brian F, FRCA, Limberis, Maria P, PhD, Lloyd-Evans, Paul, PhD, Maclean, Alan W, BSc, Manvell, Michelle C, BSc, McCormick, Dominique, PhD, McGovern, Michael, MRCP, McLachlan, Gerry, PhD, Meng, Cuixiang, BSc, Montero, M Angeles, MD, Milligan, Hazel, BSc, Moyce, Laura J, BSc, Murray, Gordon D, Prof, Nicholson, Andrew G, Prof, Osadolor, Tina, MSc, Parra-Leiton, Javier, Porteous, David J, Prof, Pringle, Ian A, DPhil, Punch, Emma K, BSc, Pytel, Kamila M, PhD, Quittner, Alexandra L, Prof, Rivellini, Gina, Saunders, Clare J, BSc, Scheule, Ronald K, PhD, Sheard, Sarah, FRCR, Simmonds, Nicholas J, FRCP, Smith, Keith, BSc, Smith, Stephen N, PhD, Soussi, Najwa, BSc, Soussi, Samia, BSc, Spearing, Emma J, MSc, Stevenson, Barbara J, BSc, Sumner-Jones, Stephanie G, PhD, Turkkila, Minna, BSc, Ureta, Rosa P, BN, Waller, Michael D, MRCP, Wasowicz, Marguerite Y, PhD, Wilson, James M, Prof, Wolstenholme-Hogg, Paul, PhD

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Minocycline inhibits peritoneal macrophages but activates alveolar macrophages in acute pancreatitis von Bonjoch, Laia, Gea-Sorlí, Sabrina, Jordan, Joaquin, Closa, Daniel

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Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis von Alton, Eric W F W, Beekman, Jeffery M, Boyd, A Christopher, Brand, June, Carlon, Marianne S, Connolly, Mary M, Chan, Mario, Conlon, Sinead, Davidson, Heather E, Davies, Jane C, Davies, Lee A, Dekkers, Johanna F, Doherty, Ann, Gea-Sorli, Sabrina, Gill, Deborah R, Griesenbach, Uta, Hasegawa, Mamoru, Higgins, Tracy E, Hironaka, Takashi, Hyndman, Laura, McLachlan, Gerry, Inoue, Makoto, Hyde, Stephen C, Innes, J Alastair, Maher, Toby M, Moran, Caroline, Meng, Cuixiang, Paul-Smith, Michael C, Pringle, Ian A, Pytel, Kamila M, Rodriguez-Martinez, Andrea, Schmidt, Alexander C, Stevenson, Barbara J, Sumner-Jones, Stephanie G, Toshner, Richard, Tsugumine, Shu, Wasowicz, Marguerite W, Zhu, Jie

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Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma von Duch, Paula, Díaz Valdivia, Natalia, Ikemori, Rafael, Gabasa Ferràndez, Marta, Radisky, Evette S, Arshakyan, Marselina, Gea Sorli, Sabrina, Mateu Bosch, Anna, Bragado Domingo, Paloma, Carrasco, Josep Lluís, Mori, Hidetoshi, Ramírez Ruz, J. (José), Teixidó, Cristina, Reguart, Noemí, Fillat i Fonts, Cristina, Radisky, Derek C, Alcaraz Casademunt, Jordi

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Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis von Lopez-Font, Inmaculada, Gea-Sorlí, Sabrina, de-Madaria, Enrique, Gutiérrez, Luis M, Pérez-Mateo, Miguel, Closa, Daniel

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Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer von Ikemori, Rafael, Gabasa, Marta, Vizoso, Miguel, Duch, Paula, Moran, Sebastian, Gea-Sorli, Sabrina, Bragado, Paloma, Jauset, Toni, Esteller, Manel, Soucek, Laura, Monsó, Eduard, Peinado, Víctor, Fillat, Cristina, Hilberg, Frank, Reguart, Noemí, Alcaraz, Jordi

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