Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action von Steinman, Jonathan B, Santarossa, Cristina C, Miller, Rand M, Yu, Lola S, Serpinskaya, Anna S, Furukawa, Hideki, Morimoto, Sachie, Tanaka, Yuta, Nishitani, Mitsuyoshi, Asano, Moriteru, Zalyte, Ruta, Ondrus, Alison E, Johnson, Alex G, Ye, Fan, Nachury, Maxence V, Fukase, Yoshiyuki, Aso, Kazuyoshi, Foley, Michael A, Gelfand, Vladimir I, Chen, James K, Carter, Andrew P, Kapoor, Tarun M

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Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor von Imaeda, Yasuhiro, Tokuhara, Hidekazu, Fukase, Yoshiyuki, Kanagawa, Ray, Kajimoto, Yumiko, Kusumoto, Keiji, Kondo, Mitsuyo, Snell, Gyorgy, Behnke, Craig A, Kuroita, Takanobu

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Synthesis of Rubrivivax gelatinosus Lipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory Activities von Fukase, Yoshiyuki, Fujimoto, Yukari, Adachi, Yo, Suda, Yasuo, Kusumoto, Shoichi, Fukase, Koichi

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NMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assembly von Oikawa, Masato, Shintaku, Tetsuya, Fukuda, Naohiro, Sekljic, Harald, Fukase, Yoshiyuki, Yoshizaki, Hiroaki, Fukase, Koichi, Kusumoto, Shoichi

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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)­cyclobutyl]­acetic Acid (TAK-828... von Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Nara, Yoshi, Fukase, Yoshiyuki, Yukawa, Tomoya, Tokuhara, Hidekazu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac D, Snell, Gyorgy P, Uga, Keiko, Shibata, Akira, Igaki, Keiko, Nakamura, Yoshiki, Nakagawa, Hideyuki, Tsuchimori, Noboru, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

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Targeting allostery in the Dynein motor domain with small molecule inhibitors von Santarossa, Cristina C., Mickolajczyk, Keith J., Steinman, Jonathan B., Urnavicius, Linas, Chen, Nan, Hirata, Yasuhiro, Fukase, Yoshiyuki, Coudray, Nicolas, Ekiert, Damian C., Bhabha, Gira, Kapoor, Tarun M.

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Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules von Singh, Kamini, Lin, Jianan, Lecomte, Nicolas, Mohan, Prathibha, Gokce, Askan, Sanghvi, Viraj R, Jiang, Man, Grbovic-Huezo, Olivera, Burčul, Antonija, Stark, Stefan G, Romesser, Paul B, Chang, Qing, Melchor, Jerry P, Beyer, Rachel K, Duggan, Mark, Fukase, Yoshiyuki, Yang, Guangli, Ouerfelli, Ouathek, Viale, Agnes, de Stanchina, Elisa, Stamford, Andrew W, Meinke, Peter T, Rätsch, Gunnar, Leach, Steven D, Ouyang, Zhengqing, Wendel, Hans-Guido

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Identification of novel quinazolinedione derivatives as RORγt inverse agonist von Fukase, Yoshiyuki, Sato, Ayumu, Tomata, Yoshihide, Ochida, Atsuko, Kono, Mitsunori, Yonemori, Kazuko, Koga, Keiko, Okui, Toshitake, Yamasaki, Masashi, Fujitani, Yasushi, Nakagawa, Hideyuki, Koyama, Ryoukichi, Nakayama, Masaharu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac, Shirai, Junya, Yamamoto, Satoshi

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Targeting allostery in the Dynein motor domain with small molecule inhibitors von Santarossa, Cristina C., Mickolajczyk, Keith J., Steinman, Jonathan B., Urnavicius, Linas, Chen, Nan, Hirata, Yasuhiro, Fukase, Yoshiyuki, Coudray, Nicolas, Ekiert, Damian C., Bhabha, Gira, Kapoor, Tarun M.

