Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia von Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal von Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J. H. F., Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L., Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia von Baran, Natalia, Lodi, Alessia, Dhungana, Yogesh, Herbrich, Shelley, Collins, Meghan, Sweeney, Shannon, Pandey, Renu, Skwarska, Anna, Patel, Shraddha, Tremblay, Mathieu, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Kaplan, Mecit, Warmoes, Marc O., Veiga, Diogo Troggian, Furudate, Ken, Rojas-Sutterin, Shanti, Haman, Andre, Gareau, Yves, Marinier, Anne, Ma, Helen, Harutyunyan, Karine, Daher, May, Garcia, Luciana Melo, Al-Atrash, Gheath, Piya, Sujan, Ruvolo, Vivian, Yang, Wentao, Shanmugavelandy, Sriram Saravanan, Feng, Ningping, Gay, Jason, Du, Di, Yang, Jun J., Hoff, Fieke W., Kaminski, Marcin, Tomczak, Katarzyna, Eric Davis, R., Herranz, Daniel, Ferrando, Adolfo, Jabbour, Elias J., Emilia Di Francesco, M., Teachey, David T., Horton, Terzah M., Kornblau, Steven, Rezvani, Katayoun, Sauvageau, Guy, Gagea, Mihai, Andreeff, Michael, Takahashi, Koichi, Marszalek, Joseph R., Lorenzi, Philip L., Yu, Jiyang, Tiziani, Stefano, Hoang, Trang, Konopleva, Marina

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The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs von Abramovitz, Mark, Adam, Mohammed, Boie, Yves, Carrière, Marie-Claude, Denis, Danielle, Godbout, Claude, Lamontagne, Sonia, Rochette, Chantal, Sawyer, Nicole, Tremblay, Nathalie M, Belley, Michel, Gallant, Michel, Dufresne, Claude, Gareau, Yves, Ruel, Rejean, Juteau, Helene, Labelle, Marc, Ouimet, Nathalie, Metters, Kathleen M

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The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor von Ducharme, Yves, Blouin, Marc, Brideau, Christine, Châteauneuf, Anne, Gareau, Yves, Grimm, Erich L, Juteau, Hélène, Laliberté, Sébastien, MacKay, Bruce, Massé, Frédéric, Ouellet, Marc, Salem, Myriam, Styhler, Angela, Friesen, Richard W

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886 von RIENDEAU, Denis, ASPIOTIS, Renee, RUBIN, Joel, FRIESEN, Richard W, ETHIER, Diane, GAREAU, Yves, GRIMM, Erich L, GUAY, Jocelyne, GUIRAL, Sébastien, JUTEAU, Hélène, MANCINI, Joseph A, METHOT, Nathalie

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis von Nicholson, Donald W, Ali, Ambereen, Thornberry, Nancy A, Vaillancourt, John P, Ding, Connie K, Gallant, Michel, Gareau, Yves, Griffin, Patrick R, Labelle, Marc, Lazebnik, Yuri A, Munday, Neil A, Raju, Sayyaparaju M, Smulson, Mark E, Yamin, Ting-Ting, Yu, Violeta L, Miller, Douglas K

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Maintenance of Caspase-3 Proenzyme Dormancy by an Intrinsic "Safety Catch" Regulatory Tripeptide von Roy, Sophie, Bayly, Christopher I., Gareau, Yves, Houtzager, Vicky M., Kargman, Stacia, Sabina L. C. Keen, Rowland, Kathleen, Seiden, Isolde M., Thornberry, Nancy A., Nicholson, Donald W.

