Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201 von Jeay, Sébastien, Ferretti, Stéphane, Holzer, Philipp, Fuchs, Jeanette, Chapeau, Emilie A, Wartmann, Markus, Sterker, Dario, Romanet, Vincent, Murakami, Masato, Kerr, Grainne, Durand, Eric Y, Gaulis, Swann, Cortes-Cros, Marta, Ruetz, Stephan, Stachyra, Therese-Marie, Kallen, Joerg, Furet, Pascal, Würthner, Jens, Guerreiro, Nelson, Halilovic, Ensar, Jullion, Astrid, Kauffmann, Audrey, Kuriakose, Emil, Wiesmann, Marion, Jensen, Michael R, Hofmann, Francesco, Sellers, William R

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PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma von Bleu, Melusine, Gaulis, Swann, Lopes, Rui, Sprouffske, Kathleen, Apfel, Verena, Holwerda, Sjoerd, Pregnolato, Marco, Yildiz, Umut, Cordoʹ, Valentina, Dost, Antonella F. M., Knehr, Judith, Carbone, Walter, Lohmann, Felix, Lin, Charles Y., Bradner, James E., Kauffmann, Audrey, Tordella, Luca, Roma, Guglielmo, Galli, Giorgio G.

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FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF‐23 signaling and regulating FGF‐23 expression in bone von Wöhrle, Simon, Bonny, Olivier, Beluch, Noemie, Gaulis, Swann, Stamm, Christelle, Scheibler, Marcel, Müller, Matthias, Kinzel, Bernd, Thuery, Anne, Brueggen, Joseph, Hynes, Nancy E, Sellers, William R, Hofmann, Francesco, Graus‐Porta, Diana

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Benchmarking tools for transcription factor prioritization von Santana, Leonor Schubert, Reyes, Alejandro, Hoersch, Sebastian, Ferrero, Enrico, Kolter, Christian, Gaulis, Swann, Steinhauser, Sebastian

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Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations von Brachmann, Saskia M, Kleylein-Sohn, Julia, Gaulis, Swann, Kauffmann, Audrey, Blommers, Marcel J J, Kazic-Legueux, Malika, Laborde, Laurent, Hattenberger, Marc, Stauffer, Fabian, Vaxelaire, Juliane, Romanet, Vincent, Henry, Chrystèle, Murakami, Masato, Guthy, Daniel Alexander, Sterker, Dario, Bergling, Sebastian, Wilson, Christopher, Brümmendorf, Thomas, Fritsch, Christine, Garcia-Echeverria, Carlos, Sellers, William R, Hofmann, Francesco, Maira, Sauveur-Michel

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A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway von Dafflon, Caroline, Gaulis, Swann, Barys, Louise, Kapur, Karen, Cornacchione, Vanessa, Schukur, Lina, Bergling, Sebastian, Traggiai, Elisabetta, Jansky, Selina, Hellmann, Leon, Engstler, Barbara Schacher, Kerr, Grainne, de Weck, Antoine, Ruddy, David A, Naumann, Ulrike, Stauffer, Frédéric, Gaul, Christoph, Lin, Ying, Billy, Eric, Weiss, Andreas, Hofmann, Francesco, Ito, Moriko, Tiedt, Ralph

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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients von Joutel, A, Andreux, F, Gaulis, S, Domenga, V, Cecillon, M, Battail, N, Piga, N, Chapon, F, Godfrain, C, Tournier-Lasserve, E

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Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis von do Valle Duraes, Fernanda, Lafont, Armelle, Beibel, Martin, Martin, Kea, Darribat, Katy, Cuttat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Mertz, Kirsten D, Li, Jianping, Roma, Guglielmo, Warncke, Max

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Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa von Macchiarella, Giulio, Cornacchione, Vanessa, Cojean, Celine, Riker, Julia, Wang, Yichen, Te, Helene, Ceci, Melanie, Gudjonsson, Johann E., Gaulis, Swann, Goetschy, Jean François, Wollschlegel, Audrey, Gass, Stephanie K., Oetliker-Contin, Sofia, Wettstein-Ling, Barbara, Schaefer, Dirk J., Meschberger, Pascale, de Roche, Roland, Osinga, Rik, Wieczorek, Grazyna, Naumann, Ulrike, Lehmann, Joachim C.U., Schubart, Anna, Hofmann, Andreas, Roth, Lukas, Florencia, Edwin F., Loesche, Christian, Traggiai, Elisabetta, Avrameas, Alexandre, Prens, Errol P., Röhn, Till A., Roediger, Ben

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Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers von Wang, Hui Qin, Liang, Jinsheng, Mulford, Iain, Sharp, Fiona, Gaulis, Swann, Chen, Yan, Trabucco, Gina, Quinn, David, Growney, Joseph D., Meyer, Matthew J., Williams, Juliet, Hammerman, Peter, Hofmann, Francesco, Dranoff, Glenn, Engelman, Jeffrey, Mataraza, Jennifer, Halilovic, Ensar

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Discovery of new potential antigens for cancer immunotherapy using “custom tissue” screening of a database of expressed sequence tags von Vinals, Carla, Gaulis, Swann, Cassart, Jean-Pol, Coche, Thierry

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Identification of elongation factor G as the conserved cellular target of argyrin B von Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina A, Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth E, Woods, Angela L, Jones, Adriana K, Barnes, S Whitney, Walker, John R, Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia M, Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, N Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory A, McAllister, Gregory, Murphy, Leon O, Tallarico, John A, Wilson, Christopher J, Dean, Charles R

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Abstract 2909: A gene signature composed of 13 p53 target genes predicts for response to NVP-CGM097, a novel p53-Mdm2 inhibitor, in cell lines and in human primary tumor xenograft... von Jeay, Sebastien, Gaulis, Swann, Ferretti, Stéphane, Albrecht, Geneviève, Barys, Louise, Guthy, Daniel, Halilovic, Ensar, Ito, Moriko, Murakami, Masato, Pornon, Astrid, Ruetz, Stephan, Venkatesan, Kavitha, Yu, Jianjun, Jensen, Michael, Wiesmann, Marion, Wuerthner, Jens, Graus-Porta, Diana

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Abstract 4466: Characterization of the pan class I PI3K inhibitor NVP-BKM120 mechanism of action across a broad range of concentrations von Brachmann, Saskia M., Kleylein-Sohn, Julia, Gaulis, Swann, Stauffer, Frederic, Voshol, Johannes, Guthy, Daniel, Wilson, Christopher, Huang, Alan, Wartmann, Markus, Bruemmendorf, Thomas, Chene, Patrick, Fritsch, Christine, Hackl, Wolfgang, Cosaert, Jan, Schnell, Christian, Hofmann, Francesco, Maira, Michel

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Benchmarking tools for transcription factor prioritization von Steinhauser, Sebastian, Schubert Santana, Leonor, Swann, Gaulis

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MARKERS ASSOCIATED WITH SENSITIVITY TO INHIBITORS OF HUMAN DOUBLE MINUTE 2 (MDM2) von GAULIS, Swann, JEAY, Sebastien

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MARKERS ASSOCIATED WITH SENSITIVITY TO INHIBITORS OF HUMAN DOUBLE MINUTE 2 (MDM2) von GAULIS, SWANN, JEAY, SEBASTIEN

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MARKERS ASSOCIATED WITH SENSITIVITY TO INHIBITORS OF HUMAN DOUBLE MINUTE 2 (MDM2) von GAULIS Swann, JEAY Sebastien

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