RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia von Jerchel, I S, Hoogkamer, A Q, Ariës, I M, Steeghs, E M P, Boer, J M, Besselink, N J M, Boeree, A, van de Ven, C, de Groot-Kruseman, H A, de Haas, V, Horstmann, M A, Escherich, G, Zwaan, C M, Cuppen, E, Koudijs, M J, Pieters, R, den Boer, M L

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EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion von Ariës, I M, Jerchel, I S, van den Dungen, R E S R, van den Berk, L C J, Boer, J M, Horstmann, M A, Escherich, G, Pieters, R, den Boer, M L

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Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97 von Escherich, G, Horstmann, M A, Zimmermann, M, Janka-Schaub, G E

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Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol von Driessen, E M C, de Lorenzo, P, Campbell, M, Felice, M, Ferster, A, Hann, I, Vora, A, Hovi, L, Escherich, G, Li, C K, Mann, G, Leblanc, T, Locatelli, F, Biondi, A, Rubnitz, J, Schrappe, M, Silverman, L, Stary, J, Suppiah, R, Szczepanski, T, Valsecchi, M, Pieters, R

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Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment von Eckert, C, Hagedorn, N, Sramkova, L, Mann, G, Panzer-Grümayer, R, Peters, C, Bourquin, J-P, Klingebiel, T, Borkhardt, A, Cario, G, Alten, J, Escherich, G, Astrahantseff, K, Seeger, K, Henze, G, von Stackelberg, A

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Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004 von Rasche, M, von Neuhoff, C, Dworzak, M, Bourquin, J-P, Bradtke, J, Göhring, G, Escherich, G, Fleischhack, G, Graf, N, Gruhn, B, Haas, O A, Klingebiel, T, Kremens, B, Lehrnbecher, T, von Stackelberg, A, Tchinda, J, Zemanova, Z, Thiede, C, von Neuhoff, N, Zimmermann, M, Creutzig, U, Reinhardt, D

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Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol von Driessen, E M C, de Lorenzo, P, Campbell, M, Felice, M, Ferster, A, Hann, I, Vora, A, Hovi, L, Escherich, G, Li, C K, Mann, G, Leblanc, T, Locatelli, F, Biondi, A, Rubnitz, J, Schrappe, M, Silverman, L, Stary, J, Suppiah, R, Szczepanski, T, Valsecchi, M, Pieters, R

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The long-term impact of in vitro drug sensitivity on risk stratification and treatment outcome in acute lymphoblastic leukemia of childhood (CoALL 06-97) von ESCHERICH, Gabriele, TRÖGER, Anja, PIETERS, Rob, DEN BOER, Monique L, HORSTMANN, Martin, JANKA, Gritta E, GÖBEL, Ulrich, GRAUBNER, Ulrike, PEKRUN, Arnulf, JORCH, Norbert, KASPERS, Gjl, ZIMMERMANN, Martin, ZUR STADT, Udo, KAZEMIER, Karin

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S108: PEDIATRIC T‐ ALL RELAPSE: CONSTITUTIONAL CANCER PREDISPOSITION AND HYPERMUTATATOR PHENOTYPES von Richter‐Pechanska, P., Kunz, J., Rausch, T., Erarslan‐Uysal, B., Bornhauser, B., Frismantas, V., Assenov, Y., Zimmermann, M., Happich, M., Knebel‐Doeberitz, C., Neuhoff, N., Koehler, R., Stanulla, M., Schrappe, M., Cario, G., Escherich, G., Kischner‐Schwabe, R., Eckert, C., Avigad, S., Pfister, S., Muckenthaler, M., Bourquin, J.‐P., Korbel, J., Kulozik, A.

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Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation von van der Sluis, Inge M, Vrooman, Lynda M, Pieters, Rob, Baruchel, Andre, Escherich, Gabriele, Goulden, Nicholas, Mondelaers, Veerle, Sanchez de Toledo, Jose, Rizzari, Carmelo, Silverman, Lewis B, Whitlock, James A

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Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium von Buchmann, Swantje, Schrappe, Martin, Baruchel, Andre, Biondi, Andrea, Borowitz, Michael, Campbell, Myriam, Cario, Gunnar, Cazzaniga, Giovanni, Escherich, Gabriele, Harrison, Christine J., Heyman, Mats, Hunger, Stephen P., Kiss, Csongor, Liu, Hsi-Che, Locatelli, Franco, Loh, Mignon L., Manabe, Atsushi, Mann, Georg, Pieters, Rob, Pui, Ching-Hon, Rives, Susana, Schmiegelow, Kjeld, Silverman, Lewis B., Stary, Jan, Vora, Ajay, Brown, Patrick

