Distinct routes of lineage development reshape the human blood hierarchy across ontogeny von Notta, Faiyaz, Zandi, Sasan, Takayama, Naoya, Dobson, Stephanie, Gan, Olga I., Wilson, Gavin, Kaufmann, Kerstin B., McLeod, Jessica, Laurenti, Elisa, Dunant, Cyrille F., McPherson, John D., Stein, Lincoln D., Dror, Yigal, Dick, John E.

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Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer von Kreso, Antonija, O'Brien, Catherine A., van Galen, Peter, Gan, Olga I., Notta, Faiyaz, Brown, Andrew M. K., Ng, Karen, Ma, Jing, Wienholds, Erno, Dunant, Cyrille, Pollett, Aaron, Gallinger, Steven, McPherson, John, Mullighan, Charles G., Shibata, Darryl, Dick, John E.

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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization von Takayama, Naoya, Murison, Alex, Takayanagi, Shin-ichiro, Arlidge, Christopher, Zhou, Stanley, Garcia-Prat, Laura, Chan-Seng-Yue, Michelle, Zandi, Sasan, Gan, Olga I., Boutzen, Héléna, Kaufmann, Kerstin B., Trotman-Grant, Aaron, Schoof, Erwin, Kron, Ken, Díaz, Noelia, Lee, John J.Y., Medina, Tiago, De Carvalho, Daniel D., Taylor, Michael D., Vaquerizas, Juan M., Xie, Stephanie Z., Dick, John E., Lupien, Mathieu

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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal von Xie, Stephanie Z., Garcia-Prat, Laura, Voisin, Veronique, Ferrari, Robin, Gan, Olga I., Wagenblast, Elvin, Kaufmann, Kerstin B., Zeng, Andy G.X., Takayanagi, Shin-ichiro, Patel, Ishita, Lee, Esther K., Jargstorf, Joseph, Holmes, Gareth, Romm, Guy, Pan, Kristele, Shoong, Michelle, Vedi, Aditi, Luberto, Chiara, Minden, Mark D., Bader, Gary D., Laurenti, Elisa, Dick, John E.

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Mapping the cellular origin and early evolution of leukemia in Down syndrome von Wagenblast, Elvin, Araújo, Joana, Gan, Olga I, Cutting, Sarah K, Murison, Alex, Krivdova, Gabriela, Azkanaz, Maria, McLeod, Jessica L, Smith, Sabrina A, Gratton, Blaise A, Marhon, Sajid A, Gabra, Martino, Medeiros, Jessie J F, Manteghi, Sanaz, Chen, Jian, Chan-Seng-Yue, Michelle, Garcia-Prat, Laura, Salmena, Leonardo, De Carvalho, Daniel D, Abelson, Sagi, Abdelhaleem, Mohamed, Chong, Karen, Roifman, Maian, Shannon, Patrick, Wang, Jean C Y, Hitzler, Johann K, Chitayat, David, Dick, John E, Lechman, Eric R

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A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal von Milyavsky, Michael, Gan, Olga I., Trottier, Magan, Komosa, Martin, Tabach, Ofer, Notta, Faiyaz, Lechman, Eric, Hermans, Karin G., Eppert, Kolja, Konovalova, Zhanna, Ornatsky, Olga, Domany, Eytan, Meyn, M. Stephen, Dick, John E.

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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia von Kim, Jaeseung C., Chan-Seng-Yue, Michelle, Ge, Sabrina, Zeng, Andy G. X., Ng, Karen, Gan, Olga I., Garcia-Prat, Laura, Flores-Figueroa, Eugenia, Woo, Tristan, Zhang, Amy Xin Wei, Arruda, Andrea, Chithambaram, Shivapriya, Dobson, Stephanie M., Khoo, Amanda, Khan, Shahbaz, Ibrahimova, Narmin, George, Ann, Tierens, Anne, Hitzler, Johann, Kislinger, Thomas, Dick, John E., McPherson, John D., Minden, Mark D., Notta, Faiyaz

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Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells von Wagenblast, Elvin, Azkanaz, Maria, Smith, Sabrina A., Shakib, Lorien, McLeod, Jessica L., Krivdova, Gabriela, Araújo, Joana, Shultz, Leonard D., Gan, Olga I., Dick, John E., Lechman, Eric R.

