Phase I dose‐escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia von Ottmann, Oliver G., Müller‐Tidow, Carsten, Krämer, Alwin, Schlenk, Richard F., Lübbert, Michael, Bug, Gesine, Krug, Utz, Bochtler, Tilmann, Voss, Florian, Taube, Tillmann, Liu, Dan, Garin‐Chesa, Pilar, Döhner, Hartmut

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Comprehensive analysis of the ErbB receptor family in pediatric nervous system tumors and rhabdomyosarcoma von Varlet, Pascale, Bouffet, Eric, Casanova, Michela, Giangaspero, Felice, Antonelli, Manila, Hargrave, Darren, Ladenstein, Ruth, Pearson, Andy, Hawkins, Cynthia, König, Fatima Barbara, Rüschoff, Josef, Schmauch, Christian, Bühnemann, Claudia, Garin‐Chesa, Pilar, Schweifer, Norbert, Uttenreuther‐Fischer, Martina, Gibson, Neil, Ittrich, Carina, Krämer, Nicole, Solca, Flavio, Stolze, Britta, Geoerger, Birgit

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The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy von Sanderson, Michael P, Hofmann, Marco H, Garin-Chesa, Pilar, Schweifer, Norbert, Wernitznig, Andreas, Fischer, Stefan, Jeschko, Astrid, Meyer, Reiner, Moll, Jürgen, Pecina, Thomas, Arnhof, Heribert, Weyer-Czernilofsky, Ulrike, Zahn, Stephan K, Adolf, Günther R, Kraut, Norbert

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors von Schütte, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildiriman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans- Jörg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schäfer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure

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Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases von Hilberg, Frank, Tontsch-Grunt, Ulrike, Baum, Anke, Le, Anh T., Doebele, Robert C., Lieb, Simone, Gianni, Davide, Voss, Tilman, Garin-Chesa, Pilar, Haslinger, Christian, Kraut, Norbert

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hGPR87 contributes to viability of human tumor cells von Glatt, Sebastian, Halbauer, Daniel, Heindl, Stefan, Wernitznig, Andreas, Kozina, Daniela, Su, Kuan‐Chung, Puri, Christina, Garin‐Chesa, Pilar, Sommergruber, Wolfgang

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BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity von RUDOLPH, Dorothea, STEEGMAIER, Martin, HOFFMANN, Matthias, GRAUERT, Matthias, BAUM, Anke, QUANT, Jens, HASLINGER, Christian, GARIN-CHESA, Pilar, ADOLF, Gunther R

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BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo von Steegmaier, Martin, Hoffmann, Matthias, Baum, Anke, Lénárt, Péter, Petronczki, Mark, Krššák, Martin, Gürtler, Ulrich, Garin-Chesa, Pilar, Lieb, Simone, Quant, Jens, Grauert, Matthias, Adolf, Günther R., Kraut, Norbert, Peters, Jan-Michael, Rettig, Wolfgang J.

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Volasertib Versus Chemotherapy in Platinum-Resistant or -Refractory Ovarian Cancer: A Randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire S... von Pujade-Lauraine, Eric, Selle, Frédéric, Weber, Béatrice, Ray-Coquard, Isabelle-Laure, Vergote, Ignace, Sufliarsky, Jozef, Del Campo, Josep Maria, Lortholary, Alain, Lesoin, Anne, Follana, Philippe, Freyer, Gilles, Pardo, Beatriz, Vidal, Laura, Tholander, Bengt, Gladieff, Laurence, Sassi, Mouna, Garin-Chesa, Pilar, Nazabadioko, Serge, Marzin, Kristell, Pilz, Korinna, Joly, Florence

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Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts von Ostermann, Elinborg, Garin-Chesa, Pilar, Heider, Karl Heinz, Kalat, Milena, Lamche, Herbert, Puri, Christina, Kerjaschki, Dontscho, Rettig, Wolfgang J., Adolf, Guenther R.

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Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia von Rudolph, Dorothea, Impagnatiello, Maria Antonietta, Blaukopf, Claudia, Sommer, Christoph, Gerlich, Daniel W., Roth, Mareike, Tontsch-Grunt, Ulrike, Wernitznig, Andreas, Savarese, Fabio, Hofmann, Marco H., Albrecht, Christoph, Geiselmann, Lena, Reschke, Markus, Garin-Chesa, Pilar, Zuber, Johannes, Moll, Jürgen, Adolf, Günther R., Kraut, Norbert

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Expression of stromal cell markers in distinct compartments of human skin cancers von Huber, Margit A., Kraut, Norbert, Schweifer, Norbert, Dolznig, Helmut, Peter, Ralf U., Schubert, Roland D., Scharffetter-Kochanek, Karin, Pehamberger, Hubert, Garin-Chesa, Pilar

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A randomized, open‐label, phase I/II trial to investigate the maximum tolerated dose of the Polo‐like kinase inhibitor BI 2536 in elderly patients with refractory/relapsed acute my... von Müller‐Tidow, Carsten, Bug, Gesine, Lübbert, Michael, Krämer, Alwin, Krauter, Jürgen, Valent, Peter, Nachbaur, David, Berdel, Wolfgang E., Ottmann, Oliver G., Fritsch, Holger, Munzert, Gerd, Garin‐Chesa, Pilar, Fleischer, Frank, Taube, Tillmann, Döhner, Hartmut

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Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype von Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.

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A highly selective telomerase inhibitor limiting human cancer cell proliferation von Damm, Klaus, Hemmann, Ulrike, Garin-Chesa, Pilar, Hauel, Norbert, Kauffmann, Iris, Priepke, Henning, Niestroj, Claudia, Daiber, Christine, Enenkel, Barbara, Guilliard, Bernd, Lauritsch, Ines, Müller, Elfriede, Pascolo, Emanuelle, Sauter, Gabriele, Pantic, Milena, Martens, Uwe M., Wenz, Christian, Lingner, Joachim, Kraut, Norbert, Rettig, Wolfgang J., Schnapp, Andreas

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Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts von Park, J E, Lenter, M C, Zimmermann, R N, Garin-Chesa, P, Old, L J, Rettig, W J

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Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate von Pascolo, Emanuelle, Wenz, Christian, Lingner, Joachim, Hauel, Norbert, Priepke, Henning, Kauffmann, Iris, Garin-Chesa, Pilar, Rettig, Wolfgang J., Damm, Klaus, Schnapp, Andreas

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Molecular characterization of the desmoplastic tumor stroma in medullary thyroid carcinoma von KOPEREK, Oskar, SCHEUBA, Christian, PURI, Christina, BIRNER, Peter, HASLINGER, Christian, RETTIG, Wolfgang, NIEDERLE, Bruno, KASERER, Klaus, GARIN CHESAI, Pilar

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Fibroblast Activation Protein: Differential Expression and Serine Protease Activity in Reactive Stromal Fibroblasts of Melanocytic Skin Tumors von Huber, Margit A., Schubert, Roland D., Peter, Ralf U., Kraut, Norbert, Park, John E., Rettig, Wolfgang J., Garin-Chesa, Pilar

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FAPα, a surface peptidase expressed during wound healing, is a tumor suppressor von Ramirez-Montagut, Teresa, Blachere, Nathalie E, Sviderskaya, Elena V, Bennett, Dorothy C, Rettig, Wolfgang J, Garin-Chesa, Pilar, Houghton, Alan N

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