Adult T‐cell leukemia‐lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism von Yoshida‐Sakai, Nao, Watanabe, Tatsuro, Yamamoto, Yuta, Ureshino, Hiroshi, Kamachi, Kazuharu, Kurahashi, Yuki, Fukuda‐Kurahashi, Yuki, Kimura, Shinya

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P476: AN ORAL COMBINATION THERAPY OF OR‐2100 AND VENETOCLAX IN ACUTE MYELOID LEUKEMIA von Kamachi, Kazuharu, Ureshino, Hiroshi, Kawasoe, Kazunori, Kidoguchi, Keisuke, Yamamoto, Yuta, Fukuda‐Kurahashi, Yuki, Kurahashi, Yuki, Watanabe, Tatsuro, Kimura, Shinya

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P1236: REGULATION OF DNA AND HISTONE METHYLATION THROUGH METHIONINE METABOLISM IN ATL LEUKEMOGENESIS von Watanabe, Tatsuro, Kitamura, Sho, Kai, Keita, Yamashita, Satoshi, Hattori, Naoko, Yamamoto, Yuta, Kamachi, Kazuharu, Kurahashi, Yuki, Ureshino, Hiroshi, Fukuda‐Kurahashi, Yuki, Nakamura, Hideaki, Sato, Akemi, Okada, Seiji, Ushijima, Toshikazu, Sueoka, Eisaburo, Kimura, Shinya

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Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100 von Watanabe, Tatsuro, Yamashita, Satoshi, Ureshino, Hiroshi, Kamachi, Kazuharu, Kurahashi, Yuki, Fukuda-Kurahashi, Yuki, Yoshida, Nao, Hattori, Naoko, Nakamura, Hideaki, Sato, Akemi, Kawaguchi, Atsushi, Sueoka-Aragane, Naoko, Kojima, Kensuke, Okada, Seiji, Ushijima, Toshikazu, Kimura, Shinya, Sueoka, Eisaburo

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Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL von Kurahashi, Yuki, Watanabe, Tatsuro, Yamamoto, Yuta, Ureshino, Hiroshi, Kamachi, Kazuharu, Yoshida-Sakai, Nao, Fukuda-Kurahashi, Yuki, Yamashita, Satoshi, Hattori, Naoko, Nakamura, Hideaki, Kawaguchi, Atsushi, Ushijima, Toshikazu, Sueoka, Eisaburo, Kimura, Shinya

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Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia von Kamachi, Kazuharu, Ureshino, Hiroshi, Watanabe, Tatsuro, Yoshida-Sakai, Nao, Fukuda-Kurahashi, Yuki, Kawasoe, Kazunori, Hoshiko, Toshimi, Yamamoto, Yuta, Kurahashi, Yuki, Kimura, Shinya

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DNA demethylating agents for chemoprevention of oncovirus-associated leukemogenesis von Yamamoto, Yuta, Watanabe, Tatsuro, Ureshino, Hiroshi, Kurahashi, Yuki, Fukuda-Kurahashi, Yuki, Kamachi, Kazuharu, Kawasoe, Kazunori, Kidoguchi, Keisuke, Yamashita, Satoshi, Hattori, Naoko, Ushijima, Toshikazu, Kimura, Shinya

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Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects von Ureshino, Hiroshi, Kurahashi, Yuki, Watanabe, Tatsuro, Yamashita, Satoshi, Kamachi, Kazuharu, Yamamoto, Yuta, Fukuda-Kurahashi, Yuki, Yoshida-Sakai, Nao, Hattori, Naoko, Hayashi, Yoshihiro, Kawaguchi, Atsushi, Tohyama, Kaoru, Okada, Seiji, Harada, Hironori, Ushijima, Toshikazu, Kimura, Shinya

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Aberrant Regional DNA Hypermethylation As a Preventive and Therapeutic Target for Adult T-Cell Leukemia-Lymphoma von Watanabe, Tatsuro, Ureshino, Hiroshi, Kurahashi, Yuki, Fukuda-Kurahashi, Yuki, Yamashita, Satoshi, Ushijima, Toshikazu, Okada, Seiji, Sueoka, Eisaburo, Kimura, Shinya

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A Combination of Alectinib and DNA-Demethylating Agents Synergistically Inhibits Anaplastic-Lymphoma-Kinase-Positive Anaplastic Large-Cell Lymphoma Cell Proliferation von Kawasoe, Kazunori, Watanabe, Tatsuro, Yoshida-Sakai, Nao, Yamamoto, Yuta, Kurahashi, Yuki, Kidoguchi, Keisuke, Ureshino, Hiroshi, Kamachi, Kazuharu, Fukuda-Kurahashi, Yuki, Kimura, Shinya

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Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells von Watanabe, Tatsuro, Yamamoto, Yuta, Kurahashi, Yuki, Kawasoe, Kazunori, Kidoguchi, Keisuke, Ureshino, Hiroshi, Kamachi, Kazuharu, Yoshida-Sakai, Nao, Fukuda-Kurahashi, Yuki, Nakamura, Hideaki, Okada, Seiji, Sueoka, Eisaburo, Kimura, Shinya

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OR21, a New Oral DNA Methyltransferase Inhibitor for Treatment of MDS and AML von Ureshino, Hiroshi, Watanabe, Tatsuro, Kurahashi, Yuki, Kurahashi, Yuki Fukuda, Tohyama, Kaoru, Okada, Seiji, Ushijima, Toshikazu, Ureshino, Hiroshi

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Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia von Kamachi, Kazuharu, Ureshino, Hiroshi, Watanabe, Tatsuro, Yoshida, Nao, Yamamoto, Yuta, Kurahashi, Yuki, Fukuda-Kurahashi, Yuki, Hayashi, Yoshihiro, Hirai, Hideyo, Yamashita, Satoshi, Ushijima, Toshikazu, Okada, Seiji, Kimura, Shinya

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