RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) von Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Rosen, Neal, Solit, David B.

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Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon? von Shahar Gabay, Tal, Chapal-Ilani, Noa, Moskovitz, Yoni, Biezuner, Tamir, Oron, Barak, Brilon, Yardena, Fridman-Dror, Anna, Sabah, Rawan, Balicer, Ran, Tanay, Amos, Mendelson-Cohen, Netta, Dann, Eldad J, Fineman, Riva, Kaushansky, Nathali, Yehudai-Reshef, Shlomit, Zuckerman, Tsila, Shlush, Liran I

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Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon? von Shahar Gabay, Tal, Chapal-Ilani, Noa, Moskovitz, Yoni, Biezuner, Tamir, Oron, Barak, Brilon, Yardena, Fridman-Dror, Anna, Sabah, Rawan, Balicer, Ran, Tanay, Amos, Mendelson-Cohen, Netta, Dann, Eldad J, Fineman, Riva, Kaushansky, Nathali, Yehudai-Reshef, Shlomit, Zuckerman, Tsila, Shlush, Liran I

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Abnormal adipogenic signaling in the bone marrow mesenchymal stem cells contributes to supportive microenvironment for leukemia development von Sabbah, Rawan, Saadi, Sahar, Shahar-Gabay, Tal, Gerassy, Shiran, Yehudai-Resheff, Shlomit, Zuckerman, Tsila

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Changes in the Main Bone Marrow Cell Subpopulations May Potentially Contribute to the Initiation of Acute Myeloid Leukemia von Yehudai-Reshef, Shlomit, Sabah, Rawan, Gabay, Tal, Zuckerman, Tsila

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Unraveling at Diagnosis Chemoresistant Relapse-Initiating Clones in Acute Myeloid Leukemia: Combined Functional and Genomic Analyses Using Single-Cell-Derived Hematopoietic Stem an... von Zuckerman, Tsila, Gabay, Tal, Stolero, Nofar, Rabhun, Niv, Sabah, Rawan, Raz, Ofir, Neumeier, Yaara, Marx, Zipora, Tao, Liming, Biezuner, Tamir, Amir, Shiran, Adar, Rivka, Levy, Ron, Chapal Ilani, Noa, Shlush, Liran I., Shapiro, Ehud, Yehudai-Reshef, Shlomit

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Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells von Yehudai‐Resheff, Shlomit, Attias‐Turgeman, Shira, Sabbah, Rawan, Gabay, Tal, Musallam, Raneem, Fridman‐Dror, Anna, Zuckerman, Tsila

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Bone Marrow Stromal Cells Derived at Diagnosis and Remission Preferentially Support AML Cell Proliferation in Vitro von Yehudai-Reshef, Shlomit, Attias, Shira, Gabay, Tal, Sabah, Rawan, Zuckerman, Tsila

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Donor Cell Leukemia: The Role of Recipient Microenvironment von Yehudai-Reshef, Shlomit, Oron, Barak, Moskovitz, Yoni, Gabay, Tal, Fridman-Dror, Anna, Sabah, Rawan, Kaushansky, Nathali, Zuckerman, Tsila, Shlush, Liran I.

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The Contribution of Bone Marrow Stromal Cells to Leukemia Evolution: Differential Support of Leukemia Cell Growth at Diagnosis and Remission von Yehudai-Reshef, Shlomit, Attias, Shira, Gabay, Tal, Sabah, Rawan, Morgenstern, Yael, Zuckerman, Tsila

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Abstract 654: CD28 shedding is a novel resistance mechanism to anti PD-1 therapy von Hakim, Motti, Dror, Anna Fridman, Gabay, Tal Shahar, Alishekevitz, Dror, Meilin, Edna, Mandel, Ilana, Sapir, Yair, Shulman, Avidor, Moshe, Tehila Ben

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Abstract LB-419: An in-frame deletion in the N-terminal regulatory domain of BRAF(V600E) causes resistance to the RAF inhibitor PLX4032 von Poulikakos, Poulikos I., Persaud, Yogindra, Gabay, May Tal, Janakiraman, Manickam, Joseph, Eric W., Pratilas, Christine A., Chapman, Paul B., Rosen, Neal, Solit, David B.

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Abstract LB-428: RAS-independent dimerization of BRAF(V600E) splicing variants promotes resistance to RAF inhibitors von Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Rosen, Neal, Solit, David B.

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RAF inhibitor resistance ismediated by dimerization of aberrantly spliced BRAF(V600E) von Poulikakos, Poulikos I, Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B, Tadi, Madhavi, Wargo, Jennifer A, Flaherty, Keith T, Kelley, Mark C, Misteli, Tom, Chapman, Paul B, Sosman, Jeffrey A, Graeber, Thomas G, Ribas, Antoni, Lo, Roger S, Rosen, Neal, Solit, David B

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CD28 SHEDDING BLOCKING AGENTS von LEWKOWICZ, Ayala, HAKIM, Motti, FRIDMAN-DROR, Anna, CHEN ZELTSBURG, Lilach, MANDEL, Ilana, SAPIR, Yair, SHULMAN, Avidor, BEN-MOSHE, Tehila, GABAY, Tal

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CD28 SHEDDING BLOCKING AGENTS von LEWKOWICZ, Ayala, HAKIM, Motti, FRIDMAN-DROR, Anna, CHEN ZELTSBURG, Lilach, MANDEL, Ilana, SAPIR, Yair, SHULMAN, Avidor, BEN-MOSHE, Tehila, GABAY, Tal

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SOLUBLE CD28 LEVELS AFTER IMMUNOTHERAPY von HAKIM, Motti, ALISHEKEVITZ, Dror, FRIDMAN-DROR, Anna, SHILOVIZKY, Orit, MANDEL, Ilana, SAPIR, Yair, SHULMAN, Avidor, BEN-MOSHE, Tehila, GABAY, Tal

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Cd28 shedding blocking agents von MANDEL Ilana, GABAY Tal, BEN-MOSHE Tehila, SHULMAN Avidor, FRIDMAN-DROR Anna, SAPIR Yair, CHEN ZELTSBURG Lilach, HAKIM Motti, LEWKOWICZ Ayala

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CD28 SHEDDING BLOCKING AGENTS von LEWKOWICZ, Ayala, HAKIM, Motti, FRIDMAN-DROR, Anna, CHEN ZELTSBURG, Lilach, MANDEL, Ilana, SAPIR, Yair, SHULMAN, Avidor, BEN-MOSHE, Tehila, GABAY, Tal

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Hemoglobin Denaturation and Iron Release in Acidified Red Blood Cell Lysate-A Possible Source of Iron for Intraerythrocytic Malaria Parasites von Gabay, T., Ginsburg, H.

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