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Deglycase-activity oriented screening to identify DJ-1 inhibitors von Maksimovic, Igor, Finkin-Groner, Efrat, Fukase, Yoshiyuki, Zheng, Qingfei, Sun, Shan, Michino, Mayako, Huggins, David J, Myers, Robert W, David, Yael

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Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives von Kono, Mitsunori, Oda, Tsuneo, Tawada, Michiko, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Kawamoto, Tetsuji, Tokuhara, Hidekazu, Tomata, Yoshihide, Ishii, Naoki, Ochida, Atsuko, Fukase, Yoshiyuki, Yukawa, Tomoya, Fukumoto, Shoji, Watanabe, Hiroyuki, Uga, Keiko, Shibata, Akira, Nakagawa, Hideyuki, Shirasaki, Mikio, Fujitani, Yasushi, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

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Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds von Shirai, Junya, Tomata, Yoshihide, Kono, Mitsunori, Ochida, Atsuko, Fukase, Yoshiyuki, Sato, Ayumu, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Koyama, Ryoukichi, Nakagawa, Hideyuki, Nakayama, Masaharu, Uga, Keiko, Shibata, Akira, Koga, Keiko, Okui, Toshitake, Shirasaki, Mikio, Skene, Robert, Sang, BiChing, Hoffman, Isaac, Lane, Wes, Fujitani, Yasushi, Yamasaki, Masashi, Yamamoto, Satoshi

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Synthesis Based on Affinity Separation (SAS): Separation of Products Having Barbituric Acid Tag from Untagged Compounds by Using Hydrogen Bond Interaction von Zhang, San-Qi, Fukase, Koichi, Izumi, Minoru, Fukase, Yoshiyuki, Kusumoto, Shoichi

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Synthesis and Biological Activities of Lipid A Analogs Possessing β-Glycosidic Linkage at 1-Position von Fukase, Koichi, Ueno, Atsushi, Fukase, Yoshiyuki, Oikawa, Masato, Suda, Yasuo, Kusumoto, Shoichi

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Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile von Tokuhara, Hidekazu, Imaeda, Yasuhiro, Fukase, Yoshiyuki, Iwanaga, Koichi, Taya, Naohiro, Watanabe, Koji, Kanagawa, Ray, Matsuda, Keisuke, Kajimoto, Yumiko, Kusumoto, Keiji, Kondo, Mitsuyo, Snell, Gyorgy, Behnke, Craig A., Kuroita, Takanobu

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Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055 von Michino, Mayako, Khan, Tanweer A., Miller, Michael W., Fukase, Yoshiyuki, Vendome, Jeremie, Adura, Carolina, Glickman, J. Fraser, Liu, Yiman, Wan, Liling, Allis, C. David, Stamford, Andrew W., Meinke, Peter T., Renzetti, Louis M., Kargman, Stacia, Liverton, Nigel J., Huggins, David J.

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Synthesis of [3H]-Labeled Bioactive Lipid A Analogs and Their Use for Detection of Lipid A-Binding Proteins on Murine Macrophages von Fukase, Koichi, Kirikae, Teruo, Kirikae, Fumiko, Liu, Wen-Chi, Oikawa, Masato, Suda, Yasuo, Kurosawa, Motohiro, Fukase, Yoshiyuki, Yoshizaki, Hiroaki, Kusumoto, Shoichi

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Development of a Pure Small Molecule αVβ3 Antagonist von Li, Jihong, Fukase, Yoshiyuki, Shang, Yi, Zou, Wei, Hara, Ryoma, Tanaka, Yuta, Okamoto, Rei, Yasui, Takeshi, Nakahata, Takashi, Imaeda, Toshihiro, Aso, Kazuyoshi, Locuson, Charles, Nesic, Dragana, Duggan, Mark, Teitelbaum, Steven, Filizola, Marta, Foley, Michael, Coller, Barry S.

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New Efficient Route for Synthesis of Lipid A by using Affinity Separation von Fukase, Yoshiyuki, Zhang, San-Qi, Iseki, Keiko, Oikawa, Masato, Fukase, Koichi, Kusumoto, Shoichi

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Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists von Sato, Ayumu, Fukase, Yoshiyuki, Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Sasaki, Yusuke, Ishii, Naoki, Tomata, Yoshihide, Fukumoto, Shoji, Imai, Yumi N., Uga, Keiko, Shibata, Akira, Yamasaki, Masashi, Nakagawa, Hideyuki, Shirasaki, Mikio, Skene, Robert, Hoffman, Isaac, Sang, Bi‐Ching, Snell, Gyorgy, Shirai, Junya, Yamamoto, Satoshi

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