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No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study von Conter, Valentino, Valsecchi, Maria Grazia, De Lorenzo, Paola, Gandemer, Virginie, Heyman, Mats, Saha, Vaskar, Diaz, Paulina, Li, Chi-Kong, Attarbaschi, Andishe, Escherich, Gabriele, Stary, Jan, Schrappe, Martin, Pieters, Rob, Cario, Gunnar, Biondi, Andrea

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ETV6::RUNX1 Acute Lymphoblastic Leukemia: how much therapy is needed for cure? von Østergaard, Anna, Fiocco, Marta, de Groot-Kruseman, Hester, Moorman, Anthony V., Vora, Ajay, Zimmermann, Martin, Schrappe, Martin, Biondi, Andrea, Escherich, Gabriele, Stary, Jan, Imai, Chihaya, Imamura, Toshihiko, Heyman, Mats, Schmiegelow, Kjeld, Pieters, Rob

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Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study von Anastasopoulou, Stavroula, Swann, Gemma, Andres-Jensen, Liv, Attarbaschi, Andishe, Barzilai-Birenboim, Shlomit, Erdelyi, Daniel J, Escherich, Gabriele, Hamadeh, Lina, Harila, Arja, Lopez-Lopez, Elixabet, McGowan, Sheena, Möricke, Anja, Putti, Caterina, Sagi, Judit C, Schmiegelow, Kjeld, Ullrich, Nicole J, van der Sluis, Inge M, Wahid, Qurat-Ul-Ain, Winick, Naomi, Sramkova, Lucie, Zalcberg, Yair, Zapotocka, Ester, Bhojwani, Deepa, Halsey, Christina

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A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia von Enshaei, Amir, O'Connor, David, Bartram, Jack, Hancock, Jeremy, Harrison, Christine J., Hough, Rachael, Samarasinghe, Sujith, den Boer, Monique L., Boer, Judith M., de Groot-Kruseman, Hester A., Marquart, Hanne V., Noren-Nystrom, Ulrika, Schmiegelow, Kjeld, Schwab, Claire, Horstmann, Martin A., Escherich, Gabriele, Heyman, Mats, Pieters, Rob, Vora, Ajay, Moppett, John, Moorman, Anthony V.

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MOLECULAR GENETICS ANALYSIS OF B-CELL PRECURSOR LYMPHOMA IN PEDIATRIC AND ADOLESCENT PATIENTS REVEALS HIGH FREQUENCY OF KMT2A TRANSLOCATIONS von Iaccarino, I., Au-Yeung, R., Padilla, L., Zimmermann, M., Reinke, S., Oschlies, I., Escherich, G., Woessmann, W., Burkhardt, B., Klapper, W.

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052 - MOLECULAR GENETICS ANALYSIS OF B-CELL PRECURSOR LYMPHOMA IN PEDIATRIC AND ADOLESCENT PATIENTS REVEALS HIGH FREQUENCY OF KMT2A TRANSLOCATIONS von Iaccarino, I., Au-Yeung, R., Padilla, L., Zimmermann, M., Reinke, S., Oschlies, I., Escherich, G., Woessmann, W., Burkhardt, B., Klapper, W.

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New treatment strategies for children and adolescents with acute lymphoblastic leukemia von Cario, G., Escherich, G., Moricke, A., Alten, J., Schewe, D. M., Vieth, S., Stanulla, M., Zimmermann, M., Schrappe, M.

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Daunorubicin-Induced Cell Kill with 1-Hour Versus 24-Hour Infusions: A Randomized Comparison in Children with Newly Diagnosed Acute Lymphoblastic Leukemia von Escherich, G., Göbel, U., Jorch, N., Spaar, H. J., Janka-Schaub, G. E.

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The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia von Østergaard, Anna, Enshaei, Amir, Pieters, Rob, Vora, Ajay, Horstmann, Martin A., Escherich, Gabriele, Johansson, Bertil, Heyman, Mats, Schmiegelow, Kjeld, Hoogerbrugge, Peter M., Boer, Monique L., Kuiper, Roland P., Moorman, Anthony V., Boer, Judith M., Leeuwen, Frank N.

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