Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries von Misek, Sean A., Fultineer, Aaron, Kalfon, Jeremie, Noorbakhsh, Javad, Boyle, Isabella, Roy, Priyanka, Dempster, Joshua, Petronio, Lia, Huang, Katherine, Saadat, Alham, Green, Thomas, Brown, Adam, Doench, John G., Root, David E., McFarland, James M., Beroukhim, Rameen, Boehm, Jesse S.

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LGG-59. Identifying hidden drivers of low-grade glioma tumor growth von Misek, Sean, Fultineer, Aaron, Condurat, Alexandra, Zhou, Kevin, Root, David, Persky, Nicole, Boehm, Jesse, Bandopadhayay, Pratiti, Beroukhim, Rameen

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LGG-29. BEYOND MAPK SIGNALING - GENOME-SCALE CRISPR/CAS9 SCREENS REVEAL NEW TARGETS FOR TREATMENT OF KIAA1549::BRAF-DRIVEN PEDIATRIC LOW-GRADE GLIOMA von Borgenvik, Anna, Misek, Sean, Zhang, Alexander, Fekade, Ruth, Ragnoni, Timothy, Fultineer, Aaron, Zhou, Kevin, Bondeson, Daniel, Novikov, Dana, Bahadur, Sher, Choi, Seung (Riley) H, Goodale, Amy, Condurat, Alexandra L, Cordero, Carolina Ortiz, Persky, Nicole, Kiessling, Laura, Root, David, Eck, Michael, Boehm, Jesse, Jones, David, Beroukhim, Rameen, Bandopadahayay, Pratiti (Mimi)

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LGG-26. A ROLE FOR BRAF FUSION PARTNERS IN ONCOGENIC SIGNALING von Misek, Sean, Borgenvik, Anna, Fekade, Ruth, Zhang, Alexander, Ragnoni, Timothy, Fultineer, Aaron, Zhou, Kevin, Bondeson, Daniel, Novikov, Dana, Bahadur, Sher, Choi, Seung Hyun, Goodale, Amy, Condurat, Alexandra-Larisa, Cordero, Carolina, Persky, Nicole, Kiessling, Laura, Root, David, Eck, Michael, Boehm, Jesse, Jones, David, Beroukhim, Rameen, Bandopadhayay, Pratiti

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Abstract 2173: Ancestry bias in CRISPR guide design impedes discovery of genetic dependencies von Misek, Sean Alexander, Fultineer, Aaron, Kalfon, Jeremie, Noorbakhsh, Javad, Boyle, Isabella, Dempster, Joshua, Petronio, Lia, Huang, Katherine, McFarland, James, Beroukhim, Rameen, Boehm, Jesse

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