Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms von Zhang, Yixin, Toyoda, Futoshi, Himeno, Yukiko, Noma, Akinori, Amano, Akira

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Selective activation of adrenoceptors potentiates IKs current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways von Mi, Xinya, Ding, Wei-Guang, Toyoda, Futoshi, Kojima, Akiko, Omatsu-Kanbe, Mariko, Matsuura, Hiroshi

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Heterogeneous functional expression of the sustained inward Na+ current in guinea pig sinoatrial node cells von Toyoda, Futoshi, Wei-Guang, Ding, Matsuura, Hiroshi

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D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome von Nishio, Yukiko, MD, Makiyama, Takeru, MD, PhD, Itoh, Hideki, MD, PhD, Sakaguchi, Tomoko, MD, PhD, Ohno, Seiko, MD, PhD, Gong, Yin-Zhi, MD, PhD, Yamamoto, Satoshi, MD, Ozawa, Tomoya, MD, PhD, Ding, Wei-Guang, MD, PhD, Toyoda, Futoshi, PhD, Kawamura, Mihoko, MD, Akao, Masaharu, MD, PhD, Matsuura, Hiroshi, MD, PhD, Kimura, Takeshi, MD, PhD, Kita, Toru, MD, PhD, Horie, Minoru, MD, PhD

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Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes von Kohjitani, Hirohiko, Koda, Shigeya, Himeno, Yukiko, Makiyama, Takeru, Yamamoto, Yuta, Yoshinaga, Daisuke, Wuriyanghai, Yimin, Kashiwa, Asami, Toyoda, Futoshi, Zhang, Yixin, Amano, Akira, Noma, Akinori, Kimura, Takeshi

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Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly von Ozawa, Junichi, Ohno, Seiko, Melgari, Dario, Wang, Qi, Fukuyama, Megumi, Toyoda, Futoshi, Makiyama, Takeru, Yoshinaga, Masao, Suzuki, Hiroshi, Saitoh, Akihiko, Ai, Tomohiko, Horie, Minoru

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CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current von Toyoda, Futoshi, Mesirca, Pietro, Dubel, Stefan, Ding, Wei-Guang, Striessnig, Joerg, Mangoni, Matteo E., Matsuura, Hiroshi

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Expression and functional maintenance of volume-regulated anion channels in myometrial smooth muscles of pregnant mice von Yamada, Kazutaka, Ding, Wei-Guang, Omatsu-Kanbe, Mariko, Toyoda, Futoshi, Tsuji, Shunichiro, Katsura, Daisuke, Kimura, Fuminori, Matsuura, Hiroshi, Murakami, Takashi

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Editorial: Cardiac Pacemaking in Health and Disease: From Genes to Function von D’Souza, Alicia, Boink, Gerard J. J., Toyoda, Futoshi, Mesirca, Pietro

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Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy von Hayano, Mamoru, Makiyama, Takeru, Kamakura, Tsukasa, Watanabe, Hiroshi, Sasaki, Kenichi, Funakoshi, Shunsuke, Wuriyanghai, Yimin, Nishiuchi, Suguru, Harita, Takeshi, Yamamoto, Yuta, Kohjitani, Hirohiko, Hirose, Sayako, Yokoi, Fumika, Chen, Jiarong, Baba, Osamu, Horie, Takahiro, Chonabayashi, Kazuhisa, Ohno, Seiko, Toyoda, Futoshi, Yoshida, Yoshinori, Ono, Koh, Horie, Minoru, Kimura, Takeshi

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A trafficking-deficient KCNQ1 mutation, T587M, causes a severe phenotype of long QT syndrome by interfering with intracellular hERG transport von Wu, Jie, Sakaguchi, Tomoko, Takenaka, Kotoe, Toyoda, Futoshi, Tsuji, Keiko, Matsuura, Hiroshi, Horie, Minoru

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Identification of transmembrane protein 168 mutation in familial Brugada syndrome von Shimizu, Akio, Zankov, Dimitar P., Sato, Akira, Komeno, Masahiro, Toyoda, Futoshi, Yamazaki, Satoru, Makita, Toshinori, Noda, Taichi, Ikawa, Masahito, Asano, Yoshihiro, Miyashita, Yohei, Takashima, Seiji, Morita, Hiroshi, Ishikawa, Taisuke, Makita, Naomasa, Hitosugi, Masahito, Matsuura, Hiroshi, Ohno, Seiko, Horie, Minoru, Ogita, Hisakazu

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The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation von Mesirca, Pietro, Marger, Laurine, Toyoda, Futoshi, Rizzetto, Riccardo, Audoubert, Matthieu, Dubel, Stefan, Torrente, Angelo G, Difrancesco, Mattia L, Muller, Jana Christina, Leoni, Anne-Laure, Couette, Brigitte, Nargeot, Joël, Clapham, David E, Wickman, Kevin, Mangoni, Matteo E

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P2X7 ionotropic receptor is functionally expressed in rabbit articular chondrocytes and mediates extracellular ATP cytotoxicity von Tanigawa, Hitoshi, Toyoda, Futoshi, Kumagai, Kosuke, Okumura, Noriaki, Maeda, Tsutomu, Matsuura, Hiroshi, Imai, Shinji

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Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells von Himeno, Yukiko, Toyoda, Futoshi, Satoh, Hiroyasu, Amano, Akira, Cha, Chae Young, Matsuura, Hiroshi, Noma, Akinori

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Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment von Ding, Wei-Guang, Xie, Yu, Toyoda, Futoshi, Matsuura, Hiroshi

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Propofol, an Anesthetic Agent, Inhibits HCN Channels through the Allosteric Modulation of the cAMP-Dependent Gating Mechanism von Shimizu, Morihiro, Mi, Xinya, Toyoda, Futoshi, Kojima, Akiko, Ding, Wei-Guang, Fukushima, Yutaka, Omatsu-Kanbe, Mariko, Kitagawa, Hirotoshi, Matsuura, Hiroshi

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17β‐Oestradiol inhibits doxorubicin‐induced apoptosis via block of the volume‐sensitive Cl‐ current in rabbit articular chondrocytes von Kumagai, Kousuke, Imai, Shinji, Toyoda, Futoshi, Okumura, Noriaki, Isoya, Eiji, Matsuura, Hiroshi, Matsusue, Yoshitaka

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Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation von Kubo, Taeko, Ding, Wei-Guang, Toyoda, Futoshi, Fujii, Yusuke, Omatsu-Kanbe, Mariko, Matsuura, Hiroshi

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A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels von Hasegawa, Kanae, MD, Ohno, Seiko, MD, PhD, Ashihara, Takashi, MD, PhD, Itoh, Hideki, MD, PhD, Ding, Wei-Guang, PhD, Toyoda, Futoshi, PhD, Makiyama, Takeru, MD, PhD, Aoki, Hisaaki, MD, PhD, Nakamura, Yoshihide, MD, PhD, Delisle, Brian P., PhD, Matsuura, Hiroshi, MD, PhD, Horie, Minoru, MD, PhD

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