Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD von Mathias, Sven, Wippermann, Anna, Raab, Nadja, Zeh, Nikolas, Handrick, René, Gorr, Ingo, Schulz, Patrick, Fischer, Simon, Gamer, Martin, Otte, Kerstin

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Polysaccharide Synthesis of the Levansucrase SacB from Bacillus megaterium Is Controlled by Distinct Surface Motifs von Strube, Christian P., Homann, Arne, Gamer, Martin, Jahn, Dieter, Seibel, Jürgen, Heinz, Dirk W.

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High-Yield Intra- and Extracellular Protein Production Using Bacillus megaterium von Stammen, Simon, Müller, Britta Katrin, Korneli, Claudia, Biedendieck, Rebekka, Gamer, Martin, Franco-Lara, Ezequiel, Jahn, Dieter

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Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20 von Pieper, Lisa A., Strotbek, Michaela, Wenger, Till, Gamer, Martin, Olayioye, Monilola A., Hausser, Angelika

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Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain von Bauer, Joschka, Mathias, Sven, Kube, Sebastian, Otte, Kerstin, Garidel, Patrick, Gamer, Martin, Blech, Michaela, Fischer, Simon, Karow-Zwick, Anne R

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High yield recombinant penicillin G amidase production and export into the growth medium using Bacillus megaterium von Yang, Yang, Biedendieck, Rebekka, Wang, Wei, Gamer, Martin, Malten, Marco, Jahn, Dieter, Deckwer, Wolf-Dieter

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A Bacillus megaterium Plasmid System for the Production, Export, and One-Step Purification of Affinity-Tagged Heterologous Levansucrase from Growth Medium von MALTEN, Marco, BIEDENDIECK, Rebekka, GAMER, Martin, DREWS, Ann-Christin, STAMMEN, Simon, BUCHHOLZ, Klaus, DIJKHUIZEN, Lubbert, JAHN, Dieter

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Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing von Stadermann, Anna, Gamer, Martin, Fieder, Jürgen, Lindner, Benjamin, Fehrmann, Steffen, Schmidt, Moritz, Schulz, Patrick, Gorr, Ingo H.

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miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line development von Fischer, Simon, Marquart, Kim F., Pieper, Lisa A., Fieder, Juergen, Gamer, Martin, Gorr, Ingo, Schulz, Patrick, Bradl, Harald

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A blueprint from nature: miRNome comparison of plasma cells and CHO cells to optimize therapeutic antibody production von Raab, Nadja, Zeh, Nikolas, Schlossbauer, Patrick, Mathias, Sven, Lindner, Benjamin, Stadermann, Anna, Gamer, Martin, Fischer, Simon, Holzmann, Karlheinz, Handrick, René, Otte, Kerstin

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Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy von Mathias, Sven, Fischer, Simon, Handrick, René, Fieder, Jürgen, Schulz, Patrick, Bradl, Harald, Gorr, Ingo, Gamer, Martin, Otte, Kerstin

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Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N‐glycolylneuraminic acid sialylation on monoclonal antibodies von Fischer, Simon, Mathias, Sven, Stadermann, Anna, Yang, Shumin, Schmieder, Valerie, Zeh, Nikolas, Schmidt, Nicoletta, Richter, Patrick, Wright, Sara, Zimmermann, Eike, Ley, Yan, Meer, Julia, Hartsch, Thomas, Bernloehr, Christian, Otte, Kerstin, Bradl, Harald, Gamer, Martin, Schulz, Patrick

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Impact of rare codons and the functional coproduction of rate-limiting tRNAs on recombinant protein production in Bacillus megaterium von Finger, Constanze, Gamer, Martin, Klunkelfuß, Saskia, Bunk, Boyke, Biedendieck, Rebekka

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T7 RNA polymerase-dependent gene expression system for Bacillus megaterium von Gamer, Martin, Fröde, David, Biedendieck, Rebekka, Stammen, Simon, Jahn, Dieter

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Looking for natural competence in Bacillus megaterium von Knuuti, Tobias, Gamer, Martin, Finger, Constanze, Biedendieck, Rebekka, Jahn, Dieter

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A sucrose-inducible promoter system for the intra- and extracellular protein production in Bacillus megaterium von Biedendieck, Rebekka, Gamer, Martin, Jaensch, Lothar, Meyer, Steffen, Rohde, Manfred, Deckwer, Wolf-Dieter, Jahn, Dieter

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Application of Escherichia coli phage K1E DNA-dependent RNA polymerase for in vitro RNA synthesis and in vivo protein production in Bacillus megaterium von Stammen, Simon, Schuller, Franziska, Dietrich, Sylvia, Gamer, Martin, Biedendieck, Rebekka, Jahn, Dieter

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Influence of codon usage on heterologous protein production in Bacillus megaterium von Finger, Constanze, Gamer, Martin, Bunk, Boyke, Knuuti, Tobias, Biedendieck, Rebekka, Jahn, Dieter

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Export, purification, and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium von Biedendieck, Rebekka, Beine, Rafael, Gamer, Martin, Jordan, Eva, Buchholz, Klaus, Seibel, Jürgen, Dijkhuizen, Lubbert, Malten, Marco, Jahn, Dieter

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Bacillus megaterium—An alternative expression system von Gamer, Martin, Stammen, Simon, Biedendieck, Rebekka, Fröde, David, Yang, Yang, Jahn, Dieter

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