Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival von Lu, Xi, Maturi, Naga Prathyusha, Jarvius, Malin, Yildirim, Irem, Dang, Yonglong, Zhao, Linxuan, Xie, Yuan, Tan, E-Jean, Xing, Pengwei, Larsson, Rolf, Fryknäs, Mårten, Uhrbom, Lene, Chen, Xingqi

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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models von Selvin, Tove, Berglund, Malin, Åkerström, Anders, Zia, Marco, Rudfeldt, Jakob, Jarvius, Malin, Larsson, Rolf, Andersson, Claes R, Fryknäs, Mårten

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Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide von Byrgazov, Konstantin, Anderson, Claes, Salzer, Benjamin, Bozsaky, Eva, Larsson, Rolf, Gullbo, Joachim, Lehner, Manfred, Lehmann, Fredrik, Slipicevic, Ana, Kager, Leo, Fryknäs, Mårten, Taschner-Mandl, Sabine

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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer von Mansoori, S., Fryknäs, M., Alvfors, C., Loskog, A., Larsson, R., Nygren, P.

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Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system von Karlsson, Henning, Fryknäs, Mårten, Larsson, Rolf, Nygren, Peter

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Inhibition of proteasome deubiquitinating activity as a new cancer therapy von D'Arcy, Pádraig, Brnjic, Slavica, Olofsson, Maria Hägg, Fryknäs, Mårten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig

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Effect of liver stiffness on hepatocellular carcinoma phenotype in a biometric 3D model von Calitz, Carlemi, Khaled, Jaafar, Rosenquist, Jenny, Kopsida, Maria, Degerstedt, Oliver, Lennernas, Hans, Fryknäs, Mårten, Samanta, Ayan, Heindryckx, Femke

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Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model von Selvin, Tove, Fasterius, Erik, Jarvius, Malin, Fryknäs, Mårten, Larsson, Rolf, Andersson, Claes R.

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Effects of hypoxia on human cancer cell line chemosensitivity von Strese, Sara, Fryknäs, Mårten, Larsson, Rolf, Gullbo, Joachim

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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma von Calitz, Carlemi, Rosenquist, Jenny, Degerstedt, Oliver, Khaled, Jaafar, Kopsida, Maria, Fryknäs, Mårten, Lennernäs, Hans, Samanta, Ayan, Heindryckx, Femke

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Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition von Segerman, Anna, Niklasson, Mia, Haglund, Caroline, Bergström, Tobias, Jarvius, Malin, Xie, Yuan, Westermark, Ann, Sönmez, Demet, Hermansson, Annika, Kastemar, Marianne, Naimaie-Ali, Zeinab, Nyberg, Frida, Berglund, Malin, Sundström, Magnus, Hesselager, Göran, Uhrbom, Lene, Gustafsson, Mats, Larsson, Rolf, Fryknäs, Mårten, Segerman, Bo, Westermark, Bengt

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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer von Senkowski, Wojciech, Zhang, Xiaonan, Olofsson, Maria Hägg, Isacson, Ruben, Höglund, Urban, Gustafsson, Mats, Nygren, Peter, Linder, Stig, Larsson, Rolf, Fryknäs, Mårten

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Improved variance estimation of classification performance via reduction of bias caused by small sample size von Wickenberg-Bolin, Ulrika, Göransson, Hanna, Fryknäs, Mårten, Gustafsson, Mats G, Isaksson, Anders

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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death von Selvin, Tove, Berglund, Malin, Lenhammar, Lena, Jarvius, Malin, Nygren, Peter, Fryknäs, Mårten, Larsson, Rolf, Andersson, Claes R

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MODL-23. PAIRED GLIOBLASTOMA CELL CULTURES OF THE FLUORESCENT BULK TUMOR AND NON-FLUORESCENT TUMOR MARGIN DISPLAY DIFFERENTIAL PHENOTYPES AND CELL STATES ACROSS PATIENTS von Neves, Inês, Maturi, Nagaprathyusha, Dang, Yonglong, Lu, Xi, Latini, Francesco, Yildirim, Irem, Sundström, Anders, Jokinen, Veera, Bergström, Tobias, Xing, Pengwei, Jarvius, Malin, Larsson, Rolf, Fryknäs, Mårten, Ryttlefors, Mats, Chen, Xingqi, Swartling, Fredrik, Uhrbom, Lene

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Anti-Myeloma Drug Melflufen Inhibits RANKL-Stimulated Osteoclastogenesis By Suppressing Proliferation of CD14+ Precursor Cells von Byrgazov, Konstantin, Rasmusson, Annica, Andersson, Claes, Berglund, Malin, Lenhammar, Lena, Melhus, Håkan, Gullbo, Joachim, Slipicevic, Ana, Lehmann, Fredrik, Larsson, Rolf, Lind, Thomas, Fryknäs, Mårten

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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids von Mickols, Evgeniya, Meyer, Alina, Handin, Niklas, Stüwe, Malin, Eriksson, Jens, Rudfeldt, Jakob, Blom, Kristin, Fryknäs, Mårten, Sellin, Mikael E., Lauschke, Volker M., Karlgren, Maria, Artursson, Per

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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma von Ek, Frida, Blom, Kristin, Selvin, Tove, Rudfeldt, Jakob, Andersson, Claes, Senkowski, Wojciech, Brechot, Christian, Nygren, Peter, Larsson, Rolf, Jarvius, Malin, Fryknäs, Mårten

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Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer von Nygren, Peter, Fryknäs, Mårten, Ågerup, Bengt, Larsson, Rolf

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STEM-08. MODELING AND UNDERSTANDING GLIOBLASTOMA EDGE CELLS von Maturi, Naga Prathyusha, Neves, Ines, Dang, Yonglong, Yildirim, Irem, Latini, Francesco, Bergström, Tobias, Sundström, Anders, Xing, Pengwei, Jarvius, Malin, Larsson, Rolf, Fryknäs, Mårten, Ryttlefors, Mats, Chen, Xingqi, Swartling, Fredrik, Uhrbom, Lene

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