Beyond Recycling Antibodies: Crovalimab's Molecular Design Enables Four-Weekly Subcutaneous Injections for PNH Treatment von Sampei, Zenjiro, Haraya, Kenta, Gan, Siok Wan, Muraoka, Masaru, Hayasaka, Akira, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Tsuboi, Yoshinori, Gotoh, Akihiko, Obara, Naoshi, Ueda, Yasutaka

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The Small Hydrophobic Protein of the Human Respiratory Syncytial Virus Forms Pentameric Ion Channels von Gan, Siok-Wan, Tan, Edward, Lin, Xin, Yu, Dejie, Wang, Juejin, Tan, Gregory Ming-Yeong, Vararattanavech, Ardcharaporn, Yeo, Chiew Ying, Soon, Cin Huang, Soong, Tuck Wah, Pervushin, Konstantin, Torres, Jaume

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody von Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

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Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases von Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

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Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease von Okura, Yuu, Ikawa-Teranishi, Yuri, Mizoroki, Akihiko, Takahashi, Noriyuki, Tsushima, Takashi, Irie, Machiko, Harfuddin, Zulkarnain, Miura-Okuda, Momoko, Ito, Shunsuke, Nakamura, Genki, Takesue, Hiroaki, Ozono, Yui, Nishihara, Masamichi, Yamada, Kenta, Gan, Siok Wan, Hayasaka, Akira, Ishii, Shinya, Wakabayashi, Tetsuya, Muraoka, Masaru, Nagaya, Nishiki, Hino, Hiroshi, Nemoto, Takayuki, Kuramochi, Taichi, Torizawa, Takuya, Shimada, Hideaki, Kitazawa, Takehisa, Okazaki, Makoto, Nezu, Junichi, Sollid, Ludvig M., Igawa, Tomoyuki

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Two different conformations in hepatitis C virus p7 protein account for proton transport and dye release von Gan, Siok Wan, Surya, Wahyu, Vararattanavech, Ardcharaporn, Torres, Jaume

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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering von Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki

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Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants von Kuramochi, Taichi, Gan, Siok Wan, Ho, Adrian W S, Wang, Bei, Kageji, Nagisa, Nambu, Takeru, Iida, Sayaka, Okuda-Miura, Momoko, Chia, Wei Shan, Yeo, Chiew Ying, Chen, Dan, Lee, Wen-Hsin, Ngoh, Eve Zi Xian, Mohd Salleh, Siti Nazihah, Wang, Cheng-I, Igawa, Tomoyuki, Shimada, Hideaki

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Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement von Sampei, Zenjiro, Koo, Christine Xing'er, Teo, Frannie Jiuyi, Toh, Ying Xiu, Fukuzawa, Taku, Gan, Siok Wan, Nambu, Takeru, Ho, Adrian, Honda, Kiyofumi, Igawa, Tomoyuki, Ahmed, Fariyal, Wang, Cheng-I, Fink, Katja, Nezu, Junichi

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The transmembrane homotrimer of ADAM 1 in model lipid bilayers von Gan, Siok Wan, Xin, Lin, Torres, Jaume

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Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells von Vavassori, Stefano, Kumar, Anil, Wan, Gan Siok, Ramanjaneyulu, Gundimeda S, Cavallari, Marco, El Daker, Sary, Beddoe, Travis, Theodossis, Alex, Williams, Neal K, Gostick, Emma, Price, David A, Soudamini, Dinish U, Voon, Kong Kien, Olivo, Malini, Rossjohn, Jamie, Mori, Lucia, De Libero, Gennaro

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SKY59: A Long-Lasting Engineered Anti-C5 Antibody for Subcutaneously Injectable Anti-Complement Therapy von Haraya, Kenta, Sampei, Zenjiro, Tachibana, Tatsuhiko, Fukuzawa, Taku, Gan, Siok Wan, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Muraoka, Masaru, Igawa, Tomoyuki, Kitazawa, Takehisa, Nezu, Junichi

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Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain von Gan, Siok Wan, Ng, Lifang, Lin, Xin, Gong, Xiandi, Torres, Jaume

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A cost-effective method for simultaneous homo-oligomeric size determination and monodispersity conditions for membrane proteins von Gan, Siok Wan, Vararattanavech, Ardcharaporn, Nordin, Nurhuda, Eshaghi, Said, Torres, Jaume

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Abstract 1872: A DLL3/CD3/CD137 trispecific T cell engager shows potent antitumor activity in small cell lung cancer models von Mikami, Hirofumi, Feng, Shu, Naoi, Sotaro, Azuma, Yumiko, Kayukawa, Yoko, Tsunenari, Toshiaki, Asanuma, Kentaro, Iwabuchi, Ryutaro, Nagano, Hiroaki, Shinozuka, Junko, Yamazaki, Masaki, Kuroi, Haruka, Gan, Siok Wan, Chichili, Priyanka, Shimizu, Shun, Matsuda, Yutaka, Ishii, Shinya, Kamikawaji, Shogo, Kinoshita, Yasuko, Shimizu, Yuichiro, Sakamoto, Akihisa, Muraoka, Masaru, Takahashi, Noriyuki, Kawa, Tatsuya, Shiraiwa, Hirotake, Kashima, Kenji, Mimoto, Futa, Kamata-Sakurai, Mika, Kitazawa, Takehisa, Igawa, Tomoyuki

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Butyrophilin 3A1 binds phosphorylated antigens and stimulates human [gamma][delta] T cells von Vavassori, Stefano, Kumar, Anil, Wan, Gan Siok, Ramanjaneyulu, Gundimeda S, Cavallari, Marco, El Daker, Sary, Beddoe, Travis, Theodossis, Alex, Williams, Neal K, Gostick, Emma, Price, David A, Soudamini, Dinish U, Voon, Kong Kien, Olivo, Malini, Rossjohn, Jamie, Mori, Lucia, De Libero, Gennaro

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Two Different Conformations in Hepatitis C Virus p7 Protein Account for Proton Transport and Dye Release: e78494 von Gan, Siok Wan, Surya, Wahyu, Vararattanavech, Ardcharaporn, Torres, Jaume

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IMMUNE ACTIVATING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF von GAN Siok Wan, NAOI, Sotaro, FENG, Shu

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IMMUNE ACTIVATING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF von Naoi, Sotaro, Gan, Siok Wan, Feng, Shu

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IMMUNE ACTIVATING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF von GAN Siok Wan, NAOI, Sotaro, FENG, Shu

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