Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site von Kumar, Amit, Mao, Shenlan, Dimasi, Nazzareno, Gao, Changshou

Volltext

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy von Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Hinrichs, Mary Jane Masson, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

Volltext

A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery von Miyazaki, Takuya, Chen, Shaoyi, Florinas, Stelios, Igarashi, Kazunori, Matsumoto, Yu, Yamasoba, Tatsuya, Xu, Ze-Qi, Wu, Herren, Gao, Changshou, Kataoka, Kazunori, Christie, R. James, Cabral, Horacio

Volltext

Structural characterization of a human Fc fragment engineered for lack of effector functions von Oganesyan, Vaheh, Gao, Changshou, Shirinian, Lena, Wu, Herren, Dall'Acqua, William F.

Volltext

Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance von Zou, Jia, Li, Li, Zheng, Peiyi, Liang, Wenhua, Hu, Siyi, Zhou, Shuaixiang, Wang, Yanqun, Zhao, Jincun, Yuan, Daopeng, Liu, Lu, Wu, Dongdong, Xu, Mengqiu, Zhang, Fangfang, Zhu, Mengzhu, Wu, Zhihai, Cao, Xiaochao, Ni, Meng, Ling, Xiaomin, Wu, Yue, Kuang, Zhihui, Hu, Moyan, Li, Jianfeng, Li, Xue, Guo, Xiling, Xu, Tianmin, Jiang, Haiping, Gao, Changshou, Yu, Michael, Liu, Junjian, Zhong, Nanshan, Zhou, Jianfeng, Huang, Jian-An, Jin, Tengchuan, He, Jianxing

Volltext

A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments von Florinas, Stelios, Liu, Marc, Fleming, Ryan, Van Vlerken-Ysla, Lilian, Ayriss, Joanne, Gilbreth, Ryan, Dimasi, Nazzareno, Gao, Changshou, Wu, Herren, Xu, Ze-Qi, Chen, Shaoyi, Dirisala, Anjaneyulu, Kataoka, Kazunori, Cabral, Horacio, Christie, R. James

Volltext

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy von Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Masson Hinrichs, Mary Jane, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

Volltext

Hydrolytically Stable Site-Specific Conjugation at the N‑Terminus of an Engineered Antibody von Thompson, Pamela, Bezabeh, Binyam, Fleming, Ryan, Pruitt, Monica, Mao, Shenlan, Strout, Patrick, Chen, Cui, Cho, Song, Zhong, Haihong, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

Volltext

Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity von Chen, Shaoyi, Florinas, Stelios, Teitgen, Abigail, Xu, Ze-Qi, Gao, Changshou, Wu, Herren, Kataoka, Kazunori, Cabral, Horacio, Christie, R. James

Volltext

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways von Rios-Doria, Jonathan, Sabol, Darrin, Chesebrough, Jon, Stewart, Dave, Xu, Linda, Tammali, Ravinder, Cheng, Li, Du, Qun, Schifferli, Kevin, Rothstein, Ray, Leow, Ching Ching, Heidbrink-Thompson, Jenny, Jin, Xiaofang, Gao, Changshou, Friedman, Jay, Wilkinson, Brandy, Damschroder, Melissa, Pierce, Andrew J, Hollingsworth, Robert E, Tice, David A, Michelotti, Emil F

Volltext

Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production von Kurasawa, James H., Park, Andrew, Sowers, Carrie R., Halpin, Rebecca A., Tovchigrechko, Andrey, Dobson, Claire L., Schmelzer, Albert E., Gao, Changshou, Wilson, Susan D., Ikeda, Yasuhiro

Volltext

Molecular basis for the mechanism of action of an anti-TACE antibody von Peng, Li, Cook, Kimberly, Xu, Linda, Cheng, Li, Damschroder, Melissa, Gao, Changshou, Wu, Herren, Dall'Acqua, William F

Volltext

The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators von Dimasi, Nazzareno, Gao, Changshou, Fleming, Ryan, Woods, Robert M., Yao, Xiao-Tao, Shirinian, Lena, Kiener, Peter A., Wu, Herren

Volltext

Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice von Yusuf, Isharat, Stern, Jessica, McCaughtry, Tom M, Gallagher, Sandra, Sun, Hong, Gao, Changshou, Tedder, Thomas, Carlesso, Gianluca, Carter, Laura, Herbst, Ronald, Wang, Yue

Volltext

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format von Xiao, Xiaodong, Chen, Yan, Mugabe, Sheila, Gao, Changshou, Tkaczyk, Christine, Mazor, Yariv, Pavlik, Peter, Wu, Herren, Dall'Acqua, William, Chowdhury, Partha Sarathi

Volltext

The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics von Devanaboyina, Siva Charan, Lynch, Sandra M, Ober, Raimund J, Ram, Sripad, Kim, Dongyoung, Puig-Canto, Alberto, Breen, Shannon, Kasturirangan, Srinath, Fowler, Susan, Peng, Li, Zhong, Haihong, Jermutus, Lutz, Wu, Herren, Webster, Carl, Ward, E Sally, Gao, Changshou

Volltext

Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates von Thompson, Pamela, Ezeadi, Ebele, Hutchinson, Ian, Fleming, Ryan, Bezabeh, Binyam, Lin, Jia, Mao, Shenlan, Chen, Cui, Masterson, Luke, Zhong, Haihong, Toader, Dorin, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

Volltext

A mammalian expression system for high throughput antibody screening von Xu, Linda, Jin, Xiaofang, Rainey, G. Jonah, Wu, Herren, Gao, Changshou

Volltext

1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile von Kim, Han K, Monnier, Justin, Fu, Chi-Ling, Zhou, Matthew, Melrose, Jennifer E, Dao, Hung, Ponath, Paul D, McEachin, Katelynn A, Omstead, David T, Kreder, Cindy, Chun, Stefan, Lee, Ying Yueh, Grgich, Rachel, Lin, Tracey J, Walker, Joshua A, Henning, Karla A, Kudirka, Romas, Ackerman, Shelley E, Carrera, Diane, Chapin, Steven J, Mallet, William, Jackson, Dowdy, Gao, Changshou, Alonso, Michael N

Volltext

Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin von Mulgrew, Kathy, Kinneer, Krista, Yao, Xiao-Tao, Ward, Beth K., Damschroder, Melissa M., Walsh, Bill, Mao, Su-Yau, Gao, Changshou, Kiener, Peter A., Coats, Steve, Kinch, Michael S., Tice, David A.

Volltext