Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics von Candelli, Tito, Schneider, Pauline, Garrido Castro, Patricia, Jones, Luke A., Bodewes, Eduard, Rockx-Brouwer, Dedeke, Pieters, Rob, Holstege, Frank C. P., Margaritis, Thanasis, Stam, Ronald W.

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Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4 + Infant ALL von Bardini, Michela, Trentin, Luca, Rizzo, Francesca, Vieri, Margherita, Savino, Angela M, Garrido Castro, Patricia, Fazio, Grazia, Van Roon, Eddy H J, Kerstjens, Mark, Smithers, Nicholas, Prinjha, Rab K, Te Kronnie, Geertruy, Basso, Giuseppe, Stam, Ronald W, Pieters, Rob, Biondi, Andrea, Cazzaniga, Gianni

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Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia von Kerstjens, Mark, Garrido Castro, Patricia, Pinhanços, Sandra S., Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W.

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High-Throughput Drug Library Screening in Primary KMT2A -Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling von Wander, Priscilla, Arentsen-Peters, Susan T C J M, Vrenken, Kirsten S, Pinhanҫos, Sandra Mimoso, Koopmans, Bianca, Dolman, M Emmy M, Jones, Luke, Garrido Castro, Patricia, Schneider, Pauline, Kerstjens, Mark, Molenaar, Jan J, Pieters, Rob, Zwaan, Christian Michel, Stam, Ronald W

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Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma von Van Renterghem, Britt, Wozniak, Agnieszka, Castro, Patricia Garrido, Franken, Patrick, Pencheva, Nora, Sciot, Raf, Schöffski, Patrick

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Trametinib inhibits RAS -mutant MLL -rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo von Kerstjens, Mark, Pinhancos, Sandra S, Castro, Patricia Garrido, Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W

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Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems von Rothdiener, Miriam, Müller, Dafne, Castro, Patricia Garrido, Scholz, Anja, Schwemmlein, Michael, Fey, Georg, Heidenreich, Olaf, Kontermann, Roland E.

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Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia von Verbeek, Tamara C. A. I., Vrenken, Kirsten S., Arentsen-Peters, Susan T. C. J. M., Castro, Patricia Garrido, van de Ven, Marieke, van Tellingen, Olaf, Pieters, Rob, Stam, Ronald W.

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High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia von Wander, Priscilla, Arentsen-Peters, Susan T.C.J.M., Pinhanҫos, Sandra S., Koopmans, Bianca, Dolman, M.Emmy M., Ariese, Rijndert, Bos, Frank L., Castro, Patricia Garrido, Jones, Luke, Schneider, Pauline, Navarro, Miriam Guillen, Molenaar, Jan J., Rios, Anne C., Zwaan, C. Michel, Stam, Ronald W.

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Glucocorticoid sensitisation in Mixed Lineage Leukaemia -rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101 von Spijkers-Hagelstein, Jill A.P, Schneider, Pauline, Pinhanços, Sandra Mimoso, Garrido Castro, Patricia, Pieters, Rob, Stam, Ronald W

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Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia von van der Linden, Marieke H, Seslija, Lidija, Schneider, Pauline, Driessen, Emma M C, Castro, Patricia Garrido, Stumpel, Dominique J P M, van Roon, Eddy, de Boer, Jasper, Williams, Owen, Pieters, Rob, Stam, Ronald W

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Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer von Schneider, Pauline, Castro, Patricia Garrido, Pinhanços, Sandra M., Kerstjens, Mark, Roon, Eddy H., Essing, Anke H.W., Dolman, M. Emmy M., Molenaar, Jan J., Pieters, Rob, Stam, Ronald W.

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Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma von Van Renterghem, Britt, Wozniak, Agnieszka, Castro, Patricia Garrido, Franken, Patrick, Pencheva, Nora, Sciot, Raf, Schoffski, Patrick

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Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade von Boshuizen, Julia, Pencheva, Nora, Krijgsman, Oscar, Altimari, Daniela D'Empaire, Castro, Patricia Garrido, de Bruijn, Beaunelle, Ligtenberg, Maarten A, Gresnigt-Van den Heuvel, Elke, Vredevoogd, David W, Song, Ji-Ying, Visser, Nils, Apriamashvili, Georgi, Janmaat, Maarten L, Plantinga, Theo S, Franken, Patrick, Houtkamp, Mischa, Lingnau, Andreas, Jure-Kunkel, Maria, Peeper, Daniel S

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Selective Inhibition of Class II HDAC Isoforms 4 and 5 Provides a Promising Therapeutic Intervention for MLL-Rearranged Acute Lymphoblastic Leukemia in Infants von Verbeek, Tamara C.A.I., Arentsen-Peters, Susan, Garrido Castro, Patricia, Pinhancos, Sandra, Vrenken, Kirsten, Varela-Moreira, Aida, Dolman, M. Emmy, Koopmans, Bianca, Pieters, Rob, Stam, Ronald W.

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Single Cell Transcriptomics Predicts Relapse in Infants with Acute Lymphoblastic Leukemia von Candelli, Tito, Schneider, Pauline, Garrido Castro, Patricia, Jones, Luke A, Pieters, Rob, Margaritis, Thanasis, Stam, Ronald W., Holstege, Frank C.P.

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Irinotecan Induces Complete Remission in MLL -Rearranged Acute Lymphoblastic Leukemia Xenografts von Garrido Castro, Patricia, Kerstjens, Mark, Pinhanços, Sandra S, Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald

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Abstract 1925: High-throughput drug library screening identifies potent drugs and novel drug targets for high-risk acute leukemia in children von Wander, Priscilla, Pinhanços, Sandra S., Koopmans, Bianca, Dolman, M. Emmy M., Schneider, Pauline, Castro, Patricia Garrido, Jones, Luke, Arentsen-Peters, Susan T.C.J.M., Kerstjens, Mark, Molenaar, Jan, Caron, Huib N., Pieters, Rob, Zwaan, Michel C., Stam, Ronald W.

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Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia von Wander, Priscilla, Cheung, Laurence C., Pinhanҫos, Sandra S., Jones, Luke, Kerstjens, Mark, Arentsen-Peters, Susan T.C.J.M., Singh, Sajla, Chua, Grace-Alyssa, Castro, Patricia Garrido, Schneider, Pauline, Dolman, M. Emmy M., Koopmans, Bianca, Molenaar, Jan J., Pieters, Rob, Zwaan, C. Michel, Kotecha, Rishi S., Stam, Ronald W.

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High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia von Wander, Priscilla, Arentsen-Peters, Susan T C J M, Pinhanҫos, Sandra S, Koopmans, Bianca, Dolman, M Emmy M, Ariese, Rijndert, Bos, Frank L, Castro, Patricia Garrido, Jones, Luke, Schneider, Pauline, Navarro, Miriam Guillen, Molenaar, Jan J, Rios, Anne C, Zwaan, C Michel, Stam, Ronald W

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