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Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells von Mortin-Toth, Steven M, Takenaka, Katsuto, Gan, Olga I, Danska, Jayne S, Prasolava, Tatiana K, Dick, John E, Wang, Jean C Y, Khalouei, Sam

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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation von Xie, Stephanie Z, Kaufmann, Kerstin B, Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I, Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-Ichiro, Ng, Stanley W K, Xu, ChangJiang, Zeng, Andy G X, Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A, Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D, Wang, Jean C Y, Hannun, Yusuf A, Luberto, Chiara, Schroeder, Timm, Minden, Mark D, Dick, John E

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Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells von Dick, John E, Mazurier, Frédéric, Doedens, Monica, Gan, Olga I

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Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML von Krivdova, Gabriela, Voisin, Veronique, Schoof, Erwin M., Marhon, Sajid A., Murison, Alex, McLeod, Jessica L., Gabra, Martino M., Zeng, Andy G.X., Aigner, Stefan, Yee, Brian A., Shishkin, Alexander A., Van Nostrand, Eric L., Hermans, Karin G., Trotman-Grant, Aaron C., Mbong, Nathan, Kennedy, James A., Gan, Olga I., Wagenblast, Elvin, De Carvalho, Daniel D., Salmena, Leonardo, Minden, Mark D., Bader, Gary D., Yeo, Gene W., Dick, John E., Lechman, Eric R.

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TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate von García-Prat, Laura, Kaufmann, Kerstin B., Schneiter, Florin, Voisin, Veronique, Murison, Alex, Chen, Jocelyn, Chan-Seng-Yue, Michelle, Gan, Olga I., McLeod, Jessica L., Smith, Sabrina A., Shoong, Michelle C., Parris, Darrien, Pan, Kristele, Zeng, Andy G.X., Krivdova, Gabriela, Gupta, Kinam, Takayanagi, Shin-Ichiro, Wagenblast, Elvin, Wang, Weijia, Lupien, Mathieu, Schroeder, Timm, Xie, Stephanie Z., Dick, John E.

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Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin−CD34+CD38− population von McKenzie, Joby L., Takenaka, Katsuto, Gan, Olga I., Doedens, Monica, Dick, John E.

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Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs von Dobson, Stephanie M, García-Prat, Laura, Vanner, Robert J, Wintersinger, Jeffrey, Waanders, Esmé, Gu, Zhaohui, McLeod, Jessica, Gan, Olga I, Grandal, Ildiko, Payne-Turner, Debbie, Edmonson, Michael N, Ma, Xiaotu, Fan, Yiping, Voisin, Veronique, Chan-Seng-Yue, Michelle, Xie, Stephanie Z, Hosseini, Mohsen, Abelson, Sagi, Gupta, Pankaj, Rusch, Michael, Shao, Ying, Olsen, Scott R, Neale, Geoffrey, Chan, Steven M, Bader, Gary, Easton, John, Guidos, Cynthia J, Danska, Jayne S, Zhang, Jinghui, Minden, Mark D, Morris, Quaid, Mullighan, Charles G, Dick, John E

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A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness von Kaufmann, Kerstin B., Zeng, Andy G. X., Coyaud, Etienne, Garcia-Prat, Laura, Papalexi, Efthymia, Murison, Alex, Laurent, Estelle M. N., Chan-Seng-Yue, Michelle, Gan, Olga I., Pan, Kristele, McLeod, Jessica, Boutzen, Héléna, Zandi, Sasan, Takayanagi, Shin-ichiro, Satija, Rahul, Raught, Brian, Xie, Stephanie Z., Dick, John E.

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KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition von Boila, Liberalis Debraj, Ghosh, Subhadeep, Bandyopadhyay, Subham K., Jin, Liqing, Murison, Alex, Zeng, Andy G. X., Shaikh, Wasim, Bhowmik, Satyaki, Muddineni, Siva Sai Naga Anurag, Biswas, Mayukh, Sinha, Sayantani, Chatterjee, Shankha Subhra, Mbong, Nathan, Gan, Olga I., Bose, Anwesha, Chakraborty, Sayan, Arruda, Andrea, Kennedy, James A., Mitchell, Amanda, Lechman, Eric R., Banerjee, Debasis, Milyavsky, Michael, Minden, Mark D., Dick, John E., Sengupta, Amitava

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An ERG Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation von Aqaqe, Nasma, Yassin, Muhammad, Yassin, Abed Alkader, Ershaid, Nour, Katz-Even, Chen, Zipin-Roitman, Adi, Kugler, Eitan, Lechman, Eric R, Gan, Olga I, Mitchell, Amanda, Dick, John E, Izraeli, Shai, Milyavsky, Michael

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Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment von Dick, John E, McKenzie, Joby L, Gan, Olga I, Doedens, Monica, Wang, Jean C Y

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Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors von Wojtowicz, Edyta E., Lechman, Eric R., Hermans, Karin G., Schoof, Erwin M., Wienholds, Erno, Isserlin, Ruth, van Veelen, Peter A., Broekhuis, Mathilde J.C., Janssen, George M.C., Trotman-Grant, Aaron, Dobson, Stephanie M., Krivdova, Gabriela, Elzinga, Jantje, Kennedy, James, Gan, Olga I., Sinha, Ankit, Ignatchenko, Vladimir, Kislinger, Thomas, Dethmers-Ausema, Bertien, Weersing, Ellen, Alemdehy, Mir Farshid, de Looper, Hans W.J., Bader, Gary D., Ritsema, Martha, Erkeland, Stefan J., Bystrykh, Leonid V., Dick, John E., de Haan, Gerald

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