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Oxidation of aromatic and aliphatic triisopropylsilanylsulfanyls to sulfonyl chlorides: preparation of sulfonamides von Gareau, Yves, Pellicelli, Jonathan, Laliberté, Sébastien, Gauvreau, Danny

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1023 – THE IMPORTANCE OF STEM CELL EXPANSION IN TOMORROW'S MEDICINE von Sauvageau, Guy, Chagraoui, Jalila, Tomellini, Elisa, Rojas-Sutterlin, Shanti, Corneau, Sophie, Girard, Simon, Tellelchea, Maria Florencia, Gingras, Stephane, Gareau, Yves, Ruel, Rejean, Cohen, Sandra, Milano, Filippo, Marinier, Anne

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Preparation and reactivity studies of 1,2-bis-triisopropylsilanylsulfanyl-alkenes von Gareau, Yves, Tremblay, Mélanie, Gauvreau, Danny, Juteau, Hélène

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Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen von Pelletier, Benoit, Duhamel, Stéphanie, Tambutet, Guillaume, Jarvis, Scott, Cléroux, Patrick, David, Maud, Tanguay, Pierre-Luc, Voisin, Laure, James, Clint, Lavoie, Rico, Gareau, Yves, Flynn-Robitaille, Joël, Lorca, Thierry, Ruel, Réjean, Marinier, Anne, Meloche, Sylvain

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis von Rotonda, Jennifer, Nicholson, Donald W, Fazil, Kimberly M, Gallant, Michel, Gareau, Yves, Labelle, Marc, Peterson, Erin P, Rasper, Dita M, Ruel, Réjean, Vaillancourt, John P, Thornberry, Nancy A, Becker, Joseph W

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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia von Baccelli, Irene, Gareau, Yves, Lehnertz, Bernhard, Stephane, Gingras, Spinella, Jean-Francois, Beautrait, Alexandre, Corneau, Sophie, Mayotte, Nadine, Boivin, Isabel, Girard, Simon, MacRae, Tara, Frechette, Melanie, Leveille, Koryne, Krosl, Jana, Thiollier, Clarisse, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P, Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

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Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry von JUTEAU, Hélène, GAREAU, Yves, LABELLE, Marc, LAMONTAGNE, Sonia, TREMBLAY, Nathalie, CARRIERE, Marie-Claude, SAWYER, Nicole, DENIS, Danielle, METTERS, Kathleen M

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Inhibitors of the inducible microsomal prostaglandin E 2 synthase (mPGES-1) derived from MK-886 von Riendeau, Denis, Aspiotis, Renee, Ethier, Diane, Gareau, Yves, Grimm, Erich L., Guay, Jocelyne, Guiral, Sébastien, Juteau, Hélène, Mancini, Joseph A., Méthot, Nathalie, Rubin, Joel, Friesen, Richard W.

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Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition von Moison, Céline, Lavallée, Vincent-Philippe, Thiollier, Clarisse, Lehnertz, Bernhard, Boivin, Isabel, Mayotte, Nadine, Gareau, Yves, Fréchette, Mélanie, Blouin-Chagnon, Valérie, Corneau, Sophie, Lavallée, Sylvie, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

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identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y von Gauthier, Jacques Yves, Belley, Michel, Deschênes, Denis, Fournier, Jean-François, Gagné, Sébastien, Gareau, Yves, Hamel, Martine, Hénault, Martin, Hyjazie, Huda, Kargman, Stacia, Lavallée, Geneviève, Levesque, Jean-François, Li, Lianhai, Mamane, Yaël, Mancini, Joseph, Morin, Nicolas, Mulrooney, Erin, Robichaud, Joël, Thérien, Michel, Tranmer, Geoffrey, Wang, Zhaoyin, Wu, Jin, Black, W. Cameron

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14 von YVES GAUTHIER, Jacques, BELLEY, Michel, LAVALLEE, Geneviève, LEVESQUE, Jean-François, LIANHAI LI, MAMANE, Yael, MANCINI, Joseph, MORIN, Nicolas, MULROONEY, Erin, ROBICHAUD, Joel, THERIEN, Michel, TRANMER, Geoffrey, DESCHENES, Denis, ZHAOYIN WANG, JIN WU, BLACK, W. Cameron, FOURNIER, Jean-François, GAGNE, Sébastien, GAREAU, Yves, HAMEL, Martine, HENAULT, Martin, HYJAZIE, Huda, KARGMAN, Stacia

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Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal von Fares, Iman, Chagaroui, Jalila, Gareau, Yves, Gingras, Stéphane, Mayotte, Nadine, Csaszar, Elizabeth, Kiem, Hans-Peter, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

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