An unusual example of hereditary multiple exostoses: a case report and review of the literature von Chilvers, Rebecca, Gallagher, James A, Jeffery, Nathan, Bond, Alistair P

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Nitisinone Treatment Affects Biomarkers of Bone and Cartilage Remodelling in Alkaptonuria Patients von Genovese, Federica, Frederiksen, Peder, Bay-Jensen, Anne-Christine, Karsdal, Morten A, Milan, Anna M, Olsson, Birgitta, Rudebeck, Mattias, Gallagher, James A, Ranganath, Lakshminarayan R

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Receptors and effects of gut hormones in three osteoblastic cell lines von Pacheco-Pantoja, Elda L, Ranganath, Lakshminarayan R, Gallagher, James A, Wilson, Peter J M, Fraser, William D

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Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism von Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM, Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.

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Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial von Ooi, Nicola, Cooper, Ian R, Norman, Brendan, Gallagher, James A, Sireau, Nick, Bou-Gharios, George, Ranganath, Lakshminarayan R, Savage, Victoria J

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Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria von Davison, Andrew S, Norman, Brendan P, Sutherland, Hazel, Milan, Anna M, Gallagher, James A, Jarvis, Jonathan C, Ranganath, Lakshminarayan R

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Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation... von Haaike, Colemonts-Vroninks, Brendan, Norman P., Sven, Van Laere, Andrew, Davison S., Lionel, Marcélis, Georges, Casimir, Philippe, Goyens, Paul, Claes, Dimitri, De Bundel, Geert, Martens, Rao, Ranganath Lakshminarayan, Tamara, Vanhaecke, James A, Gallagher, Joery, De Kock

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Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen... von Ranganath, Lakshminarayan R, Milan, Anna M, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A

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Increased prevalence of Parkinson's disease in alkaptonuria von Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.

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Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria von Ranganath, Lakshminarayan R, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A, Milan, Anna M

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Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling von Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard

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Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria von Norman, Brendan P, Davison, Andrew S, Hickton, Bryony, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Wilson, Peter J. M, Sutherland, Hazel, Hughes, Juliette H, Roberts, Norman B, Bou-Gharios, George, Gallagher, James A, Ranganath, Lakshminarayan R

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Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies von Braconi, Daniela, Geminiani, Michela, Psarelli, Eftychia Eirini, Giustarini, Daniela, Marzocchi, Barbara, Rossi, Ranieri, Bernardini, Giulia, Spiga, Ottavia, Gallagher, James A, Le Quan Sang, Kim-Hanh, Arnoux, Jean-Baptiste, Imrich, Richard, Al-Sbou, Mohammed S, Gornall, Matthew, Jackson, Richard, Ranganath, Lakshminarayan R, Santucci, Annalisa

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Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review von Ranganath, Lakshminarayan R., Norman, Brendan P., Gallagher, James A.

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Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2‐dioxygenase deficiency in the liver is responsible for homogentisic acid‐derived ochronotic pigme... von Wilson, Peter J. M., Ranganath, Lakshminarayan R., Bou‐Gharios, George, Gallagher, James A., Hughes, Juliette H.

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Recent advances in management of alkaptonuria (invited review; best practice article) von Ranganath, Lakshminarayan R, Jarvis, Jonathan C, Gallagher, James A

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Human Keratinocytes Release ATP and Utilize Three Mechanisms for Nucleotide Interconversion at the Cell Surface von Burrell, Helen E, Wlodarski, Brenda, Foster, Brian J, Buckley, Katherine A, Sharpe, Graham R, Quayle, John M, Simpson, Alec W M, Gallagher, James A

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Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre von Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Davison, Andrew S., Wilson, Peter J., Dillon, Jane P., West, Elizabeth, Gallagher, James A.

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Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage von Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut

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The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro von Agrawal, Ankita, Buckley, Katherine A., Bowers, Keith, Furber, Mark, Gallagher, James A., Gartland, Alison

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